丁大伟

姓名：丁大伟

职称：特聘教授

电子邮箱：dawei.ding@suda.edu.cn

办公地址：云轩楼2114

个人简介

一、学习工作经历

1、学历背景

2011.8-2015.7新加坡南洋理工大学材料科学与工程，博士

2008.9-2011.6南京大学药剂学，硕士

2004.9-2008.6南京大学生物技术，本科

2.工作经历

2019.6-www.优德88.cpm 药学院，特聘教授

2016.8-2019.6新加坡-麻省理工学院联合研究中心（SMART），博士后

2015.8-2016.6新加坡南洋理工大学，材料科学与工程学院，研究助理/博士后

二、研究方向

1、肿瘤的纳米给药联合治疗系统

2、用于糖尿病和肿瘤的治疗的微针给药系统

3、眼部及口服给药系统

4、微流控技术及其在生物医学中的应用

三、代表性研究成果

在药物递送与生物材料领域发表学术论文10余篇，授权国际及国内专利4项。

1、发表论文（按中科院分区，*通讯作者）

[1] Mengying He, Tao Yang, Yuhan Wang, Mengyuan Wang, Xinye Chen,Dawei Ding*, Yiran Zheng*, Huabing Chen*, Immune Checkpoint Inhibitor-Based Strategies for Synergistic Cancer Therapy.Adv. Healthcare Mater.2021,https://doi.org/10.1002/adhm.202002104(IF=7.4, I区Top).

[2] Haroon Iqbal, Tao Yang, Ting Li, Miya Zhang, Hengte Ke,Dawei Ding,Yibin Deng* and Huabing Chen*, Serum Protein-Based Nanoparticles for Cancer Diagnosis and Treatment.J. Control. Release, 2021, 329, 997-1022(IF=7.7, I区Top).

[3] Dawei Dinget al., A Miniaturized Device for Biomembrane Permeation Analysis.Mater. Sci. Eng. C2019, 103, 109772(IF=5.9, II区).

[4] Dawei Dinget al., Design of Mucoadhesive PLGA Microparticles for Ocular Drug Delivery.ACS Appl. Bio Mater.2018, 1, 561−571.

[5] Dawei Dinget al., Recent Advances of PLGA Micro/nanoparticles for the Delivery of Biomacromolecular Therapeutics.Mater. Sci. Eng. C2018, 92, 1041-1060(IF=5.9, II区).

[6] Dawei Dinget al., Squid Suckerin Microneedle Arrays for Tunable Drug Release.J. Mater. Chem. B2017,5, 8467-8478(Highlighted on the back cover, IF=5.3, II区).

[7] Yuan Ping^#,Dawei Ding^#et al., Supramolecular β-sheets Stabilized Protein Nanocarriers for Drug Delivery and Gene Transfection.ACS Nano2017, 11, 4528-4541 (^#Co-first author,IF=14.6，, I区Top).

[8] Dawei Dinget al., From Soft Self-Healing Gels to Stiff Films in Suckerin-Based Materials through Modulation of Crosslink Density and β-Sheet Content.Adv. Mater.2015, 27, 3953-3961(IF=27.4, I区Top).

[9] Dawei Dinget al., Biomimetic Production of Silk-Like Recombinant Squid Sucker Ring Teeth Proteins.Biomacromolecules2014, 15, 3278−3289(IF=6.1, II区Top).

[10] Dawei Dinget al., Novel Self-assembly Endows Human Serum Albumin Nanoparticles with an Enhanced Antitumor Efficacy.AAPS PharmSciTech2014, 15, 213-222(IF=2.4, III区).

[11] Victoria Latza, Paul Guerette,Dawei Dinget al., Multi-Scale Thermal Stability of a Hard Thermoplastic Protein-Based Material.Nat. Commun.2015, 6, 8313(IF=12.1, I区Top).

[12] Bram Cantaert,Dawei Dinget al., Stable Formation of Gold Nanoparticles onto Redox-Active Solid Bio-Substrates Made of Squid Suckerin Proteins.Macromol. Rapid Commun.2015, 36, 1877-1883(IF=4.9, II区).

[13] Paul Guerette, Shawn Hoon,Dawei Dinget al., Nanoconfined β-Sheets Mechanically Reinforce the Supra-Biomolecular Network of Robust Squid Sucker Ring Teeth.ACS Nano2014, 8, 7170-7179(IF=14.6, I区Top).

[14] Paul Gueretteet al.,Dawei Ding, Ali Miserez, Accelerating the design of biomimetic materials by integrating RNA-seq with proteomics and materials science.Nat. Biotechnol.2013, 31, 908-918(IF=36.6, 1区Top).

[15] Jinhui Wu,Dawei Dinget al., Sustained delivery of endostatin improves the efficacy of therapy in Lewis lung cancer model.J. Control. Release2009, 134, 91-97(IF=7.7, I区Top).

2、授权专利

[1] 胡一桥、吴锦慧、丁大伟等，一种用于制备体内递送药理活性物质的蛋白纳米粒的方法，中国发明专利ZL 2010 1 0247885.7，已授权。

[2] Yiqiao Hu, Jinhui Wu,Dawei Dinget al., Methods for Drug Delivery Comprising Unfolding and Refolding Proteins and Peptide Nanoparticles，美国发明专利US 9066870 B2，已授权。

[3] Yiqiao Hu, Jinhui Wu,Dawei Dinget al., Drug delivery method utilizing unfolding and folding of proteins and peptide nanoparticles，日本发明专利JP 5570599B2，已授权。

[4] Yiqiao Hu, Jinhui Wu,Dawei Dinget al., Methods for Drug Delivery Comprising Unfolding and Folding Proteins and Peptide Nanoparticles，欧洲发明专利EP2464224B，已授权。