应征特聘教授,博士生导师,国家“优秀青年基金”获得者。
Zheng Ying, Ph.D.
RESEARCH INTERESTS
Increasing evidence indicates thatfurther exploration of cellular quality control system is critical for understanding the basic mechanism underlying neurodegenerative disorders including amyotrophic lateral sclerosis, Parkinson’s disease and Alzheimer’s disease. The goal of our studies is to describe howprotein, organelle andmembrane-less organellequality control systems, including ubiquitin-proteasome system,autophagy andbiomolecular phase separation machinery,fail to protect neuronsat disease stages. To this end,we will use cell biology, molecular biology, biochemical approachesand genetic manipulation of animal models to investigate the relationship between these quality control systems and neurodegeneration.
EDUCATION
2004-2009University of Science and Technology of
Ph.D. in Neurobiology, November 2009
2000-2004
B.S. in Bioscience, July 2004
2016-presentProfessor
Department of Pharmacology, Soochow University College of Pharmaceutical
Sciences
2012-2016Associate Professor
Department of Pharmacology,
Sciences
2010-2012Postdoctoral Research Associate with Dr. Arthur Horwich
2004-2009Ph.D. Student with Dr. Guanghui Wang
Laboratory of Molecular Neuropathology, Department of Neurobiology,
SCIENTIFIC TITLE AND AWARD
2020-present“Young Editor” ofActa Pharmaceutica Sinica B
2010Qiu Shi Graduate Student Scholarship by Hong Kong Qiu Shi Science & Technologies Foundation
SELECTED PUBLICATIONS
(1Co-first author) (*Corresponding author)
1. Wang H1, Wang N1, Xu D1, Ma Q, Chen Y, Xu S, Xia Q, Zhang Y, Prehn JHM,Wang G,Ying Z* (2020). Oxidation of multiple MiT/TFE transcription factors links oxidative stress to transcriptional control of autophagy and lysosome biogenesis.Autophagy. 16(9):1683-1696.
2. Wang M1, Wang H1, Tao Z, Xia Q, Hao Z, Prehn JHM, Zhen X, Wang G*,Ying Z*(2020).C9orf72 associates with inactive RRAG GTPases and regulates MTORC1-mediated autophagosomal and lysosomal biogenesis.Aging Cell. 19(4):e13126.
3. Xia Q, Wang H, Hao Z, Fu C, Hu Q, Gao F, Ren H, Chen D, Han J,Ying Z* and Wang G* (2016). TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion.EMBO J. 35(2):121-42. Notes: Cover story and highlighted in News & Views in this issue.
4. Xia Q, Wang G*, Wang H, Hu Q,Ying Z* (2016). Folliculin, a tumor suppressor associated with Birt-Hogg-Dube´ (BHD) syndrome, is a novel modifier of TDP-43 cytoplasmic translocation and aggregation.Hum Mol Genet. 25(1):83-96.
5. Tao Z, Wang H, Xia Q, Li K, Li K, Jiang X, Xu G, Wang G*,Ying Z* (2015). Nucleolar stress and impaired stress granule formation contribute to C9orf72 RAN translation-induced cytotoxicity.Hum Mol Genet. 24(9):2426-41.