仇晓琰

姓　　名：仇晓琰

职称职务：特聘副教授

联系电话：0512-65883325

电子邮箱：xqiu@suda.edu.cn

办公地址：云轩楼1325

个人简介：

一、学习工作经历

1、学历背景：

1995.9－1999.6,北京大学，本科学士

1999.9－2001.6, Rensselaer Polytechnic Institute，硕士

2001.9－2007.5,耶鲁大学，博士

2、工作经历：

2007.7－2011.9,宾夕法尼亚大学，医学院生物物理与生化系，博士后

2011.9－2012.10,加州大学旧金山分校，药学院药物化学系，博士后

2013.1－ www.优德88.cpm ，药学院，副教授

二、研究方向

(1)多肽配体的设计和发现

(2)受体信号传导活性的调控

(3)靶向抗癌药物的研发

三、主要研究成果

以多肽结构和活性为研究对象先后在JACS和PNAS等杂志上发表十多篇研究论文。

代表性论文：

1. Li J., Qiu X.J. Quantification of Membrane Protein Self-Association with a High-Throughput Compatible Fluorescence Assay, Biochemistry 2017; 56(14): 1951-1954.

2. Li J., Qiu X. Studies of Conformational Change of The C-Terminal Amphipathic Helix of The Influenza A M2 Protein by FRET, Progress in Biochemistry and Biophysics 2016; 43(8): 796-800.

3. Lanci C.J., MacDermaid C.M., Kang S.G., Acharya R., Noth B., Yang X., Qiu X.J., Degrado W.F., Saven J.G. Computational design of a protein crystal, PNAS 2012; 109(19): 7304-7309.

4. Ghosh A., Qiu J., Degrado W.F., Hochstrasser R.M. Tidal surge in the M2 proton channel sensed by 2D IR spectroscopy, PNAS 2011; 108(15): 6115-6120.

5. Wang J., Qiu J.X., Soto C., Degrado W.F. Structural and dynamic mechanisms for the function and inhibition of the M2 proton channel from influenza A virus, Current Opinion in Structural Biology 2011; 21(1): 68-80. (Review)

6. Tang J., Yin H., Qiu J., Tucker M.J., DeGrado W.F., Gai F. Using two fluorescent probes to dissect the binding, insertion, and dimerization kinetics of a model membrane peptide, J. Am. Chem. Soc. 2009; 131(11): 3816-3817.

7. Goodman J.L., Petersson E.J., Daniels D.S., Qiu J.X., Schepartz A. Biophysical and structural characterization of a robust octameric beta-peptide bundle, J. Am. Chem. Soc. 2007; 129(47): 14746-14751.

8. Petersson E.J., Craig C.J., Daniels D.S., Qiu J.X., and Schepartz A. Biophysical characterization of a beta-peptide bundle: comparison to natural proteins, J. Am. Chem. Soc. 2007; 129(17): 5344-5345.

9. Daniels D.S., Petersson E.J., Qiu J.X., and Schepartz A. High resolution structure of a beta-peptide bundle, J. Am. Chem. Soc. 2007; 129(6): 1532-1533.

10. Qiu J.X., Petersson E.J., Matthews E.E., and Schepartz A. Toward beta-amino acid proteins: a cooperatively folded beta-peptide quaternary structure, J. Am. Chem. Soc. 2006; 128: 11338-11339.

11. Hart S.A., Bahadoor A.B.F., Matthews E.E., Qiu X.J., and Schepartz A. Helix macrodipole control of beta-peptide 14-Helix stability in water, J. Am. Chem. Soc. 2003; 125(14): 4022-4023.