包鹏辉教授

包鹏辉，理学博士，www.优德88.cpm基础医学与生物科学学院分子酶学研究所特聘教授、博士生导师。2002年毕业于武汉大学生物技术专业。2009年获得武汉大学理学博士学位。研究兴趣：RNA功能生物学。在生物学的中心法则中，RNA处于传递信息、调控信息的关键位置，内含子RNA的剪接揭示了生物多样性的基因机制，剪接体在真核生物中执行RNA剪接，调控基因表达。RNA分子自身具有多种多样的生物学功能。

1、Bao P,Boon KL, Will CL, Hartmuth K, Luehrmann R. (2018) Multiple RNA-RNA tertiary interactions are dispensable for formation of a functional U2/U6 RNA catalytic core in the spliceosome.Nucleic Acids Research46: 12126-12138.

2、Bao P, Will CL, Urlaub H, Boon KL, Luehrmann R. (2017) The RES complex is required for efficient transformation of the precatalytic B spliceosome into an activated B^actcomplex.Genes & Development. 31(23-24):2416-2429.

3、Bao P, Wu Q-J, Yin P, Jiang Y-F, Wang X, Xie MH, Sun T, Huang L, Mo D, Zhang Y. (2008). Coordination of two sequential ester-transfer reactions: Exogenous guanosine binding promotes the subsequent omegaG binding to a group I intron.Nucleic Acids Research36: 6934-6943.

4、Bao P, Hoebartner C, Hartmuth K, Luehrmann R. (2017) Yeast Prp2 liberates the 5' splice site and the branch site adenosine for catalysis of pre-mRNA splicing.RNA.23(12): 1770-1779.

5、Sidarovich A, Will CL, Anokhina MM, Ceballos J, Sievers S, Agafonov DE, Samatov T,Bao P, Kastner B, Urlaub H, Waldmann H, Luehrmann R. (2017) Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation.Elife. 6. pii: e23533.

6、Wu J, Zhou J, Qu F,Bao P, Zhang Y, Peng L. (2005) Polycationic dendrimers interact with RNA molecules: polyamine dendrimers inhibit the catalytic activity ofCandidaribozymes.Chemical Communications (Camb). 3:313-315.

7、Zhang L,Bao P, Leibowitz MJ, Zhang Y. (2009) Slow formation of a pseudoknot structure is rate limiting in the productive co-transcriptional folding of the self-splicingCandidaintron.RNA. 15:1986-1992.

8、Mo D, Wu L, Xu Y, Ren J, Wang L, Huang L, Wu Q-J,Bao P, Xie MH, Yin P, Liu BF, Liang Y, Zhang Y. (2011) A maturase that specifically stabilizes and activates its cognate group I intron at high temperatures.Biochimie. 93: 533-541.

9、Xie MH, Wu Q-J, Jiang Y-F,Bao P, Zhang Y. (2009)A phage RNA-binding protein binds to a non-cognate structured RNA and stabilizes its core structure.Biochememical Biophysical Research Communication. 378:168-173.

1.RNA分子生物学

2.RNA与蛋白质相互作用

3.生物大分子与RNA剪接