张晗

张晗

副教授，硕士生导师

2019年获山东大学博士学位，2019年至2022年在www.优德88.cpm 功能纳米与软物质研究院从事博士后研究工作。2022年加入www.优德88.cpm 药学院，被聘为副教授，同年入选“www.优德88.cpm 优秀青年学者”。

联系方式：hanzhang@suda.edu.cn

研究领域：活性生物材料；仿生纳米技术；大分子药物递送体系；粘膜相关疾病的局部给药系统；疾病的免疫疗法

主要成果和贡献：

致力于生物、材料、物理、化学和医学的交叉领域，针对生命科学与临床医学中的重要科学问题，发展了一系列新型高效的生物材料，研究了其在抗病毒、抗炎与抗肿瘤等方面的应用；设计构建了多种新型的大分子药物（抗体、细胞因子、酶、核酸等）递送体系，深入研究了其跨屏障递送机制，并探索了其在眼睛、口腔、膀胱等粘膜相关疾病中的应用。在PNAS，ACS Nano，Biomaterials，J. Control. Release等期刊发表第一作者论文十余篇。主持中国博士后基金面上项目、江苏省博士后科研项目和国家自然科学基金青年科学基金项目共3项。

代表性论文：

1. Han Zhang*, Yanbin Liu, Zhuang Liu*, Nanomedicine approaches against SARS-CoV-2 and variants.J. Control. Release2024, 365, 101-111.

2. Yutong Jiang, Xuehui Fu, Ming Shao, Wanwan Chang, Han Zhang*, Zhuang Liu*, Eyedrop delivery of therapeutic proteins with zwitterionic polymers to treat dry age-related macular degeneration.Biomaterials2024, 305, 122429.

3. Han Zhang, Wenjun Zhu, Qiutong Jin, Feng Pan, Jiafei Zhu, Yanbin Liu, Linfu Chen, Jingjing Shen, Yang Yang*, Qian Chen*, Zhuang Liu*, Inhalable nanocatchers for SARS-CoV-2 inhibition.Proc. Natl. Acad. Sci. U.S.A.2021, 118, e2102957118.

4.Han Zhang, Kai Liu, Yimou Gong, Wenjun Zhu, Jiafei Zhu, Feng Pan, Yu Chao, Zhishen Xiao, Yanbin Liu, Xianwen Wang, Zhuang Liu, Yang Yang*, Qian Chen*,Vitamin C supramolecular hydrogel for enhanced cancer immunotherapy.Biomaterials2022, 287, 121673.

5.Han Zhang, Jiafei Zhu, Tianxu Fang, Meng Li, Guojun Chen*, Qian Chen*, Supramolecular biomaterials for enhanced cancer immunotherapy.J. Mater. Chem. B2022,10, 7183-7193.

6. Han Zhang, Kai Liu, Shukun Li, Xia Xin*, Shiling Yuan*, Guanghui Ma, Xuehai Yan*, Self-Assembled Minimalist Multifunctional Theranostic Nanoplatform for Magnetic Resonance Imaging-Guided Tumor Photodynamic Therapy.ACS Nano2018, 12, 8266-8276.

7. Han Zhang, Lei Kang, Qianli Zou, Xia Xin, Xuehai Yan*, Coordination-assembled supramolecular nanoplatforms: structural modulation and theranostic applications.Curr. Opin. Biotech.2019, 58, 45-52.

8. Yuankai Zhang, Han Zhang(Co-first author), Qianli Zou, Ruirui Xing, Tingfeng Jiao, Xuehai Yan*, An injectable dipeptide–fullerene supramolecular hydrogel for photodynamic antibacterial therapy.J. Mater. Chem. B2018, 6, 7335-7342.

9. Han Zhang, Lingyu Guo, Jianmei Jiao, Xia Xin*, Di Sun, Shiling Yuan*, Ionic Self-Assembly of Polyoxometalate Dopamine Hybrid Nanoflowers with Excellent Catalytic Activity for Dyes.ACS Sustain. Chem. Eng.2017, 5, 1358-1367.

10. Han Zhang, Xia Xin*, Jichao Sun, Liupeng Zhao, Jinglin Shen, Zhaohua Song, Shiling Yuan*, Self-assembled chiral helical nanofibers by amphiphilic dipeptide derived from D- or L-threonine and application as a template for the synthesis of Au and Ag nanoparticles.J Colloid Interf. Sci.2016, 484, 97-106.

11. Han Zhang, Lingyu Guo, Zengchun Xie, Xia Xin*, Di Sun, Shiling Yuan*, Tunable Aggregation-Induced Emission of Polyoxometalates via Amino Acid-Directed Self-Assembly and Their Application in Detecting Dopamine.Langmuir2016, 32, 13736-13745.

12. Han Zhang, Menghong Yu, Aixin Song, Yawen Song, Xia Xin*, Jinglin Shen, Shiling Yuan*, Modulating hierarchical self-assembly behavior of a peptide amphiphile/nonionic surfactant mixed system.RSC Adv.2016, 6, 9186-9193.

13. Han Zhang, Jichao Sun, Xia Xin*, Wenlong Xu, Jinglin Shen, Zhaohua Song, Shiling Yuan*, Modulating self-assembly behavior of a salt-free peptide amphiphile (PA) and zwitterionic surfactant mixed system.J Colloid Interf. Sci.2016, 467, 43-50.