武艺教授 博士生导师
1965.03.09出生
电话：0512-65880877-3503
传真：0512-65880929
邮箱：wuy@suda.edu.cn
通讯地址：苏州工业园区仁爱路199号www.优德88.cpm 一期703幢3503室,邮编215123
个人简历：
武艺教授，www.优德88.cpm 特聘教授，唐仲英血液学研究中心PI，博士生导师。1987年毕业于河北医科大学；2002年毕业于日本山梨大学医学部，获生物化学博士学位；2002-2004年于美国新泽西医学院从事博士后研究。自2005年后任美国Temple University血栓研究中心任助理教授和副教授。2009年受聘为www.优德88.cpm 特聘教授，现任唐仲英血液学研究中心PI。长期致力于血栓形成的细胞与分子机制的研究，在二硫键异构酶家族对血栓形成的氧化还原调控网络机制及其生物学功能等方面取得了一批成果。共发表论文60余篇，包括Blood,J Clin Invest,J Exp Med，Circulation,Nature Commun,JCI Insight,Arterioscler Thromb Vasc Biol等。多次在国际重要学术会议作大会报告，其研究受国家自然科学基金面上项目、重大研究计划、科技部(973前期项目)、教育部(高等学校博士学科点专项)和日中医学协会共同研究项目等资助。担任国际血栓与止血学会科学与标准化委员会（ISTH-SSC）共同主席，Thrombosis Journal杂志高级副主编，Cell Communication and Signaling、Thrombosis Research等杂志编委。曾获国家科技进步二等奖、美国NIH新研究者奖、日本加藤纪念生命科学基金会奖、苏州市医学会医学科技奖二等奖等。
主要研究方向:
1.血栓形成的整合机制及抗血栓药物的新靶点的研发。
2.二硫键异构酶家族在内质网蛋白稳态的作用与机制。
科研项目：
1.项目来源:国家自然基金-面上项目；项目名称:纤维蛋白原介导血栓形成的功能性二硫键的调控机制；编号:82170129；立项年度：2022/01-2025/12；经费:55万元；在研；项目负责人。
2.项目来源:国家自然基金-面上项目；项目名称:二硫键异构酶TMX1对血小板和凝血系统的双重负性调控作用与机制；编号:81970128；立项年度：2020/01-2023/12；经费:55万元；在研；项目负责人。
3.项目来源:国家自然基金-面上项目；项目名称:跨膜型二硫键异构酶TMX3调控血栓形成的作用与机制；编号：81770138；立项年度：2018/01-2021/12；经费:58万元；在研；项目负责人。
4.项目来源:国家自然基金-重大研究计划培育项目；项目名称:血浆激肽释放酶-激肽系统对内皮祖细胞的调控在血管稳态失衡中的作用与机制；编号:91539122；立项年度：2016/01-2018/12；经费: 90万元；结题；项目负责人。
5.项目来源:国家自然基金-面上项目；项目名称:二硫键异构酶PDI和ERp57调控动脉血栓形成的特异性生理作用和机制研究；编号：81270592；立项年度：2013/01-2016/12；经费:80万元；结题；项目负责人。
6.项目来源:国家自然基金-面上项目；项目名称:尿激酶受体在吞噬凋亡细胞中的新功能及机制；编号: 30971491；立项年度：2010/01-2012/12；经费: 30万元；结题；项目负责人。
代表性论著:
1.Yaqiong Zhang, Aizhen Yang, Zhenzhen Zhao, Fengwu Chen, Xiaofeng Yan, Yue Han, Depei Wu,Yi Wu. Protein disulfide isomerase is essential for spermatogenesis in mice.JCI Insight, 2024；9(12);e177743.(*corresponding author).
2.Keyu Lv, Shuai Chen, Xulin Xu, Joyce Chiu, Haoqing Wang, Yunyun Han, Xiaodan Yang, Sheryl Bowley , Hao Wang, Zhaoming Tang, Ning Tang, Aizhen Yang, Shuofei Yang, Jinyu Wang, Si Jin, Yi Wu, Alvin Schmaier, Lining Ju, Philip Hogg, Chao Fang. Protein Disulfide Isomerase Cleaves Allosteric Disulfides in Histidine-Rich Glycoprotein to Regulate Thrombosis.Nature Communications. 2024;15(1):3129.
3.Yaofeng Li, Xulin Xu, Haoqing Wang, Yiyao Chen, Yaobing Chen, Joyce Chiu, Li Li, Lei Wang, Jinyu Wang, Zhaoming Tang, Lehao Ren, Hongliang Li, Xuanbin Wang, Si Jin,Yi Wu, Mingdong Huang, Lining Ju, and Chao Fang. Endoplasmic Reticulum Protein 72 Regulates Integrin Mac-1Activity to Influence Neutrophil Recruitment.Arteriosclerosis, Thrombosis and Vascular Biology2024.44(3):e82-98.
4.LiangGao, Chao He, Aizhen Yang, Haibin Zhou, Qingxian Lu, Raymond B. Birge,Yi Wu*. Receptor tyrosine kinases Tyro3, Axl, and Mer differentially contribute to antibody-induced arthritis.Cell Communication and Signaling.2023;21(1):195.(*corresponding author).
5.Yi Wu*. Seaweed fucoidan targeting platelet GPIbα: Hope from the ocean.Journal of Thrombosis and Haemostasis, 2023;21(5):1100-1101.(Commentary)(*corresponding author).
6.Y Wu*, Yi Lu, Jingyu Zhang*. Thrombin generation assay: the present and future.Blood Coagulation & Fibrinolysis. 2023;34(1):1-7(*corresponding author).
7.Junsong Zhou,Yi Wu, Karen Fong, Joe Bennett, LuWang, Rauova, V.M. Hayes, M. Poncz, H. Li, T. Liu, D.W. Essex. The disulfide isomerase ERp46 supports platelet activation and arterial thrombosis.Blood.2022;139(13):2050-2065.
8.Yongxue Zhang, Qi Miao, Sai Shi, Han Hao, Xinmeng Li, Yakun Yang, Hailong An, Wei Zhang, Youzhen Kong, Xu Pang, Nikita Gamper,Yi Wu*, Hailin Zhang*, Xiaona Du*. Protein disulfide isomerase (PDI) modulation of TRPV1 controls heat hyperalgesia in chronic pain.Cell Reports2022;39(1):110625.(*corresponding author).
9.Yuxin Zhang, Fengwu Chen, Aizhen Yang, Xiaoying Wang, Yue Han, Depei Wu,Yi Wu*, Jingyu Zhang*.The disulfide bond Cys2724-Cys2774 in the C-terminal cystine knot domain of von Willebrand factor is critical for its dimerization and secretion.Thrombosis Journal,2021, Nov 27;19(1):94. doi: 10.1186/s12959-021-00348-w,(*corresponding author)
10.Yi Wu.Plasmin taking contact system to inflame liver.Blood2021;138(3):208-209. (Commentary)(*corresponding author).
11.Wu Y*,Essex DW*.Vascular thiol isomerases in thrombosis: The Yin and Yang.Journal of Thrombosis andHaemostasis.2020;18(11):2780-2800.(*corresponding author, invited review)
12.Xu Y, Jiang H, Li L, Chen F, Liu Y, Zhou M, Wang J, Jiang J, Li X, Fan X, Zhang L, Zhang J, Qiu J,Wu Y, Fang C, Sun H, Liu J. Branched-Chain Amino Acid Catabolism Promotes Thrombosis Risk by Enhancing Tropomodulin-3 Propionylation in Platelets.Circulation. 2020;142(1):49-64.
13.Zhenzhen Zhao#*,Yi Wu#*, Junsong Zhou, Fengwu Chen, Aizhen Yang, David Essex*.The transmembrane protein disulfide isomerase TMX1 negatively regulates platelet responses.Blood. 2019;133(3):246-251. (#Equal first author, *corresponding author).(Recommended in F1000Prime. Highlighted by the commentary in Blood: TMX1: a new vascular thiol isomerase. Philip J. Hogg, Blood 2019;133:188-190).
14.Junsong Zhou*, Aizhen Yang, Fengwu Chen, Zhenzhen Zhao, Katsue Suzuki-Inoue, Yukio Ozaki, and Raymond Birge,Yi Wu*. Growth arrest-specific gene 6 receptors, Tyro3, Axl, and Mer, differentially support platelet activation and thrombosis.Cell Communication and Signaling,2018;16(1):98.(*corresponding author).
15.Yi Wu. The plasma contact system as a modulator of innate immunity.Current Opinion in Hematology2018;25(5):389-394.(invited review)
16.David Essex*,Yi Wu*. Multiple Protein Disulfide Isomerases Support Thrombosis.Current Opinion of Hematology2018;25(5):395-402.(*corresponding author, invited review)
17.B. Wang, A. Yang, Z. Zhao,C. He, Y. Liu,R.W. Colman, J. Dai,Y. Wu*.Plasma kallikrein-kininogen pathway is critical in the pathogenesis of colitis in mice.Frontiers in Immunology.2018 Feb 6;9:21.doi: 10.3389/fimmu.2018.00021.(*correspondingauthor).
18.A. Yang, F. Chen, C. He, J. Zhou,Y. Lu, J. Dai, R.B. Birge,Y. Wu*.The pro-coagulant activity of apoptotic cells is mediated by interaction with Factor XII.Frontiers in Immunology,2017,8:1188.(*correspondingauthor).
19.A. Yang, J. Zhou, B. Wang, R.W.Colman, J. Dai, W. Song,Y. Wu*.A critical role for plasma kallikrein in autoantibody-induced arthritis.FASEB Journal.2017;31(12):5419-5431.(*correspondingauthor).
20.J. Zhou#,Y. Wu#*, F. Chen, L. Wang, L. Rauova, V.M. Hayes, M. Poncz, H. Li, T. Liu, J. Liu, D.W. Essex*. The disulfide isomerase ERp72 supports arterial thrombosis.Blood.2017;130(6):817-828. (#Equal first author, *corresponding author).
21.A. Yang, Z. Xie, B. Wang, R.W. Colman, J. Dai,Y. Wu*. An essential role of high-molecular-weight kininogen in endotoxemia.Journal of Experimental Medicine.2017;214(9):2649-2670.(*correspondingauthor).
22.J. Zhou#,Y. Wu#*, L. Wang, L. Rauova, V.M. Hayes, M. Poncz, D.W. Essex*. The C-terminal CGHC motif of protein disulfide isomerase supports thrombosis.Journal of Clinical Investigation.2015;125(12):4391-406. (#Equal first author, *corresponding author).
23.Y. Wu. Contact pathway of coagulation and inflammation.Thrombosis Journal,2015;13:17. doi: 10.1186/s12959-015-0048-y. eCollection 2015. (invited review)
24.S.Kimani, K.Geng, C.Kasikara,G.Sriram,Y. Wu, and R.B. Birge.Phosphatidylserine (PS)and efferocytosis:Does defective PS recognitioncontribute to chronic inflammation and autoimmunity?Frontiers in Immunology,2014;5:566. eCollection 2014. (invited review)
25.J. Zhou,Y.Wu, L. Wang, L. Rauova, V.M. Hayes, M. Poncz and D.W. Essex.The disulfide isomerase ERp57 is required for fibrin deposition in vivo.Journal of Thrombosis and Haemostasis2014;12(11):1890-7.(Equal first author)
26.Z. Xie, J. Dai, A. Yang,Y. Wu. Role of bradykinin in the pathogenesis of anti-collagen antibodies-induced arthritis.Rheumatology2014;53(7):1301-6. (corresponding author)
27.A.Yang,J.Dai,Z.Xie,R.W. Colman, Q.Wu,R.B. Birge andY.Wu.High molecular weight kininogen binds phosphatidylserine and opsonizes urokinase plasminogen activator receptor-mediated efferocytosis.Journal of Immunology2014;192(9):4398-408.(corresponding author)
28.L. Wang,Y.Wu*, J. Zhou, S.S. Ahmad, B. Mutus, N. Garbi, G. Hämmerling, J. Liu, and D.W. Essex*. Platelet-derived ERp57 mediates platelet incorporation into a growing thrombus by regulation of the αIIbβ3 integrin.Blood2013;122(22):3642-50.(Equal first author, *corresponding author)
29.X.Chen, Y.Zhang, Y.Wang, D.Li, L.Zhang, K.Wang, X.Luo, Z.Yang,Y.Wu, J.Liu. PDK1 regulates platelet activation and arterial thrombosis.Blood2013;121(18):3718-26.
30.Y.Wu, S. Ahmad, J. Zhou, L. Wang, M.P. Cully, D.W. Essex. The disulfide isomerase ERp57 mediates platelet aggregation, hemostasis, and thrombosis.Blood2012;119(7):1737-46.
31.J. Dai, A. Agelan, A. Yang, V. Zuluaga, D. Sexton, R.W. Colman,Y.Wu*.A role for activation of the kallikrein-kinin system in the synovial recruitment of endothelial progenitor cells in arthritis.Arthritis & Rheumatism2012;64(11):3574-82. (*corresponding author).
32.Y. Wu. Regulation of endothelial progenitor cell function by plasma kallikrein-kinin system. InVasculogenesis. ISBN 978-953-307-882-3. 2011.33.J. Dai, X. Zhu, M.C. Yoder,Y. Wu*, R.W. Colman. Cleaved high molecular weight kininogen accelerates senescence of endothelial progenitor cells by induction of reactive oxygen species.Arteriosclerosis, Thrombosis and Vascular Biology2011;31(4):883-889.(*corresponding author).
33.Y.Wu*, J. Dai, N.G. Schmuckler, M.C. Yoder, C.M. Overall, R.W. Colman. Cleaved kininogen inhibits endothelial progenitor cell differentiation via suppression of matrix metallopeptidase 2.Journal of Thrombosis and Haemostasis, 2010;8(1):185-93.(*corresponding author).
34.N. Tibrewal*,Y.Wu*, V. D’Mello, R. Akakura, B. Varnum, R.B. Birge. Autophosphorylation of docking site Tyr867 in Mertk allows for dissociation of multiple signaling pathways for the phagocytosis of apoptotic cells and down-modulation of LPS-inducible NF-B transcriptional activation.Journal of Biological Chemistry2008;283(6):3618-27. (*Equal first-author).
35.Y.Wu*,V. Rizzo, Y. Liu, I. Sainz, N. Schmuckler, R.W. Colman. Kininostatin associates with caveolae and inhibitsv3 integrin activation in human umbilical vein endothelial cells.Arteriosclerosis, Thrombosis and Vascular Biology2007;27(9):1968-75. (*corresponding author).
36.Y.Wu,N. Tibrewal, R.B. Birge. Phosphatidylserine recognition by phagocytes: a view to a kill.Trends in Cell Biology2006;16(4):189-97. (Invited review)
37.Y. Wu,S. Singh, M.M. Georgescu, R.B. Birge. A role for Mer tyrosine kinase inv5 integrin-mediated phagocytosis of apoptotic cells.Journal of Cell Science2005;118(3):539-553.
38.Y.Wu,N. Asazuma, K. Satoh, T. Takafuta, Y. Yatomi, M.C. Berndt, and Y. Ozaki. Interaction between von Willebrand factor and glycoprotein Ib activates Src kinase in human platelets: role of phosphoinositide 3-kinase.Blood2003;101(9):3469-3476.
39.Y.Wu,K. Inoue-Suzuki, K. Satoh, N. Asazuma, Y. Yatomi, M.C. Berndt, and Y. Ozaki. Role of Fc receptor-chain in platelet glycoprotein Ib-mediated signaling.Blood2001;97(12):3836-3845.
40.Y.Wu,Y. Ozaki, K. Inoue, K. Satoh, T. Ohmori, Y. Yatomi, K. Owada. Differential activation and redistribution of c-Src and Fyn in platelets, assessed by MoAb specific for C-terminal tyrosine-dephosphorylated c-Src and Fyn.Biochimica et Biophysica Acta-Molecular Cell Research2000;1497:27-36.
荣誉奖励:
1.2019年，血液系统疾病出凝血异常诊疗新策略的建立及推广应用；国家科学技术进步奖 二等奖，排名4。2.2019年苏州市医学会医学科技奖二等奖，排名第一。（凝血系统和二硫键异构酶对血管稳态的网络调控）。
课程教学及招生信息:
1.细胞生物学（本科生课程）