张真庆

姓名：张真庆

职称：www.优德88.cpm 特聘教授， 江苏特聘 教授

联系电话：0512-65882593

电子邮箱：z_zhang@suda.edu.cn

办公地址：苏大独墅湖校区2期云轩楼1129

张真庆 教授简介

一、学习工作经历

1、学历背景

1996.09 - 2000.06：中国海洋大学，药学

2000.09 - 2006.06：中国海洋大学，工学博士，研究方向糖科学

2、工作经历

2006.08 - 2009.09：美国Rensselaer Polytechnic Institute,博士后

2009.10 –2012.08：美国Baxter Healthcare,研究员

2012.08 –目前：www.优德88.cpm 药学院，教授

二、研究方向

1、糖药物结构、制备工艺、质量控制

2、糖药物-免疫学构效关系研究

3、糖药物-神经退行性疾病构效关系研究

4、肝素类药物糖组学研究

5、抗体药物糖基化研究发

三、主要研究成果

1、论文

(1) J. Hao, F. Wu, R. Tang, Y. Sun, D. Liu,^*Z. Zhang^a*Preparation of 1,4-linked α-D-glucuronans from starch with 4-acetamide-TEMPO/NaClO2/NaClO system,International Journal of Biological Macromolecules,2020in press. 2区,IF4.8

(2)D. Bi, X. Li, T. Li, X. Li, Z. Lin, L. Yao, H. Li, H. Xu, Z. Hu,Z. Zhang*, Q. Liu* and X Xu* Characterization and Neuroprotection Potential of Seleno-Polymannuronate,Frontiers in Pharmacology,2020,11: 21, 2区，IF3.8

(3)Y. Meng, L. Yi, L. Chen, J. Hao, D. Li, J. Xue*, N. Xu,Z.Zhang*. Purification, structure characterization and antioxidant activity of polysaccharides from Saposhnikovia divaricate,Chinese Journal of Natural Medicines.2019, 17(10): 0792-0800,4区，IF:1.991

(4)Y. Ouyang, M. Zhu, X.Wang, L. Yi, Y. Yao, J. Fareed, R. J Linhardt*,Z. Zhang,*Systematic analysis of enoxaparins from different sources with online one and two-dimensional chromatography,Analyst.2019,144, 3746-3755.2区，IF 4.019

(5)Y. Ouyang, Y. Yu, F. Zhang, J. Chen, X. Han, K. Xia, Y.Yao,Z. Zhang,* R.J. Linhardt*, Non-Anticoagulant Low Molecular Weight Heparins for Pharmaceutical Applications,Journal Medicinal Chemistry, 2019,62, 1067-1073.2区，IF 6.054.

(6)Y. Ouyang, X. Han, Q. Xia, J. Chen, S. Velagapudi, K. Xia,Z. Zhang^*and R.J Linhardt^*Negative-ion Mode Capillary Isoelectric Focusing-Mass Spectrometry for Charge-Based Separation of Acidic Oligosaccharides,Analytical Chemistry,2019,91, 846-853. 1区，IF 6.35

(7)R. Cheng, X. Tang, A. Long, J. Mwangi, R. Lai, R. Sun, C. Long,Z. Zhang^*. Purification and characterization of a novel anti-coagulant from the leech Hirudinaria manillensis.Zoological Research. 2019, 40(3): 205-210.

(8)F. Wu，K. Dong, M. Zhu, Q. Zhang, B. Xie, D. Li, H.Gan,Z. Zhang*Development of a method to analyze the complexes of enoxaparin and plateletfactor 4 with size-exclusion chromatography,Jounral of Pharmaceutical and Biomedical Analysis,2019,164, 668-671. 3区，IF 2.983

(9)Y. Ouyang, X. Han, Y. Yu, J. Chen, L. Fu, F. Zhang, R. Linhardt, J. Fareed, D. Hoppensteadt, W. Jeske, A. Kouta,Z. Zhang,*K. Xia*. Chemometric analysis of porcine, bovine and ovine heparins,Jounral of Pharmaceutical and Biomedical Analysis,2019,164, 345-352. 3区，IF 2.983

(10)Y. Lin, Q. Zhang, Y. Meng, J. Hao, B. Xie, H. Gan, D. Li, K. Dong,Z. Zhang*Qualitative and quantitative analysis of 2, 5-anhydro-D-mannitol in low molecular weight heparins with high performance anion exchange chromatography hyphenated quadrupole time of flight mass spectrometry,Journal of Chromatography A.2018,1569:160-167. 2区，IF 3.858

(11)Z. Liu, Y. Xiong, L. Yi, R. Dai, Y. Wang, M. Sun, X. Xiao,Z. Zhang*, S. Yuan*,Endo-β-1,3-glucanase digestion combined with the HPAEC-PAD-MS/MS analysis reveals the structural differences between two laminarins with different bioactivities,Carbohydrate Polymers,2018,194, 339-349. 2区，IF:6.044

(12)R. Tang¹, J. Hao¹, R.Zong, F. Wu, Y. Zeng,Z. Zhang*,Oxidation pattern of curdlan with TEMPO-mediated system,Carbohydrate Polymers,2018,186, 9-16.2区，IF: 6.044

(13)Y. Ouyang, Y. Zeng, L. Yi, H. Tang, D. Li, R. Linhardt,Z. Zhang*Qualitative and quantitative analysis of heparin and low molecular weight heparins using size exclusion chromatography with multiple angle laser scattering/refractive index and inductively coupled plasma/mass spectrometry detectors,Journal of Chromatography A.2017, 1522(3): 56-61, 2区，IF 3.858

(14)L. Xu, Z. Zhang*, X. Sun, J. Wang, W. Xu, L. Shi, J. Lu, J. Tang, J. Liu, X. Su.Glycosylation status of bone sialoprotein and its role in mineralization,Exp Cell Res.2017(17):30514-1. 2区，IF 3.329

(15)Y. Rong, N Xu, B Xie, J Hao, L Yi, R Cheng, D Li, R. J. Linhardt,Z. Zhang,* Sequencing analysis of β-glucan from highland barley with high performance anion exchange chromatography coupled to quadrupole time – of – flight mass spectrometry,Food Hydrocolliods,2017, 73, 235-242. 2区，IF:5.839

(16)X. Sun, L. Tao, L. Yi, Y. Ouyang, N. Xu, D. Li, R. Linhardt,Z. Zhang*N-glycans released from glycoproteins using a commercial kit andcomprehensively analyzed with a hypothetical database,Journal of Pharmaceutical Analysis,2017, 7(2): 87-94.IF: 4.44

(17)L. Tao, F. Song, N. Xu, D. Li, R.J. Linhardt,Z. Zhang*New Insights into the Action of Bacterial Chondroitinase AC I and Hyaluronidase on Hyaluronic Acid,Carbohydrate Polymers,2017,158: 85-92.2区，IF: 6.044

(18)J. Hao, S. Xu, N. Xu, D. Li, R.J Linhardt,Z. Zhang*Impact of Degree of Oxidation on the Physicochemical Properties of Microcrystalline CelluloseCarbohydrate Polymers,2017, 155, 483-490.2区，IF: 6.044

(19)J. Hao, J. Lu, N. Xu, R. J. Linhardt,Z. Zhang^*Specific oxidation pattern of soluble starch with TEMPO-NaBr-NaClO system,Carbohydrate Polymers,2016, 146:238-244,2区，IF: 6.044

(20)Y. Ouyang, C. Wu, X. Sun, J. Liu, R. J. Linhardt,Z. Zhang*. Development of Hydrophilic-Interaction-Chromatography with Quadruple-Time-of-Flight Mass Spectrometry for Heparin and Low-Molecular-Weight-Heparin Disaccharide Analysis,Rapid communications in mass spectrometry,2016,30,277-284. 4区，IF: 2.045

(21)L. Yi, Y. Ouyang, X. Sun,N. Xu, R. J. Linhardt,Z. Zhang*Qualitative and quantitative analysis of branches in dextran using high-performance anion exchange chromatography coupled to quadrupole time-of-flight mass spectrometry,Journal of Chromatography A.,2015, 1423:79-85.2区，IF 3.858

(22)Y. Ouyang, Y. Zeng, Y. Rong, Y. Song, L. Shi, B. Chen, X. Yang, N. Xu, R. J. Linhardt,Z. Zhang* Profiling Analysis of Low Molecular Weight Heparins by Multiple Heart-Cutting Two Dimensional Chromatography with Quadruple Time-of-Flight Mass Spectrometry,Analytical Chemistry,2015, 87(17): 8957-8963.1区，IF 6.35

(23)C. Wu, J. Liu,Z. Zhang^*Hydrophilic interaction liquid chromatography- quadrupole-time-of-flight mass spectrometry analysis of glycosaminoglycan oligosaccharides,Chinese Journal of Analytical Chemistry,2015, 43(8):1198-1202.4区，IF: 0.931

(24)L. Yi, X Sun, K. Du, Y. Ouyang, C. Wu, N. Xu, R. J. Linhardt,Z. Zhang*,UP-HILIC-MS/MS to Determine the Action Pattern ofPenicillium sp.Dextranase,Journal of American Society for Mass Spectrometry,2015, 26, 1174-1185.3区，IF: 3.202

(25)J. Lu, H. Yang, J. Hao, C. Wu, L. Liu, N. Xu, R. J. Linhardt,Z. Zhang*, Impact of hydrolysis conditions on the detection of mannuronic to guluronic acid ratio in alginate and its derivatives,Carbohydrate Polymers,2015, 122, 180–188, 2区，IF: 6.044

(26)Z. Zhang, S. Till,S. Knappe, C. Quinn, J. Catarello, G. J. Ray, F. Scheiflinger, C. M. Szabo, M. Dockal*, Screening of Complex Fucoidans from Four Brown Algae Species as Procoagulant AgentsCarbohydrate Polymers,Carbohydrate Polymers.2015,115, 677-685,IF:2区，IF: 6.044

2、已授权专利

1.不饱和透明质酸奇数寡糖及其制备方法，CN201611020047.X，排名1

2.一种氧化型β-1,4-寡聚葡萄糖醛酸及其制备方法和用途，CN201611020047.X，排名1

3.一种氧化型α-1,4-寡聚葡萄糖醛酸及其制备方法和用途，201510267211.6，排名1

4. Factor VIII half-life extension by polysialic acid，13/803,594，排名2

5. Drug candidate screening and structure-activity relationship of a non-anticoagulant sulfated polysaccharide，61/683,144，排名3

3、软件著作

Glycomapping v1.0（This software is patented and its copyright belongs to Soochow University. It is free for research purpose.）

Glycomapping v1.0 Install.zip