NAME：Hang Ruan

Dr. Hang Ruan obtained a Bachelor's degree in Biology and a Master's degree in Ecology from Nanjing University during 2004-2011. From 2011 to 2014, he worked as a Bioinformatics R&D Engineer at Beijing Novogene Co, Ltd., receiving systematic training in computational science. After that, he pursued a Ph.D. in Bioinformatics (comparative transcriptome) at Fudan University under the supervision of Chinese geneticist Xun Gu from 2014 to 2017.

In the period 2017-2020, Dr. Ruan conducted postdoctoral research (focusing on cancer multi-omics data analysis) at the University of Texas Health Science Center at Houston, collaborating with Professor Leng Han. In December 2020, he joined the Institutes of Biology and Medical Sciences (IBMS) at Soochow University as a professor.

Dr. Ruan has been engaged in interdisciplinary research of bioinformatics in both industry and academia. His current research focuses on utilizing genetic statistical methods and artificial intelligence for multi-omics big data analysis, particularly in immune-related complex diseases. His work contributes valuable data for understanding the genetic basis, molecular mechanisms, and diagnostic and therapeutic aspects of relevant diseases. Dr. Ruan has authored over twenty papers, accumulating more than 1800 citations.

Recent publications (Refer toGoogle Scholarfor full publication list) :

Ruan, H.*, Wang, PC., & Han, L.* (2022).Characterization of circular RNAs with advanced sequencing technologies in human complex diseases.Wiley Interdisciplinary Reviews: RNA, 14(1), e1759.(IF = 9.35)

Ruan, H.*, Li, Q., Liu, Y., Liu, Y., Lussier, C., ... & Han, L.* (2021). GPEdit: the genetic and pharmacogenomic landscape of A-to-I RNA Editing in cancers.Nucleic acids research,50(D1), D1231-D1237. (IF = 16.974)

Hong, W.#, Ruan, H.#, Zhang, Z., Ye, Y., Liu, Y., Li, S., ... & Han, L.* (2020). APAatlas: decoding alternative polyadenylation across human tissues.Nucleic acids research, 48(D1), D34-D39.(IF = 16.974)

Ruan, H.#, Liao, Y.#, Ren, Z., Mao, L., Yao, F., Yu, P., ... & Wang, L.* (2019). Single-cell reconstruction of differentiation trajectory reveals a critical role of ETS1 in human cardiac lineage commitment.BMC biology, 17(1), 1-16.(IF = 7.432)

Ruan, H.#, Xiang, Y.#, Ko, J.#, Li, S.#, Jing, Y., Zhu, X., ... & Han, L*. (2019). Comprehensive characterization of circular RNAs in~ 1000 human cancer cell lines.Genome medicine, 11(1), 1-14.(IF = 11.113)

Gu, X.*, Ruan, H., & Yang, J. (2019). Estimating the strength of expression conservation from high throughput RNA-seq data.Bioinformatics, 35(23), 5030-5038.(IF = 6.932)

Yang, J.#, Ruan, H.#, Xu, W., & Gu, X*. (2019). TreeExp2: An Integrated Framework for Phylogenetic Transcriptome Analysis.Genome biology and evolution, 11(11), 3276-3282.(IF = 3.412)

Zhang, Z.#, Lee, J. H.#, Ruan, H.#, Ye, Y., Krakowiak, J., Hu, Q., ... & Han, L*. (2019). Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer.Nature communications, 10(1), 1-12.(IF = 14.914)

Ye, Y., Hu, Q., Chen, H., Liang, K., Yuan, Y., Xiang, Y., ... & Han, L. (2019). Characterization of hypoxia-associated molecular features to aid hypoxia-targeted therapy.Nature metabolism, 1(4), 431-444.(IF = 13.510)

Ruan, H., & Han, L*. (2018). Regulatory RNA Editing Sites in Cancer: Prediction and Beyond.EBioMedicine, 27, 7-8.(IF = 8.143)

Books Patents