陈秋教授放射生物学教研室

E-mail:happyqiu@suda.edu.cn

研究方向：

1、免疫细胞在电离辐射诱导肠道损伤中的作用和机制

2、新基因在电离辐射诱导肠道损伤中的作用和机制

3、药物在电离辐射诱导肠道损伤和结直肠癌放疗中的作用和机制

近年研究成果：

1、Yan HB, Liu YT, Li ZY, Wu ZJ, Zhang M, Xue PJ, Liu YL, Wang KZ, He YM, Tu Y, Cui FM*,Chen Q*. Tritiated Water Induces Toxicity in Human Umbilical Vein Vascular Endothelial Cells via IL8. Dose Response. 2020 Jul 7;18(3):1559325820938541.

2、Chen W, Li H, Wang K, Bian H, Wang Y, Cui F, Liu Y*,Chen Q*. Medical Treatment and Dose Estimation of a Person Exposed to Tritium. Dose Response. 2019 Oct 15;17(4):1559325819880670.

3、Liu X,Chen Q, Ding X, Zhao Y, Zhang K, Yu P, Cui F*, Xue B*. X-ray-induced reproductive dysfunction and differentially expressed piRNAs in male mice. Hum Exp Toxicol. 2019 May;38(5):533-546.

4、Chen Q^#, Zeng YN^#, Zhang K^#, Zhao Y, Wu YY, Li G, Cheng HY, Zhang M, Lai F, Wang JB*, Cui FM*. Polydatin Increases Radiosensitivity by Inducing Apoptosis of Stem Cells in Colorectal Cancer. Int J Biol Sci. 2019 Jan 1;15(2):430-440.

5、Li L^#, Zhang K^#, Zhang J^#, Zeng YN, Lai F, Li G, Ma N, Hu MJ, Cui FM*,Chen Q*. Protective effect of polydatin on radiation-induced injury of intestinal epithelial and endothelial cells. Biosci Rep. 2018 Nov 13;38(6). pii: BSR20180868. doi: 10.1042/BSR20180868. Print 2018 Dec 21.

6、Cai S^#, Shi GS^#, Cheng HY, Zeng YN, Li G, Zhang M, Song M, Zhou PK, Tian Y, Cui FM*,Chen Q*. Exosomal miR-7 Mediates Bystander Autophagy in Lung after Focal Brain Irradiation in Mice. Int J Biol Sci. 2017 Sep 21;13(10):1287-1296.

7、Gen Li^#, Anqing Wu^#, Dandan Qi^#, Fengmei Cui^#, Yanan Zeng^#, Fang Xie, Hongya Wu, Yongping Gu,Qiu Chen*, Xueguang Zhang*. Differential effects of peptidoglycan on colorectal tumors and intestinal tissue post-pelvic radiotherapy,Oncotarget,2016, 7(46): 75685-75697.

主持项目：

1、国家自然科学基金面上项目，81773355，肠道隐窝干细胞招募固有层巨噬细胞合作修复放射性肠损伤的机制研究，2018/01- 2021/12，60.00万，在研，主持。

2、国家自然科学基金面上项目，81372920，云芝多糖通过TLR2/Akt途径防治小肠辐射损伤的机制研究，2014/01-2017/12，85万元，已结题，主持。