应征

应征特聘教授，博士生导师，国家“优秀青年基金”获得者。

Zheng Ying, Ph.D.

zheng.ying@suda.edu.cn

RESEARCH INTERESTS

Increasing evidence indicates thatfurther exploration of cellular quality control system is critical for understanding the basic mechanism underlying neurodegenerative disorders including amyotrophic lateral sclerosis, Parkinson’s disease and Alzheimer’s disease. The goal of our studies is to describe howprotein, organelle andmembrane-less organellequality control systems, including ubiquitin-proteasome system,autophagy andbiomolecular phase separation machinery,fail to protect neuronsat disease stages. To this end,we will use cell biology, molecular biology, biochemical approachesand genetic manipulation of animal models to investigate the relationship between these quality control systems and neurodegeneration.

EDUCATION

2004-2009University of Science and Technology of China

Ph.D. in Neurobiology, November 2009

2000-2004 University of Science and Technology of China

B.S. in Bioscience, July 2004

RESEARCH EXPERIENCES

2016-presentProfessor

Department of Pharmacology, Soochow University College of Pharmaceutical

Sciences

2012-2016Associate Professor

Department of Pharmacology, Soochow University College of Pharmaceutical

Sciences

2010-2012Postdoctoral Research Associate with Dr. Arthur Horwich

Yale University School of Medicine / Howard Hughes Medical Institute (HHMI)

2004-2009Ph.D. Student with Dr. Guanghui Wang

Laboratory of Molecular Neuropathology, Department of Neurobiology, School of Life Sciences , University of Science and Technology of China

SCIENTIFIC TITLE AND AWARD

2020-present“Young Editor” ofActa Pharmaceutica Sinica B

2010Qiu Shi Graduate Student Scholarship by Hong Kong Qiu Shi Science & Technologies Foundation

SELECTED PUBLICATIONS

(¹Co-first author) (*Corresponding author)

1. Wang H¹, Wang N¹, Xu D¹, Ma Q, Chen Y, Xu S, Xia Q, Zhang Y, Prehn JHM,Wang G,Ying Z* (2020). Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.Autophagy. 16(9):1683-1696.

2. Wang M¹, Wang H¹, Tao Z, Xia Q, Hao Z, Prehn JHM, Zhen X, Wang G*,Ying Z*(2020).C9orf72 associates with inactive RRAG GTPases and regulates MTORC1-mediated autophagosomal and lysosomal biogenesis.Aging Cell. 19(4):e13126.

3. Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, Ren H, Chen D, Han J,Ying Z* and Wang G* (2016). TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.EMBO J. 35(2):121-42. Notes: Cover story and highlighted in News & Views in this issue.

4. Xia Q, Wang G*, Wang H, Hu Q,Ying Z* (2016). Folliculin, a tumor suppressor associated with Birt-Hogg-Dube´ (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation.Hum Mol Genet. 25(1):83-96.

5. Tao Z, Wang H, Xia Q, Li K, Li K, Jiang X, Xu G, Wang G*,Ying Z* (2015). Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.Hum Mol Genet. 24(9):2426-41.