王光辉

姓　　名：王光辉

职称职务：教授、博导

联系电话：65884845

电子邮箱：wanggh@suda.edu.cn

办公地址：云轩楼2405

个人简介：

一、学习工作经历

1、学历背景：

1981.9-1987.7上海医科大学本科

1987.9-1990.7上海医科大学组织胚胎学硕士生

1997.4-2001.3日本东京大学医学部神经内科Ph.D

2001.4-2001.10新加坡国立大学博士后

2001.11-2003.8美国依阿华大学医学院博士后

2、国外学习研究经历：

1995.10-1997.3日本东京大学附属医院访问学者

3、工作经历：

1990.8-1995.9上海医科大学组织胚胎学助教、讲师

2003.10-2011.5中国科学技术大学教授、博导

2011.5-至今www.优德88.cpm 药学院教授、博导

二、研究方向

1）帕金森病中的线粒体损伤和清除的机制

2）帕金森病中神经元与胶质细胞相互作用在疾病发生中的作用

3）神经退行性疾病相关蛋白的功能和机制研究

三、近年来主要研究成果

近年来，在EMBO J、Mol Psychiatry、Cell Death Differ、Brain、Hum Mol Genet、Oncogene、Cell Death Dis、Science Signaling和JBC等期刊发表通讯作者论文60余篇，其中，2010年发表在Cell Death Differ上关于帕金森病的线粒体蛋白Omi与自噬的论文被Nature网站列为神经科学特色论文；2011年发表在Mol Psychiatry上有关精神分裂症dysbindin在神经发育中的机制研究被选为封面论文；2012年发表的帕金森病蛋白Omi调控小胶质细胞激活的研究以封面论文发表在Science子刊Science Signaling上，并受到该杂志电话采访，也被Nature Immunology编辑Laurie Dempsey作为研究亮点在Nature Immunology评述。2016年发表在EMBO J上的有关TDP-43与自噬的研究被列为封面论文，并被该期刊专题评述。

一）近年来代表性通讯作者论文

1. Mao J, Xia Q, Liu C, Ying Z, Wang H, Wang G. A critical role of Hrd1 in the regulation of optineurin degradation and aggresome formation.Hum Mol Genet.2017;26: 1877-1889.

2. Gu C, Zhang Y, Hu Q, Wu J, Ren H, Liu CF, et al. P7C3 inhibits GSK3beta activation to protect dopaminergic neurons against neurotoxin-induced cell death in vitro and in vivo.Cell Death Dis.2017; 8: e2858.

3. Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, Ren H, Chen D, Han J, Ying Z*,Wang G*. TDP-43 loss of fuction increases TFEB activity and blocks autophagosome-lysosome fusion.EMBO J.2016; 35:121-142.（封面论文）

4. Xia Q, , Wang H, Hu Q, Ying Z*,Wang G*. Folliculin, a tumor suppressor associated with Birt-Hogg-Dube (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation.Hum Mol Genet.2016; 25: 83-96.

5. Ying Z, Xia Q, Hao Z, Xu D, Wang M, Wang H, Wang G*. TARDBP/TDP-43 regulates autophagy in both MTORC1-dependent and MTORC1-independent manners.Autophagy .2016,4,707-708.

6. Tao Z, Wang H, Xia Q, Li K, Li K, Jiang X, Xu G,Wang G*, Ying Z*. Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.Hum Mol Genet,2015, 24: 2426-41.

7. Gao F, Chen D, Si J, Hu Q, Fang M andWang G*.Impairment of Nix-mediated mitophagy is linked to the pathogenesis of Parkinson's disease.Hum Mol Genet,2015, 24: 2528-38.

8. Zhou L, Wang H, Ren H, Hu Q, Ying Z*,Wang G.*Bcl-2 Decreases the Affinity of SQSTM1/p62 to Poly-Ubiquitin Chains and Suppresses the Aggregation of Misfolded Protein in Neurodegenerative Disease.Mol Neurobiol.2015, 52:1180-9.

9. Xu R, Hu Q, Ma Q, Liu C,Wang G*.The protease Omi regulates mitochondrial biogenesis through the GSK3b/PGC-1a pathway.Cell Death and Dis.2014, 5:e1373.

10. Ren H, Fu K, Mu C, Zhen X,Wang G*.L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL.Mol Neurodegener.2012, 7:40.

11. Hu Q, Li B, Xu R, Chen D, Mu C, Fei E,Wang G*The Protease Omi Cleaves the Mitogen-Activated Protein Kinase Kinase MEK1 to Inhibit Microglial Activation.Science Signal.2012, 5:ra61.（封面论文，并被该杂志电话采访）

12. Wang H, Ying Z,Wang G* Ataxin-3 Regulates Aggresome Formation of Copper-Zinc Superoxide Dismutase (SOD1) by Editing K63-linked Polyubiquitin Chains.J Biol Chem.2012, 287:28576-28585.

13. Ren H, Fu K, Wang D, Mu C,Wang G*Oxidized DJ-1 interacts with the mitochondrial protein BCL-XL.J Biol Chem.2011,286: 35308-35317.

14. Fu K, Ren H, Wang Y, Fei E, Wang H,Wang G*DJ-1 inhibits TRAIL-induced apoptosis by blocking pro-caspase-8 recruitment to FADD.Oncogene.2011, 31:1311-1322.

15. Ma X, Fei E, Fu C, Ren H,Wang G*Dysbindin-1, a schizophrenia-related protein, facilitates neurite outgrowth by promoting the transcriptional activity of p53.Mol Psychiatry.2011, 16:1105-1116.（封面论文）

16. Ying Z, Wang H*, Fan H,Wang G*The ER-associated degradation system regulates aggregation and degradation of mutant neuroserpin.J Biol Chem.2011, 286: 20835-20844.

17. Fei E, Ma X, Zhu C, Xue T, Yan J, Xu Y, Zhou J,Wang G*Nucleocytoplasmic shuttling of dysbindin-1, a schizophrenia related protein, regulates synapsin I expression.J Biol Chem.2010285：38630-38640.

18. Chen D, Gao F, Li B, Wang H, Xu Y, Zhu C,Wang G*Parkin mono-ubiquitinates BCL-2 and regulates autophagy.J Biol Chem.2010, 285：38214-38223.

19. Li B, Hu Q, Wang H, Man N, Ren H, Wen L, Nukina N, Fei N,Wang G*Omi/HtrA2 is a positive regulator of autophagy that facilitates the degradation of mutant proteins involved in neurodegenerative diseases.Cell Death & Differ2010,17:1751-1759.

20. Ren H, Fu K, Mu C, Li B, Wang D,Wang G*DJ-1, a cancer and Parkinson’s disease associated protein, regulates autophagy through JNK pathway in cancer cells.Cancer Lett2010, 297:101-108.

21. Zhou T, Wang S, Ren H, Qi X, Luchetti S, Kamphuis W, Zhou J,Wang G* and Swaab D*Dendritic cell nuclear protein-1, a novel depression-related protein, upregulates corticotropin-releasing hormone expression.Brain2010, 133: 3069-3079.

22. Fan J, Ren H, Jia N, Fei E, Zhou T, Jiang P, Wu M, Wang G* DJ-1 Decreases Bax Expression through Repressing p53 Transcriptional Activity.J Biol Chem2008, 283:4022-4030.

23. Liu C, Fei E, Jia N, Wang H, Tao R, Iwata A, Nukina N, Zhou J, and Wang G*Assembly of lysine 63 linked ubiquitin-conjugates by phosphorylated alpha-synuclein implies Lewy body biogenesis.J Biol Chem2007, 282:14558-14566

二）近年来主持的课题

1)项目来源：国家自然基金国际合作项目(81761148024)

课题名称：具有抗帕金森病的小分子化合物的筛选和鉴定

起止时间：2017/01-2019/12

资助经费: 200万元

2)项目来源：国家自然科学基金重点项目（31330030）

课题名称：帕金森病遗传与环境因素对小胶质细胞的激活及机制

起止时间：2014/01-2018/12

资助经费: 307万元

3)项目来源：国家重点研发计划（2016YFC1306000）子课题

课题名称：遗传、环境、老化因素及其之间的交互作用在帕金森病发生发展机制中的作用

起止时间：2016/01-2020/12

资助经费: 35万元

三）专利

1)发明专利：OMI蛋白及其编码基因的一种新用途ZL 20080239317.5 (授权日2011.7.27)

四）主要荣誉

2004年入选中国科学院“百人计划”

2011年入选江苏省“双创计划”

2014年入选江苏省“双创计划”团队核心成员