王晓沁

发布日期：2018-04-20

个人简介

理学博士。1969年1月生。www.优德88.cpm 特聘教授，苏州丝美特生物技术有限公司创始人兼首席科学家，美国Tufts大学生物医学系助理教授，苏州工业园区纳米领军人才、姑苏领军人才。现任职www.优德88.cpm 纺织与服装工程学院及现代丝绸国家工程实验室，创建了www.优德88.cpm-Tufts大学生物医用材料联合实验室。主要研究天然丝素蛋白生物材料的工业化制备及其在组织工程修复、药物递送、生物3D打印、生物传感器和日用品工业中的应用。正在主持国家自然科学基金中德科技合作项目、国家自然科学基金面上项目和工业横向项目。王晓沁于1991年获得山东大学微生物工程专业学士学位，1998年获得北京协和医科大学分子生物学硕士学位，2004年获得荷兰格罗宁根（Groningen）大学博士学位。曾先后任职荷兰贝尔美德（BioMaDe）生物技术公司、美国塔夫茨（Tufts）大学生物医学系、美国ETEX生物技术公司、美国Ekteino Laboratory, Cocoon Biotech等生物技术公司，担任新产品和新技术研发负责人。

研究方向及主讲课程

主要研究方向：丝素蛋白基药物缓释及组织修复；功能化丝素蛋白生物材料

近五年主持的科研项目

1.国家重点研发计划“生物医用材料研发及组织器官修复替代” （项目参与） 2017-2021

2.国家自然科学基金中德合作项目：有效利用巨噬细胞可塑性促进骨再生（项目主持）2015年至今

3.国家自然科学基金面上项目: 抗氧化剂修饰的丝素蛋白生物材料对细胞生长和功能的调控（项目主持）2012017年

4.姑苏领军创业人才项目：丝素蛋白止血防粘连材料的开发和应用（项目主持）2013-2017年

近五年发表的代表性论文和教材

2014-2017发表论文：

1. Wu J, Xie X, Zheng Z, Li G, Wang Y, Wang X*. Effect of pH on polyethylene glycol (PEG)-induced silk microsphere formation for drug delivery. Materials Science and Engineering: C Materials for Biological Applications. 2017 Nov 1;80:549-557.

2. Liu Y, Zheng Z, Guo S, Li G, Wang X*, Kaplan DL. DNA preservation in silk. Biomaterials Science. 2017 Jun 27;5(7):1279-1292.

3. Yang L, Zheng Z, Qian C, Wu J, Liu Y, Guo S, Li G, Liu M, Wang X, Kaplan DL. Curcumin-functionalized silk biomaterials for anti-aging utility. J Colloid Interface Sci. 2017;496:66-77 (SCI, IF: 3.368)

4. Luo T, Yang L, Wu J, Zheng Z, Li G, Wang X^*, Kaplan DL. Stabilization of Natural Antioxidants by Silk Biomaterials. ACS Appl Mater Interfaces. 2016;8:13573-13582. doi: 10.1021/acsami.6b01636. Epub 2016 May 17. PMID: 27139741 (SCI, IF: 7.145; Field-Weighted Citation Impact: 0.83; cited number: 2)

5. Wu J, Zheng Z, Li G, Kaplan DL, Wang X^*. Control of silk microsphere formation using polyethylene glycol (PEG). Acta Biomaterialia. 2016;39:156-168. doi: 10.1016/j.actbio.2016.05.019. Epub 2016 May 12. PMID: 27181879 (SCI, IF: 6.025; Field-Weighted Citation Impact: 1.98; cited number: 3)

6. Zheng Z, Guo S, Liu Y, Wu J, Li G, Liu M, Wang X^*, Kaplan D. Lithium-free processing of silk fibroin. J Biomater Appl. 2016;31:450-463. doi: 10.1177/0885328216653259. Epub 2016 Jun 12. PMID: 27298185 (SCI, IF: 2.764; Field-Weighted Citation Impact: 0; cited number: 0)

7. Yu D，Sun C, Zheng Z, Wang X, Chen D, Wu H, Wang X^*, Shi F. Inner ear delivery of dexamethasone using injectable silk-polyethylene glycol (PEG) hydrogel. Int J Pharm. 2016;503:229-237. doi: 10.1016/j.ijpharm.2016.02.048. Epub 2016 Mar 10. PMID: 26972377 (SCI, IF: 3.65; Field-Weighted Citation Impact: 5.03; cited number: 3)

8. Li G, Li F, Zheng Z, Luo T, Liu J, Wu J, Wang X^*, Kaplan DL. Silk microfiber-reinforced silk composite scaffolds: fabrication, mechanical properties, and cytocompatibility. J Mater Sci. 2016;51:3025-3035 (SCI, IF: 2.302; Field-Weighted Citation Impact: 2.17; cited number: 2)

9. Wang Y, Liang M, Zheng Z, Shi L, Su B, Liu J, Kaplan DL, Zhang B, Wang X^*. Adhesion Prevention after Laminectomy using Silk-polyethylene glycol (PEG) Hydrogels. Adv Healthc Mater. 2015;4:2120-2127 Aug 24. doi: 10.1002/adhm.201500392. [Epub ahead of print] PMID: 26386268 (SCI, IF: 5.76; Field-Weighted Citation Impact: 0.33; cited number: 1)

10. Lu D, Zheng Z, Guo S, Wang C, Kaplan DL, Wang X^*. Binding quantum dots to silk biomaterials for optical sensing. J Sensors. 2015:819373 (SCI, IF: 0.712; Field-Weighted Citation Impact: 0.45; cited number: 1)

11. Zheng Z, Liu M, Guo S, Wu J, Lu D, Li G, Liu S, Wang X^*, Kaplan DL. Incorporation of quantum dots in silk biomaterials for fluorescence imaging. J Mater Chem B Mater Biol Med. 2015;3:6509-6519. PMID: 26257913 PMCID: PMC4527682 (SCI, IF: 4.872; Field-Weighted Citation Impact: …; cited number: 3)

12. Li G, Liu J, Zheng Z, Wang X^*, Kaplan DL. Structural Mimetic Silk Fiber-Reinforced Composite Scaffolds Using Multi-Angle Fibers. Macromol Biosci. 2015;15:1125-1133. doi: 10.1002/mabi.201400502. Epub 2015 Apr 16. PMID: 25879693 (SCI, IF: 3.85; Field-Weighted Citation Impact: 0.54; cited number: 2)

13. Li G, Li Y, Chen G, He J, Han Y, Wang X^*, Kaplan DL. Silk-based biomaterials in biomedical textiles and fiber-based implants. Adv Healthc Mater. 2015;4:1134-1151 doi: 10.1002/adhm.201500002. Epub 2015 Mar 13. PMID: 25772248 PMCID: PMC4456268 (SCI, IF: 5.76; Field-Weighted Citation Impact: 1.3; cited number: 11)

14. Lovett ML, Wang X, Yucel T, York L, Keirstead M, Haggerty L, Kaplan DL. Silk hydrogels for sustained ocular delivery of anti-vascular endothelial growth factor (anti-VEGF) therapeutics. Eur J Pharm Biopharm. 2015;95:271-278 doi: 10.1016/j.ejpb.2014.12.029. Epub 2015 Jan 12. PMID: 25592326 (SCI, IF: 4.245; Field-Weighted Citation Impact: 3.07; cited number: 9)

15. Wang X^*, Partlow B, Liu Jian, Zheng Z, Su Bo, Wang Y, Kaplan D. Injectable silk-polyethylene glycol hydrogels. Acta Biomaterialia. 2015;12:51-61 doi: 10.1016/j.actbio.2014.10.027. Epub 2014 Oct 25. PMID: 25449912 (SCI, IF: 6.025; Field-Weighted Citation Impact: 3.9; cited number: 15)

16. Zhou Shun, Huang Wenwen, Belton David J, Simmons Leo O, Perry Carole C, Wang X, Kaplan DL. Control of bioinspired silicification by genetically engineered fusion proteins: silk - silica binding peptides (SiBPs). Acta Biomaterialia. 2015;15:173-180 doi: 10.1016/j.actbio.2014.10.040. Epub 2014 Nov 4. PMID: 25462851 PMCID: PMC4331239 (SCI, IF: 6.025; Field-Weighted Citation Impact: 1.82; cited number: 7)

17. Li C, Luo T, Zheng Z, Murphy AR, Wang X^*, Kaplan DL. Curcumin-functionalized silk materials for enhancing adipogenic differentiation of bone marrow-derived human mesenchymal stem cells. Acta Biomaterialia. 2015;11:222-232 doi: 10.1016/j.actbio.2014.08.009. Epub 2014 Aug 15. PMID: 25132274 PMCID: PMC4256115 (SCI, IF: 6.025; Field-Weighted Citation Impact: 2.08; cited number: 10)

18. Yin Y, Huang P, Li D, Han Z, Wei G, Zhou C, Wen J, Su B, Wang Y, Wang X^*. Collagen nanofibers facilitated presynaptic maturation in differentiated neurons from spinal cord-derived neural stem cells through MAPK/ERK1/2- Synapsin I signaling pathway. Biomacromolecules. 2014;15:2449-2460 doi: 10.1021/bm500321h. Epub 2014 Jul 1. PMID: 24955924 (SCI, IF: 5.75; Field-Weighted Citation Impact: 1.18; cited number: 8)

19. Leng X, Liu B, Su B, Liang M, Shi L, Li S, Qu S, Fu X, Liu Y, Yao M, Wang Y, Wang X^*, Kaplan DL. In Situ Ultrasound Imaging of Silk Hydrogel Degradation and Neovascularization. J Tissue Eng Regen Med. 2017;11:822-830; Med. doi: 10.1002/term.1981. Accession number: 25850825 doi: 10.1002/term.1981. Epub 2015 Apr 5. PMID: 25850825 (SCI, IF: 2.37; Field-Weighted Citation Impact: 0.74; cited number: 1)

20. Qing Liu, Shufa Zhou, Zeyu Zhao, Zhaozhu ZHENG, Gang Li, Xiaoqin Wang. SF/polyethylene Glycol nano-fibrous membranes loaded with Curcumin, Thermal Science 2017, 21(4), 21-27. (SCI, IF 0.95)

授权发明专利情况

1 一种可注射丝素蛋白原位凝胶的制备方法及其应用 ZL201310203722.2 发明授权 2/3

2 一种大分子量丝素蛋白冻干粉的制备工艺 ZL201410118465.7 发明授权 1/2

3 一种家蚕丝素蛋白溶液制备及鉴定 201510071886.3 发明实审 1/2

4 一种治疗内耳疾病的控释缓释丝素蛋白凝胶制剂 201520089733.1 发明实审 1/2

5一种用于药物控释的丝素-载药纳微米颗粒的制备方法 201510918623.1 发明实审 1/4

6 一种大分子量丝素蛋白冻干粉、制备工艺及其应用 PCT/CN2015/075019 发明实审 1/7

7 一种用聚乙二醇制备丝素纳微米球的方法及其在药物控释中的应用 PCT/CN2015/097464 发明实审 1/3

8 一种三维复合结构肛瘘线及其制备方法 201510468318.7 发明实审 5/5

9 一种具有纬纱张力控制器的的织机梭子 5834673 实用新型授权 5/5

10 一种农药残留检测方法及检测试剂盒 201610538541.9 发明实审 2/3

11一种利用丝素蛋白对DNA保存的方法及试剂盒 2016103882027 发明实审 1/2