张熠

发布者：金雪明发布时间：2022-07-07浏览次数：11856

肿瘤分子生物学研究室（Laboratory of Molecular Cancer Research）


Personal Data （个人信息）

Name:    Zhang Yi (Male)张熠（男） 中共党员

Mailing address: Department of Pharmacology （药学院药理学系）

 Medical College of Soochow University （www.优德88.cpm ）

 199 Renai Road, Su Zhou 215123, China （www.优德88.cpm 独墅湖校区云轩楼2315室）

Telephone: 00 86-512-65882090 (Office)

 00 86-512-65208583 (Home)

 00 86-13862167476 (Mobile)

E-mail Address:zhangyi@suda.edu.cn, yzhang25b@gmail.com.

 

Research Interests（研究方向）

 （1）肿瘤的发生和恶化的机制

 （2）抗肿瘤药物耐药性产生机理和信号传导通路变化

 （3）肿瘤治疗新靶点的发现和新药研发

 

EDUCATION （教育经历）

 2007.9-2012.5 Ph.D. of Pharmacology

 Department of Pharmacology & Hershey Medical center, Penn State University

 Medical College of Soochow University

 （博士，药理学专业，www.优德88.cpm -美国宾州州立大学联合培养）

 

 2001.9-2004.7 M.S of Pharmacology

 Department of Pharmacology

 Medical College of Soochow University

 （硕士，药理学专业，www.优德88.cpm ）

 

张熠，博士，2012年获www.优德88.cpm -美国宾州州立大学联合培养药理学博士学位。现为www.优德88.cpm 药理学系教授、博士生导师；www.优德88.cpm 医学部主任助理、www.优德88.cpm 药学院药理学系副主任、www.优德88.cpm -创芯国际类器官药物评价协同创新中心主任。中国药理学会肾脏药理专业委员会委员、BioMed Research International杂志编委、《中华肿瘤防治杂志》青年编委和Frontiers in Pharmacology期刊Guest Editor。

一直从事肿瘤分子生物学、分子药理学和实验治疗学领域的研究探索。对肿瘤发生和恶化机制、抗肿瘤药物耐药性产生机理和信号传导通路的变化、肿瘤治疗新靶点的发现等领域取得了一些创新成果。在Nature Communications、Cancer Res、Oncogene、Autophagy、Theranostics、Cancer Letters和JBC等期刊发表第一/通讯作者论文30余篇。主持省部级以上课题8项，其中国家自然科学基金委项目4项；曾获中美抗癌协会-亚洲癌症研究基金会（USCACA-AFCR）Scholar Award、中国药理学会-施维雅青年药理学家奖、江苏省高校“青蓝工程”优秀青年骨干教师、江苏省“六大人才高峰”高层次人才、获“姑苏科技创业天使计划”资助（2020年）；获江苏省高校自然科学奖二等奖（2018年），江苏医学科技奖三等奖（2020年），江苏省科技进步奖三等奖（2020年）。目前申请中国发明专利4项，已授权1项。

学术任职

  1. 中国药理学会肾脏药理专业委员会委员

  2. BioMed Research International杂志编委

  3. 《中华肿瘤防治杂志》青年编委

  4. Frontiers in Pharmacology: Guest Editor。

  5. www.优德88.cpm -创芯国际类器官药物评价协同创新中心主任

科研项目（负责人）

1、国家自然科学基金面上项目（项目编号：81973352）2020.1-2023.12   55万

  1. 国家自然科学基金面上项目（项目编号：81773749）2018.1-2021.12   48万

3、国家自然科学基金面上项目（项目编号：81473240）2015.1-2018.12   65万

4、江苏省自然科学基金面上项目（项目编号：BK20141197）2014.7-2017.7  10万

5、国家博士后特别资助项目（项目编号：2015T80585）2015.5-2017.5  15万

6、国家博士后基金（一等）资助（项目编号：2014M550308）2014.5-2016.5  8万

7、苏州市应用基础研究∙医疗卫生（SYS201319） 2013.10-2016.10   4万

8、江苏省高校自然科学基金（12KJD310005）2012.9-2015.9  4万

9、江苏省“青蓝工程”优秀青年骨干教师培养，2016.5-2019.5  4万

10、基石药业转化合作资助，2019.7-2021.7  50万

11、江苏省第十六批六大人才高峰资助，2019.9-2022.9  4万

12、www.优德88.cpm -创芯国际类器官药物评价协同创新中心，2020.11-2023.11  100万

13、姑苏科技创业天使计划，2020.7-2022.7  15万

  

科研成果 

  1. ShunLi Dong, Bin Li, ShuMin Yang, FanFan Guo, ZhenYun Li, Lei Peng, Cheng Ji, LingChuan Guo, WeiDong Zhu, ZhiJun Ming, XingCong Ren, JinMing Yang, Yi Zhang*.  Targeting of Tumoral NAC1 Mitigates the Myeloid-derived suppressor cell-mediated immunosuppression and Potentiates Anti-PD-1 Therapy in Ovarian Cancer.  Cancer Immuno Res, (accepted). *(Corresponding author)

  2. Fang Wang, Xuejiao Yu, Jun Qiana, Yumin Cao, Shunli Dong, Shenghua Zhan,Zhen Lue, Robert C. Bast Jr.e, Qingxia Songf, Youguo Chen,*, Yi Zhang**, Jinhua Zhou*.  A Novel SIK2 Inhibitor SIC-19 exhibits Synthetic Lethality with PARP inhibitors in Ovarian Cancer.  Drug Resistance Updates, (In press, Available online 6 March 2024, 101077). **(Corresponding author)

  3. Yixuan Li, Fanfan Guo, Wenjin Wang, FangLin Lv, Lu Zhang, Mingxian Zhu, Shumin Yang Shunli Dong, Mingxuan Zhou, Zhenyun Li, Zengyan, Zhu, Jin-Ming Yang, Yi Zhang*.  Marein, a Novel Natural Product for Restoring Chemo-sensitivity to Cancer Cells through Competitive Inhibition of ABCG2 Function.  Biochemical Pharmacology, (accepted). *(Corresponding author)

  4. ShunLi Dong, XiaoHuiWang, ShuMin Yang, FanFan Guo, JingJing Zhang, ChengJi, LiangRong Shi, Yan Cheng, YanWei Hu, ZhenYun Li, Lei Peng, LingChuan Guo,WeiDong Zhu, Xingcong Ren, Jin-Ming Yang, Yi Zhang*.  Mechanistic insights of NAC1 nuclear export and its role in ovarian cancer resistance to docetaxel.  Biochemical Pharmacology, 2023 May;211:115533. *(Corresponding author)  

  5. Hao-Yan Huanga, Li-Qing Chena, Wei Suna, Huan-Huan Dua, Shunli Donga, Dingyun Caob, Atef Mohammed Qasem Ahmeda, Yi Zhang*, Qing-Ri Cao*. Collagenase IV and clusterin-modified polycaprolactone-polyethylene glycol nanoparticles for penetrating dense tumor tissues.  Theranostics, 2021,11(2):906-924  *(Corresponding author)

  6. Wang Hongyu, Wang Xiaohui, Zhang Yi*, Zhong Zhiyuan*. Systemic Delivery of NAC-1 siRNA by Neuropilin-Targeted Polymersomes Sensitizes Antiangiogenic Therapy of Metastatic Triple Negative Breast Cancer. Biomacromolecules, 2020,21(12):5119-5127  *(Corresponding author)

  7. HuiWen Qian, Juan Li, LiRong Zou, Cheng Ji, HaiYan Li, YuShuang Zheng, LingChuan Guo, WeiDong Zhu, Yi Zhang*.  LTBP1-ALK: A novel fusion identified in malignant pleural effusions from a patient with advanced lung adenocarcinoma.  Lung Cancer, 2020 Jun;144:93-97. *(Corresponding author)

  8. Lingchuan Guo, Weidong Zhu, Xiangyuan Ma, Hao Ni, Enjian Zhong, Yang W.Shao, Jie Yu, Dongmei Gu1, Shundong Ji, , Haodong Xu, Cheng Ji, Jinming Yang*, Yi Zhang*.  Mutations of genes including DNMT3A detected by next-generation sequencing in thyroid cancer. Cancer Biol Ther, 2019,20(3):240-246.  *(Corresponding author)

  9. Xiao-Hui Wang, Cheng Ji, Hong-Han Zhang, Yu Shan, Yi-Jie Ren, Yan-Wei Hu, Ling-Chuan Guo, Wei-Dong Zhu, Yu-Juan Xia1, Bei-Jia Liu, Zi-Yun Rong, Bi-Lian Wu, Zhi-Jun Ming, Jianxun Song, Jin-Ming Yang*, Yi Zhang*.  Identification of a small-molecule compound that inhibits homodimerization of oncogenic NAC1 protein and sensitizes cancer cells to anticancer agents. J Biol Chem, 2019 Jun 21;294(25):10006-10017.  *(Corresponding author)

  10. Yu P, Wang HY, Tian M, Li AX, Chen XS, Wang XL, Zhang Y*, Cheng Y*. Eukaryotic elongation factor-2 kinase regulates the cross-talk between autophagy and pyroptosis in doxorubicin-treated human melanoma cells in vitro. Acta Pharmacol Sin. 2019,Sep;40(9):1237-1244  *(Corresponding author)

  11. Cheng Ji, Qiong-Hua Xu, Ling-Chuan Guo, Yi-Jie Ren, Hong-Han Zhang, Wei-Dong Zhu, Zhi-Jun Ming, Yun-Sheng Yuan, Xin-Cong Ren, Yan Cheng, Jin-Ming Yang*, Yi Zhang*. eEF-2 Kinase-targeted miR-449b Confers Radiation Sensitivity to Cancer Cells, Cancer Lett, 2018, Apr 1;418:64-74.  *(Corresponding author)

  12. Yi Zhang*, Yi-Jie Ren, Ling-Chuan Guo, Cheng Ji, Jian Hu, Hong-Han Zhang,Qiong-Hua Xu, Wei-Dong Zhu, Zhi-Jun Ming, Yun-Sheng Yuan, Xingcong Ren, Jianxun, Song, and Jin-Ming Yang*. Nucleus Accumbens-Associated Protein-1 Promotes Glycolysis and Survival of Hypoxic Tumor Cells via the HDAC4-HIF-1α Axis, Oncogene, 2017 Jul 20;36(29):4171-4181. *(Corresponding author)  Evaluated in“F1000” by“Faculty Of 1000 Biology”

  13. Yi-Jie Ren, Xiao-Hui Wang, Cheng Ji, Yi-Di Guan, Xian-Jiu Lu, Xian-Rong Liu,Hong-Han Zhang, Ling-Chuan Guo, Qiong-Hua Xu, Wei-Dong Zhu, Zhi-Jun Ming, Jin-Ming Yang, Yan Cheng, Yi Zhang*.  Silencing of NAC1 Expression Induces Cancer Cells Oxidative Stress in Hypoxia and Potentiates the Therapeutic Activity of Elesclomol, Front. Pharmacol, 07 November 2017,00804.    

  14. Zhang Y*, Yang WQ, Zhu H, Zhou L, Ren YJ, Ren XC, Zhang L, Wang JR, Liu YB, Yang JM.  Regulation of Autophagy by miR-30d Impacts Sensitivity of Anaplastic Thyroid Carcinoma to Cisplatin,  Biochem Pharmacol,2014 Feb 15;87(4):562-70. *(Corresponding author)      

  15. Ren YJ, Zhang Y*. An update on RNA interference-mediated gene silencing in cancer therapy. Expert Opin Biol Ther, 2014 Nov;14(11):1581-92.  *(Corresponding author) 

  16. Xiao-yuan Liu, Li Zhang, JianPing Wu, Lei Zhou, Yi-Jie Ren, Wei-Qiong Yang, Zi-Jun Ming, Bo Chen, Jianrong Wang, Yi Zhang* and Jin-Ming Yang*.  Inhibition of Elongation Factor-2 Kinase Augments the Antitumor Activity of Temozolomide against Glioma.  PLoS One,2013 Nov 26;8(11):e81345.  *(Corresponding author)    

  17. Zhang Y*, Yang JM*.  Altered energy metabolism in cancer: An unique opportunity for therapeutic intervention.  Cancer Biol Ther,2013 Feb 1; 14(2):81-9. (*Corresponding author)   

  18. Zhang Y, Cheng Y, Ren XC, Hori T, Huber-KeenerKJ, Zhang L, Yap KL, Liu D, Shantz L, Qin ZH, Zhang SP, Wang JR, Wang HG, Shih IM and Yang JM:  Dysfunction of Nucleus Accumbens-1 Activates Cellular Senescence and Inhibits Tumor Cell Proliferation and Oncogenesis.   Cancer Res,72(16): 4262-4275, 2012.    

  19. Zhang Y, Cheng Y, Ren XC, Zhang L, Yap KL, Wu H, Patel R, Liu DX, Qin ZH, Shih IM and Yang JM*:  NAC1 Modulates Sensitivity of Ovarian Cancer Cells to Cisplatin via Altering the HMGB1-Mediated Autophagic Response.  Oncogene, 31(8): 1055-1064, 2012.    

  20. Yang WQ, Zhang Y*.  RNAi-mediated gene silencing in cancer therapy.  Expert Opin Biol Ther, 2012 Nov; 12(11):1495-504. (Invited Review, *Corresponding author)    

  21.  Zhang Y, Jay W. Yang, Xingcong Ren and Jin-Ming Yang. NAC1 and HMGB1 enter a partnership for manipulating autophagy. Autophagy,2011 Dec 1;7(12).  

  22.  Zhang Y*, Cheng Y, Zhang L, Ren X, Huber-Keener KJ, Lee S, Yun J, Wang HG, Yang JM. Inhibition of eEF-2 kinase sensitizes human glioma cells to TRAIL and down-regulates Bcl-xL expression. Biochem Biophys Res Commun,2011 Oct 14; 414(1):129-34. (* Corresponding author)   

  23.  Zhang Y#, Zhang L#, Liu XY, Qin ZH, Yang JM. Expression of elongation factor-2 kinase contributes to anoikis resistance and invasion of human glioma cells. Acta Pharmacol Sin,2011, Mar;32(3):361-7. (# contributed equally to this study)  

  24. Zhang Y*, Yang JM. The impact of cellular senescence in cancer therapy: is it true or not? Acta Pharmacol Sin,2011 Oct; 32(10):1199-207. (* Corresponding author)  

  25. Xi-Sha Chen, Kuan-Song Wang, Wei Guo, Lan-Ya Li, Pian Yu, Xin-Yuan Sun, Hai-Yan Wang, Yi-Di Guan, Yong-Guang Tao, Bo-Ni Ding, Ming-Zhu Yin, Xing-Cong Ren, Yi Zhang, Ce-Shi Chen,Yuan-Chao Ye, Jin-Ming Yang*, and Yan Cheng*. U CH-L1-mediated Down-regulation of Estrogen Receptor α Contributes to Insensitivity to Endocrine Therapy for Breast Cancer.  Theranostics, 2020 Jan 1;10(4):1833-1848.

  26. Liangrong Shi, Junjun Wang, Yi Zhang, Yibei Zhu, Shunli Dong, Xiaohui Wang,Changli Peng, Chunhui Zhou, Ledu Zhou, Xiaodong Li, Hongbing Shi, Wei Wu, Xueyin Long, Changping Wu* & Weihua Liao1,2*.  Inflammation induced by incomplete radiofrequency ablation accelerates tumor progression and hinders PD-1 immunotherapy. Nature Commun, 2019 Nov 28;10(1):5421.

  27. Li Z, Wang Y, Fu C, Wang X, Wang JJ, Zhang Y, Zhou D, Zhao Y, Luo L, Ma H, Lu W, Zheng J, Zhang X.  Design, synthesis, and structure-activity-relationship of a novel series of CXCR4 antagonists. Eur J Med Chem, 2018 Apr 10;149:30-44.

  28. Cheng Y, Ren X, Zhang Y, Shan Y, Huber-Keener KJ, Zhang L, Kimball SR, Harvey H, Jefferson LS, Yang JM.  Integrated regulation of autophagy and apoptosis by EEF2K controls cellular fate and modulates the efficacy of curcumin and velcade against tumor cells. Autophagy, 2013 Feb 1;9(2):208-19. 

  29. Yan Cheng, Ugir Hossain Sk, Yi Zhang, Xingcong Ren, Li Zhang, Kathryn J. Huber-Keener, Yuan-Wan Sun, Jason Liao, Shantu Amin, Arun K. Sharma, and Jin-Ming Yang. Rational incorporation of selenium into temozolomide elicits superior antitumor activity associated with both apoptotic and autophagic cell death. PLoS One, 2012;7(4):e35104.

  30. Cheng Y, Zhang Y, Zhang L, Ren XC, Huber-Keener KJ, Liu XY, Zhou L, Liao J, Keihack H, Yan L, Rubin E, Yang JM. MK-2206, a novel allosteric inhibitor of Akt, synergizes with gefitinib against malignant glioma via modulating both autophagy and apoptosis. Mol Cancer Ther, 2012 Jan;11(1):154-64.  

  31. Cheng Y, Ren X, Zhang Y, Patel R, Sharma A, Wu H, Robertson GP, Yan L, Rubin E, Yang JM. eEF-2 kinase dictates cross-talk between autophagy and apoptosis induced by Akt Inhibition, thereby modulating cytotoxicity of novel Akt inhibitor MK-2206. Cancer Res, 2011 Apr 1;71(7):2654-63.  

  32. Zhang L, Ren XC, Cheng Y, Huber-Keener KJ, Liu XP, Zhang Y, Yuan YS, Yang J, Liu CG, Yang JM: Identification of Sirtuin 3, a Mitochondrial Protein Deacetylase, as a New Contributor to Tamoxifen Resistance in Breast Cancer Cells. Biochem Pharmacol, 86(6): 726-733, 2013.  

  33. Shan Y, Cheng Y, Zhang Y, Guan FQ, Sun H, Ren XC, Chen Y, Feng X, Yang JM: Triticuside A, a Dietary Flavonoid, Inhibits Proliferation of Human Breast Cancer Cells via Inducing Apoptosis. Nutr Cancer, 65(6): 891-899, 2013.

  34. Huber-Keener KJ, Liu X, Wang Z, Wang YQ, Freeman W, Wu S, Planas-Silva MD, Ren XC, Cheng Y, Zhang Y, Vrana K, Liu CG, Yang JM and Wu RL: Differential Gene Expression in Tamoxifen-resistant Breast Cancer Cells Revealed by a New Analytical Model of RNA-Seq Data. PLoS One,7(7): e41333, 2012

  35. Huber-Keener KJ, Evans BR, Ren X, Cheng Y, Zhang Y, Hait WN, Yang JM: Phosphorylation of Elongation Factor-2 Kinase Differentially Regulates the Enzyme's Stability under Stress Conditions. Biochem Biophys Res Commun, 424(2): 308-14, 2012.

    （2）奖项：

    1、江苏省科技进步三等奖，排名第三，2020

    2、江苏医学科技奖三等奖，排名第三，2020

    3、江苏省教育www.优德88.cpm 成果奖（高校自然科学奖），二等奖，2018

    4、江苏省优秀博士论文，2013

    5、中美抗癌协会-亚洲癌症研究基金会（USCACA-AFCR）Scholar Award，2012

    6、中国药理学会-施维雅青年药理学家奖，2014

    （3）授权专利及转化：

    1、小分子化合物的用途及其组合物（CN105726527B），2019年与基石药业签订联合转化合作协议