崔凤梅 教授、博士生导师

电话：0512-65880052

传真：0512-65884380

电子邮箱：cuifengmei@suda.edu.cn

通讯地址：苏州工业园区仁爱路199号, 邮编215123

个人简介:

崔凤梅，女，www.优德88.cpm 医学部放射医学与防护学院教授，博士生导师。1998年原苏州医学院放射医学本科毕业留校后一直工作至今。先后获得放射医学硕士和博士学位。2006年和2014年分别赴美国乔治敦大学和UAB访学。2009-2012军事医学科学院放射与辐射医学研究所博士后工作。多年来，从事放射毒理学、放射卫生与防护、辐射损伤修复与辐射防护药物等方面的教学和科研。参与《放射医学》、《核事故医学应急》、《放射毒理学》、《同位素示踪学》、《核与辐射安全漫谈》、《身边的电离辐射》等多门课程的授课。先后主持4项国家自然科学基金和1项国家重点项目，发表论文60余篇，获得3项发明专利。

承担项目:

1.国家自然科学基金委员会，面上项目，81973237，虎杖苷石墨烯水凝胶通过调节肠道细菌Roseburia及其代谢产物5-HIAA救治肠道放射损伤的研究，2020-01至2023-12，56万元，在研，主持

2.军委后勤保障部，重点项目，BEP19J004，核沾染创面处理关键技术研究，2019-07至2022-12，282.2万元，结题，主持

3.国家自然科学基金委员会，面上项目，81573077，Exosomes/miR-7/Bcl-2途径参与电离辐射远位效应的研究，2016-01至2019-12，70万元，结题，主持

4.国家自然科学基金委员会，面上项目，81172706，氚水辐射损伤后P53/miR-34a/myc通路参与的调控机制，2012-01至2015-12，70万元，结题，主持

5.国家自然科学基金委员会，青年项目，30800922，氚内照射损伤的表观遗传学机制的基础研究，2009-01至2011-12，23万元，结题，主持

近五年发表论文（并列第一或通讯）:

1.Cui Fengmei(co-first), Zhang Qixuan, Wan Jun, Sun Liang, Chen Na, Xue Huiyuan, Wang Tianzi, Luo Fajian, Chen Qiu, Tu Yu.Toxic effects of combined exposure of tritiated water and genistein on the growth and development of zebrafish and its mechanism.Frontiers in Environmental Science, 2022(10): DOI=10.3389/fenvs.2022.1001504

2.Li S, Zhang Y, Xue H, Zhang Q, Chen N, Wan J, Sun L, Chen Q, Zong Y, Zhuang F, Gu P, Zhang A,Cui F(co-corresponding), Tu Y. Integrative effects based on behavior, physiology and gene expression of tritiated water on zebrafish. Ecotoxicol Environ Saf. 2021 Sep 15;225:112770.

3.Cui FM(co-first), Wu ZJ, Zhao R, Chen Q, Liu ZY, Zhao Y, Yan HB, Shen GL, Tu Y, Zhou DH, Diwu J, Hou J, Hu L, Wang GJ. Development and Characterization of a Novel Hydrogel for the Decontaminating of Radionuclide-Contaminated Skin Wounds. Macromol Biosci. 2021;21(5):e2000399. doi: 10.1002/mabi.202000399. Epub 2021 Mar 3.

4.Chen H, Chen N, Li F, Sun L, Du J, Chen Y, Cheng F, Li Y, Tian S, Jiang Q, Cui F(co-corresponding), Tu Y. Repeated radon exposure induced lung injury and epithelial-mesenchymal transition through the PI3K/AKT/mTOR pathway in human bronchial epithelial cells and mice. Toxicol Lett. 2020 Nov 1; 334: 4-13. doi: 10.1016/j.toxlet.2020.09.008

5.Yan R, Cui F(co-first), Dong L, Liu Y, Chen X, Fan R. Repression of PCGF1 Decreases the Proliferation of Glioblastoma Cells in Association with Inactivation of c-Myc Signaling Pathway. Onco Targets Ther. 2020; 13: 253-261. doi: 10.2147/OTT.S234517

6.Jin LY, Zhao K, Xu LJ, Zhao RX, Werle KD, Wang Y, Liu XL, Chen Q, Wu ZJ, Zhang K, Zhao Y, Jiang GQ, Cui FM(co-corresponding), Xu ZX. LKB1 inactivation leads to centromere defects and genome instability via p53-dependent upregulation of survivin. Aging (Albany NY). 2020 Jul 16;12(14):14341-14354. doi: 10.18632/aging

7.Yan HB, Liu YT, Li ZY, Wu ZJ, Zhang M, Xue PJ, Liu YL, Wang KZ, He YM, Tu Y, Cui FM(co-corresponding), Chen Q. Tritiated Water Induces Toxicity in Human Umbilical Vein Vascular Endothelial Cells via IL8. Dose Response. 2020 Jul 7;18(3):1559325820938541. doi: 10.1177/1559325820938541.

8.Wang KZ, Sun L, Xiong KH, Chen WB, Wang YY, Bian HH,Cui FM(co-corresponding)*, Liu YL. Monitoring of Tritium Internal Exposure Doses of Heavy-Water Reactor Workers in Third Qinshan Nuclear Power Plant. Dose Response. 2019;17(4):1559325819890498. doi: 10.1177/1559325819890498. eCollection 2019 Oct-Dec.

9.Qiu Chen, Ya-Nan Zeng, Ke Zhang, Ying Zhao, Yong-You Wu, Gen Li, Hui-Ying Cheng, Meng Zhang, Feng Lai, Jin-Bing Wang,Feng-Mei Cui(co-corresponding).Polydatin Increases Radiosensitivity by Inducing Apoptosis of Stem Cells in Colorectal Cancer. Int J Biol Sci 2019; 15(2):430-440. doi:10.7150/ijbs.27050

10.Cui F(co-first), Ma N, Han X, Chen N, Xi Y, Yuan W, Xu Y, Han J, Xu X, Tu Y. Effects of 60Co γ Irradiation on the Reproductive Function of Caenorhabditis elegans. Dose Response. 2019; 17(1):1559325818820981. doi: 10.1177/1559325818820981. eCollection 2019 Jan-Mar.

11.Liu X, Chen Q, Ding X, Zhao Y, Zhang K, Yu P, Cui F(co-corresponding), Xue B. X-ray-induced reproductive dysfunction and differentially expressed piRNAs in male mice. Hum Exp Toxicol. 2018;38(5) 533–546

12.Zuo X, Chen Q, Li H, Zhang K, Wang K, Tu Y, Hu M, Cui F(co-corresponding), Liu Y. Effects of Chahuangjing on Decorporation and Radiation Protection Against Tritiated Water. Dose Response. 2018;16(4):1559325818810650. doi: 10.1177/1559325818810650.

13.Li Li, Ke Zhang, Ji Zhang, Ya-Nan Zeng, Feng Lai, Gen Li, Na Ma, Ming-Jiang Hu,Feng-Mei Cui(co-corresponding), Qiu Chen.Protective effect of polydatin on radiation-induced injury of intestinal epithelial and endothelial cells. Bioscience Reports, 2018; 38 (6) BSR20180868; DOI: 10.1042/BSR20180868

14.Cui FM, Fang F, He YM, Cai DP, He J, Yang XJ. Establishing age and sex dependent upper reference limits for the plasma lipoprotein (a) in a Chinese health check-up population and according to its relative risk of primary myocardial infarction. Clin Chim Acta. 2018; 484:232-236. doi: 10.1016/j.cca.2018.06.004. Epub 2018 Jun 5.

15.Feng Mei Cui, Xiu Jin Sun, Cheng Cheng Huang, Qiu Chen, Yong Ming He, Shi Meng Zhang, Hua Guan, Man Song, Ping Kun Zhou*, Jun Hou*.Inhibition of c-Myc expression accounts for an increase in the number of multinucleated cells in human cervical epithelial cells.Oncol Lett. 2017; 14(3): 2878–2886.

16.Shang Cai, Geng-Sheng Shi, Hui-Ying Cheng, Ya-Nan Zeng, Gen Li, Meng Zhang, Man Song, Ping-Kun Zhou, Ye Tian,Feng-Mei Cui*, Qiu Chen*.Exosomal miR-7 Mediates Bystander Autophagy in Lung after Focal Brain Irradiation in Mice.Int J Biol Sci. 2017; 13(10): 1287–1296.

17.Cui F, Hou J, Huang C, Sun X, Zeng Y, Cheng H, Wang H, Li C*. C-Myc regulates radiation-induced G2/M cell cycle arrest and cell death in human cervical cancer cells. J Obstet Gynaecol Res. 2017;43(4):729-735. doi: 10.1111/jog.13261.