姓 名:刘艳丽
职称职务:教授,博士生导师
电子邮箱:liuyanli@suda.edu.cn
办公地址:云轩楼1433
个人简介:
一、学习工作经历
1、学历背景:
1991.9
1995.7沈阳药科大学大学 中药系 本科
1999.9
2002.6沈阳药科大学 药理学 硕士生
2002.9
2005.7沈阳药科大学 药理学 博士生
2、工作经历:
2005.12
2011.6www.优德88.cpm ,讲师
2011.7
2020.6www.优德88.cpm ,副教授
2015.8
2016.8乌普萨拉大学,访问学者
2020.7
至今 www.优德88.cpm ,教授
二、研究方向
(1)结肠炎、银屑病等自身免疫性疾病治疗候选药物分子的发现和机制研究
(2)中药抗炎活性成分新靶点的钩钓、生物学功能验证
三、主要研究成果
发表学术论文100余篇,其中SCI论文50余篇,授权中国专利30余项,转让专利8项。作为课题负责人,承担自然科学基金面上项目1项,新药创制国家重大专项课题子课题1项,苏州市项目1项,校企合作项目8项。自2006年来,对白头翁、鹿茸草、枸骨、毛酸浆、孜然芹等十多种中药进行系统药理活性的研究,发现多种成分的抗炎、抗菌、抗肿瘤等新活性。研究成果发表于Acta Pharmacol. Sin.,Phytother. Res.,J. Ethnopharmacol.,Chin. Med.,Phytomedicine,Phytochemistry,J. Sci. Food Agr.和Brit J. Pharmacol.等期刊。
四、近年来发表的主要论文
Liang QH#, Li QR#, Chen Z, Lv LJ, Lin Y, Jiang HL, Wang KX, Xiao MY, Kang NX, Tu PF, Ji SL, Deng KJ, Gao HW, Zhang L, Li K, Ge F, Xu GQ, Yang SL,Liu YL*, Xu QM*. Anemoside B4, a new pyruvate carboxylase inhibitor, alleviates colitis by reprogramming macrophage function.Inflamm Res. 2024,73(3):345-362.
Qiao Z#, Liao M#, Xiao MY, Luo SY, Wang KX, Niu MX, Jiang HL, Sun SY, Xu GQ, Xu NJ, Xu QM*,Liu YL*. Ephrin B3 exacerbates colitis and colitis-associated colorectal cancer.Biochem Pharmacol. 2024, 220:116004.
Zha Z#, Lin Y#, Wang K, Zhang Y, Li D, Xu G, Xu Q,Liu YL*. Hederacoside C ameliorates colitis via restoring impaired intestinal barrier through moderating S100A9/MAPK and neutrophil recruitment inactivation.Acta Pharmacologica Sinica,2023, 44(1): 105-119.
He L, Liu N, Wang K, Zhang L, Li D, Wang Z, Xu G,Liu YL*,Xu QM*. Rosamultin fromPotentilla anserine L. exhibits nephroprotection and antioxidant activity by regulating the reactive oxygen species/C/EBP homologous protein signaling pathway.Phytother Res, 2021, 35, 6343-6358.
Gao HW, Kang NX, Hu C, Zhang ZY, Xu QM,Liu YL*, Yang SL,Rinsenside Rb1 exerts anti-inflammatory effects in vivo and in vitro by modulating toll like 4 receptor dimerization and NF-kB/MAPKs signaling pathways.Phytomedicine2020, 69: 153197.
He L#, Zhang Y#, Kang NX, Wang YE, Zhang ZY, Zha ZX, Yang SL,Xu QM*,Liu YL*,Anemoside B4 attenuates nephrotoxicity of cisplatin without reducing anti-tumor activity of cisplatin,Phytomedicine2019, 56, 136-146.
Kang NX#, Shen WH#, Zhang Y, Su ZT, Yang SL,Liu YL*,Xu QM*, Anti-inflammatory and immune-modulatory properties of anemoside B4 isolated fromPulsatilla chinensisin vivo,Phytomedicine2019, 64,152934.
Kang NX, Yuan RYK, Huang LT, Liu ZJ, Huang D, Huang L, Gao HW*,Liu YL*,Xu QM, Yang SL.Atypical nitrogen-containing flavonoid in the fruits of Cumin (Cuminum cyminum L.) with anti-inflammatory activity,Journal of agricultural and food chemistry2019, 67, 8339-8347.