周亮

姓名：周亮
职称职务：副研究员、硕士生导师
电子邮箱：liangzhou@suda.edu.cn
办公地址：云轩楼1330

个人简历:

学习经历：

2004.09-2008.07内蒙古大学，本科

2008.09-2013.07中国科学技术大学，博士

研究经历：

2013.10-2016.03美国国立卫生研究院， 博士后

2016.08-至今www.优德88.cpm 助理研究员、副研究员（硕士生导师）

研究方向：

蛋白质降解和修饰

神经相关疾病及组织衰老的分子机制

多发性骨髓瘤细胞Lenalidomide敏感性研究

主要研究成果：
运用分子、细胞、行为学研究神经疾病和多发性骨髓瘤细胞免疫调节药物Lenalidomide敏感性，在Nat. Commun, cell reports,MolecularNeurobiology，Neuroscience等杂志上发表国际期刊论文十余篇。申请国家自然科学基金青年项目等多项科研项目。

科研项目：

1.苏州市科技局项目（医疗卫生应用基础研究）：增强骨髓瘤免疫调节药物敏感性的分子机制研究及临床治疗新策略，2020/07-2023/6。主持。

2.国家自然科学基金青年项目：免疫调节药物结合蛋白cereblon调控p53核质分布及其影响多发性骨髓瘤细胞增殖的机制研究，2018.01-2020.12。主持，已结题。

3.江苏省高等学校自然www.优德88.cpm 面上项目：神经退行性疾病中蛋白聚集体形成的分子机制研究，2017.09-2019.08。主持，已结题。

4.中国博士后科学基金面上资助：泛素连接酶底物受体cereblon调控蛋白聚集体形成的机制，2017.01-2018.12。主持，已结题。

已发表论文：*通讯作者

(1) Wang B^#, Duan J^#,Zhou L*. The paradoxical pharmacological mechanisms of lenalidomide and bortezomib in the treatment of multiple myeloma.Anti-Cancer Drugs32, 227-232 (2021).

(2) Yu W, Wang B,Zhou L*, Xu G*. Endoplasmic reticulum stress-mediated p62 downregulation inhibits apoptosis via c-Jun upregulation.Biomolecules & Therapeutics29, 195-204 (2021). (co-correspondence).

(3)Zhou L*, Duan J. The NMDAR GluN1-1a c-terminus binds to CaM and regulates synaptic function.Biochemical and Biophysical Research Communications534, 323-329 (2021).

(4)Zhou L, Yu W, Jayabalan D, Niesvizky R, Jaffrey S, Huang X*, Xu G*. Caspase-8 inhibition prevents the cleavage and degradation of E3 ligase substrate receptor cereblon and potentiates its biological function.Frontiers in Cell and Developmental Biology(2020),doi: 10.3389/fcell.2020.605989.

(5)Zhou L, Xu G*. Cereblon attenuates DNA damage-induced apoptosis by regulating the transcription-independent function of p53.Cell Death and Disease10, 69 (2019).

(6)Zhou L, Hao Z, Wang G, Xu G*. Cereblon suppresses the formation of pathogenic protein aggregates in a p62-dependent manner.Human Molecular Genetics27, 667-678 (2018).

(7)Zhou L*, Duan J. The c-terminus of NMDAR GluN1-1a subunit translocates to nucleus and regulates synaptic function.Frontiers in Cellular Neuroscience12, (2018), doi:10.3389/fncel.2018.00334.

(8) Chen S, Yang J, Zhang Y, Duan C, Liu Q, Huang Z, Xu Y,Zhou L*, Xu G*. Ubiquitin-conjugating enzyme UBE2O regulates cellular clock function by promoting the degradation of the transcription factor BMAL1.Journal of Biological Chemistry29, 11296-11309 (2018). (co-correspondence,封面论文).

(9)Zhou L^#, Wang H^#, Ren H, Hu Q, Ying Z*, Wang G*. Bcl-2 decreases the affinity of SQSTM1/p62 to poly-ubiquitin chains and suppresses the aggregation of misfolded protein in neurodegenerative disease.MolecularNeurobiology52, 1180-1189 (2015).

(10)Zhou L, Wang H, Chen D, Gao F, Ying Z*, Wang G*. p62/sequestosome 1 regulates aggresome formation of pathogenic ataxin-3 with expanded polyglutamine.International Journal of Molecular Sciences15, 14997-15010 (2014).

(11)Zhou L, Wang H, Ren H, Chen D, Gao F, Hu QS, Fu C, Xu R, Ying Z*, Wang G*. Bcl-2-dependent upregulation of autophagy by sequestosome 1/p62in vitro.Acta Pharmacologica Sinica34, 651-656 (2013).

(12)Zhou L, Wang H, Wang P, Ren H, Chen D, Ying Z*, Wang G*. Ataxin-3 protects cells against H₂O₂-induced oxidative stress by enhancing the interaction between Bcl-X(L) and Bax.Neuroscience243, 14-21 (2013).

(13) Yang J^#, Huang M^#,Zhou L, He X, Jiang X, Zhang Y, Xu G*. Cereblon suppresses the lipopolysaccharide-induced inflammatory response by promoting the ubiquitination and degradation of c-Jun.Journal of Biological Chemistry26, 10141-10157 (2018).

(14) Zhang Y^#, Duan C^#, Yang J, Chen S, Liu Q,Zhou L, Huang Z, Xu Y, Xu G*. Deubiquitinating enzyme USP9X regulates cellular clock function by modulating the ubiquitination and degradation of a core circadian protein BMAL1.Biochemical Journal.8, 1507-1522 (2018).

(15) Chen S, Yang J, Yang L, Zhang Y,Zhou L, Liu Q, Duan C, Mieres CA, Zhou G*, Xu G*. Ubiquitin ligase TRAF2 attenuates the transcriptional activity of the core clock protein BMAL1 and affects the maximal Per1 mRNA level of the circadian clock in cells.The FEBS Journal16, 2987-3001 (2018).

(16) Liu S,Zhou L, Yuan H, Vieira M, Sanz-Clemente A, Badger JD 2nd, Lu W, Traynelis SF, Roche KW*. A rare variant identified within the GluN2B C-terminus in a patient with autism affects NMDA receptor surface expression and spine density.Journal of Neuroscience37, 4093-4102 (2017).

(17) Gu X^#, Mao X^#, Lussier MP^#, Hutchison MA^#,Zhou L, Hamra FK, Roche KW, Lu W*. GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons.Nature Communications7, 10873(2016).

(18) Gu X,Zhou L, Lu W*. An NMDA receptor-dependent mechanism underlies inhibitory synapse development.Cell Reports14, 471-478 (2016).

(19) Wang P, Li B,Zhou L, Fei E, Wang G*. The KDEL receptor induces autophagy to promote the clearance of neurodegenerative disease-related proteins.Neuroscience190, 43-55 (2011).

欢迎广大学生报考！