姓名:陈华兵,博士、二级教授、博士生导师
职务荣誉:www.优德88.cpm 药学院副院长
国家自然科学基金杰出青年基金获得者(2021年)
国家自然科学基金优秀青年基金获得者(2014年)
教育部“长江学者奖励计划”青年学者(2016年)
姑苏创新创业领军人才(2022年)
江苏省双创计划人才(2014年)
电子邮箱:chenhb@suda.edu.cn
办公地址:www.优德88.cpm 独墅湖校区二期药学院云轩楼1330
实验室网页:http://pharm-nanomed.suda.edu.cn
一、学习工作经历
1.学历背景
1997.09-2001.07华中科技大学,化学与化工学院,精细化工,本科
2001.09-2004.07华中科技大学,化学与化工学院,无机化学,硕士
2005.09-2008.07华中科技大学,生命科学与技术学院,生物制药工程博士
2.国外学习研究经历
2008.08-2010.12德克萨斯大学西南医学中心(合作导师:高金明教授),博士后
2010.12-2012.02东京大学材料工程系(合作导师:美国工程院外籍院士、
纳米药物研究先驱Kazunori Kataoka教授),博士后
3.工作经历
2012.03-至今www.优德88.cpm 药学院“纳米药物与分子影像”研究室,课题组长
2017.01-2022.10www.优德88.cpm 药学院药剂学系,系主任
2018.09-至今放射医学与辐射防护国家重点实验室,学术带头人
2022.01-至今www.优德88.cpm 药学院,副院长
二、研究方向
1.肿瘤靶向递送系统及创新制剂:聚焦于抗肿瘤药物(如mRNA、免疫药物、化疗药物等)靶向递送及其创新制剂研发,主要通过构建靶向性、智能化的递送系统,增强药物输送效率、调控肿瘤微环境及免疫微环境、探索协同增效新机制等,为高致死、难治性肿瘤如胰腺癌等的高效治疗提供新策略。
2.高性能纳米影像探针:通过靶向递送载体的智能化和功能化设计,实现造影剂对肿瘤的超灵敏、高空间分辨的精准探测,为肿瘤早期发现及手术精准导航提供新手段。
3.新型纳米制剂及临床转化:构建具有临床应用前景的纳米药物载体(如单分子白蛋白纳米粒、胶束、脂质体等),开发高效、低毒的纳米药物新制剂,并与企业合作开展创新制剂产品的临床转化工作。
三、主要教育科研经历与代表性成果
陈华兵,1978年出生,2001年获得华中科技大学精细化工专业本科学位,2008年获得生物制药工程博士学位;2008-2012年在德克萨斯大学西南医学中心、东京大学从事博士后研究;2012年回国任www.优德88.cpm 药学院教授,建立“纳米药物与分子影像”研究室,团队现有教授3人、副教授4人及研究生30余人。2017年任药学院药剂学系主任,2022年1月任药学院副院长,主要负责学院科研工作和药学学科发展。
作为课题负责人,承担了科技部重点研发计划“纳米前沿”重点专项(2023年,课题负责人)、国家自然科学基金杰出青年科学基金(2021年)、优秀青年科学基金(2014年)、面上项目、青年基金、以及江苏省“双创计划”人才(2014年)、姑苏创新创业领军人才计划创新领军人才(2022年)、“苏州市高等院校、科研院所紧缺高层次人才引进资助计划”等十余项国家及省市项目。2016年入选教育部“长江学者奖励计划”青年学者。2021年入选斯坦福大学发布的全球前2%顶尖科学家“年度影响力”榜单(World’s Top 2% Scientists)。作为学术带头人,参与了放射医学与辐射防护国家重点实验室、“双创计划”团队项目、江苏省“特种医学”优势学科、“江苏省重大神经精神疾病诊疗技术研究重点实验室”等国家及省级科研平台的建设。与企业合作,共同开发基于单分子白蛋白载体的创新纳米药物制剂。
迄今为止,发表SCI论文70余篇,其中作为通讯作者在Adv Mater、Nat Commun、ACS Nano、Biomaterials、J Control Release等本领域高水平期刊上发表影响因子大于10的论文30余篇,ESI高被引论文10余篇。参编“十三五”规划教材《药剂学》(科学出版社,副主编)、以及《纳米药物》、《Bioinspired and Biomimetic Systems for Drug and Gene Delivery》、《Advances in Nanotheranostics II: Cancer Theranostic Nanomedicine》等中英文专著3本。获授权中国发明专利10余项、湖北省科技进步二等奖1项。担任《药学学报》、《Nanomaterials》、《Sci China Chem》、《Sci Bull》及《Asian J Pharm Sci》等期刊青年编委或客座编辑。被选为中国药学会纳米药物专业委员会委员、中国抗癌协会纳米肿瘤学专业委员会常务委员等。
在教学方面,承担了国家级一流本科课程《药剂学》(线上一流课程)的建设;负责专业基础课程《药剂学》、《Pharmaceutics》(全英文)和专业前沿课程《纳米技术与生物医药的变革》等本科教学。为研究生讲授《药学研究进展》、《Modern Pharmaceutics》(全英文)、《Modern Pharmaceutics and Drug Discovery》(全英文)等多门课程。
(一)代表性学术论文
72.M Zhang, W Dai, T Yang, T Li, T Xu, Y Deng, H Yang, H Ke*, Y Zhao*,H Chen*. H-shaped miktobrush copolymer nanoassembly facilitates ultrafast nucleus delivery for multi-stimuli-cooperative tumour suppression.Nat Commun,2023, In revision. (IF=17.694)
71.T Li, S Jiang, Y Zhang, J Luo, M Li, H Ke, Y Deng, T Yang*, Xi Sun*,H Chen*. Nanoparticles-mediated TRPV1 channel blockade amplifies cancer thermo-immunotherapy via heat shock factor 1 modulation.Nat Commun,2023, 14, 2498. (IF=17.694)
70.T Li, Y Zhang, J Zhu, F Zhang, Y Li, M Liu, H Ke, T Yang, Y Tang, J Tao, L Miao*, Y Deng*,H Chen*. pH-activatable copper-biomineralized proenzyme for synergistic chemodynamic/ chemo-immunotherapy against aggressive cancers.Adv Mater,2023, 35, 2210201. (IF=32.086)
69.T Li, S Tan, M Li, J Luo, Y Zhang, Z Jiang*, Y Deng, L Han, H Ke, J Shen, Y Tang, F Liu,H Chen*, T Yang*. Holographically activatable nanoprobe via glutathione/albumin-mediated exponential signal amplification for high-contrast tumor imaging.Adv Mater,2023, 35, 2209603. (IF=32.086)
68.Y Zhai, M Liu, T Yang, J Luo, C Wei*, J Shen*, X Song, H Ke, P Sun, M Guo, Y Deng*,H Chen*. Self-activated arsenic manganite nanohybrids for visible and synergistic thermo/ immuno-arsenotherapy.J Control Release,2022, 350, 761-776. (IF=11.467)
67.J Qin, T Yang, J Li, G Zhan, X Li, Z Wei, Z Chen, W Zheng,H Chen*, X Yang*, L Gan*, Bacterial outer membrane vesicle-templated biomimetic nanoparticles for synergistic photothermo-immunotherapy.Nano Today,2022, 46,101591. (IF=18.962)
66.B. Liu, J Jiao, W Xu, M Zhang, P Cui, Z Guo, Y Deng*,H Chen*, W Sun*. Highly Efficient far-red/NIR-absorbing neutral Ir(III) complex micelles for potent photodynamic/photothermal therapy.Adv Mater,2021, 33, 2100795.(IF=32.086)
65.Z Guo, H He, Y Zhang, J Rao, T Yang, T Li, L Wang, M Shi, M Wang, S Qiu, X Song, H Ke, andH Chen*. Heavy-atom-modulated supramolecular assembly increases antitumor potency against malignant breast tumors via tunable cooperativity.Adv Mater,2021, 33, 2004225. (IF=32.086)
64.M He, T Yang, Y Wang, M Wang, X Chen, D Ding*, Y Zheng*,H Chen*. Immune checkpoint inhibitor-based strategies for synergistic cancer therapy.Adv Healthc Mater,2021, 10, 2002104. (IF=11.092)
63.Z Wang, Y Wang, Y Wang, C Wei, Y Deng,H Chen, J Shen*, H Ke*. Biomineralized iron oxide-polydopamine hybrid nanodots for contrast-enhanced T1-weighted magnetic resonance imaging and photothermal tumor ablation.J Mater Chem B,2021,9, 1781-1786.(IF=7.571)
62.H Iqbal, T Yang, T Li, M Zhang, H Ke, D Ding, Y Deng*H Chen*. Serum protein-based nanoparticles for cancer diagnosis and treatment.J Control Release,2021, 329, 997-1022. (IF=11.467)
61.Y Zhang, M Shi, Z Yan, S Zhang, M Wang, H Xu, H Li, Y Ying, S Qiu, J Liu*, H Yang,H Chen, H He*, Z Guo*. Ultrastable near-infrared nonlinear organic chromophore nanoparticles with intramolecular charge transfer for dually photoinduced tumor ablation.Adv Healthc Mater,2020, 9, 2001042. (IF=11.092)
60.Z Yan, M Wang, M Shi, Y He, Y Zhang, S Qiu, H Yang,H Chen, H He*, Z Guo*. Amphiphilic BODIPY dye aggregates in polymeric micelles for wavelength-dependent photo-induced cancer therapy.J Mater Chem B,2020, 8, 6886-6897. (IF=7.571)
59.C Li#, J Wang*, Y Wang#, H Gao#, G Wei#, Y Huang#, H Yu#, Y Gan#, Y Wang#, L Mei#,H Chen#, H Hu#, Z Zhang#, Y Jin#. Recent progress in drug delivery.Acta Pharm Sin B,2019, 9, 1145-1162. (IF=14.903)
58.Q Guo, Q Zhu, T Miao, J Tao, X Ju, Z Sun, H Li, G Xu,H Chen, L Han*. LRP1-upregulated nanoparticles for efficiently conquering the blood-brain barrier and targetedly suppressing multifocal and infiltrative brain metastases.J Control Release,2019, 303, 117-129. (IF=11.467)
57.W Ke, J Li, F Mohammed, Y Wang, K Tou, X Liu, P Wen, H Kinoh, Y Anraku,H Chen, K Kataoka, Z Ge*. Therapeutic polymersome nanoreactors with tumor-specific activable cascade reactions for cooperative cancer therapy.ACS Nano,2019, 13, 2357-2369.(IF=18.027)
56.H Zhao, J Xu, W Huang, G Zhan, Y Zhao*,H Chen*, X Yang*. Spatiotemporally light-activatable platinum nanocomplexes for selective and cooperative cancer therapy.ACS Nano,2019, 13, 6647-6661.(IF=18.027)
55.H Chen#, Z Gu#, H An, C Chen, J Chen, R Cui, S Chen, W Chen, X Chen, X Chen, Z Chen, B Ding, Q Dong, Q Fan, T Fu, D Hou, Q Jiang, H Ke, X Jiang, G Liu, S Li, T Li, Z Liu, G Nie, M Ovais, D Pang, N Qiu, Y Shen, H Tian, C Wang, H Wang, Z Wang, H Xu, J Xu, X Yang, S Zhu, X Zheng, X Zhang, Y Zhao, W Tan*, X Zhang*, Y Zhao*. Precise nanomedicine for intelligent therapy of cancer.Sci China Chem,2018, 61, 1503-1552. (IF=10.138)
54.X Lv, X Wang, T Li, C Wei, Y Tang, T, Yang, Q Wang, X Yang,H Chen, J Shen*, H Yang*, H Ke*. Rationally designed monodisperse Gd2O3/Bi2S3hybrid nanodots for efficient cancer theranostics.Small,2018, 14, 1802904. (IF=15.153)
53.S Ye, J Rao, S Qiu, J Zhao, H He*, Z Yan, T Yang, Y Deng, H Ke, H Yang, Y Zhao, Z Guo*,H Chen*. Rational design of conjugated photosensitizers with controllable photoconversion for dually cooperative phototherapy.Adv Mater,2018, 30, 1801216.(IF=32.086)
52.Y Tang, T Yang, Q Wang, X Lv, X Song, H Ke, Z Guo, X Huang, J Hu, Z Li, P Yang*, X Yang*,H Chen*. Albumin-coordinated assembly of clearable platinum nanodots for photo-induced cancer theranostics.Biomaterials,2018, 154, 248-260. (IF=15.304)
51.Y Wang, Y Deng, H Luo, A Zhu, H Ke, H Yang,H Chen*. Light-responsive nanoparticles for highly efficient cytoplasmic delivery of anticancer agents.ACS Nano,2017, 11, 12134-12144. (IF=18.027)
50.T Yang, H Ke, Q Wang, Y Tang, Y Deng*, H Yang, X Yang, P Yang, D Ling, C Chen, Y Zhao, H Wu*,H Chen*. Bifunctional tellurium nanodots for photo-induced synergistic cancer therapy.ACS Nano,2017, 11, 10012-10024. (IF=18.027)
49.H Luo, Q Wang, Y Deng, T Yang, H Ke, H Yang, H He, Z Guo, D Yu, H Wu,H Chen*. Mutually synergistic nanoparticles for effective thermo-molecularly targeted therapy.Adv Funct Mater,2017, 27, 1702834. (IF=19.924)
48.J Li, K Wei, S Zuo, Y Xu, Z Zha, W Ke,H Chen*, Z Ge*. Light-triggered clustered vesicles with self-supplied oxygen and tissue penetrability for photodynamic therapy against hypoxic tumor.Adv Funct Mater,2017, 27, 1702108. (IF=19.924)
47.R Wen, X Lv, T Yang, Y Li, Y Tang, X Bai, H Ke*, J Shen*,H Chen*. Albumin nanoreactor-templated synthesis of Gd2O3/CuS hybrid nanodots for cancer theranostics.Sci China Mater,2017, 60, 554-562. (IF=8.640)
46.T Yang, L Liu, Y Deng, Z Guo, G Zhang, Z Ge*, H Ke*,H Chen*. Ultrastable near-infrared conjugated polymer nanoparticles for dually photoactive tumor inhibition.Adv Mater,2017, 29, 1700487. (IF=32.086)
45.M Zhang, L Xing, H Ke, Y He, P Cui, Y Zhu, G Jiang, J Qiao, N Lu, HChen*, H Jiang*. MnO2-based nanoplatform serves as drug vehicle and MRI contrast agent for cancer theranostics.ACS Appl Mater Interfaces,2017, 9, 11337-11344. (IF=10.383)
44.H He, S Ji, Y He, A Zhu, Y Zou, Y Deng, H Ke, H Yang, Y Zhao*, Z Guo*,H Chen*. Photoconversion-tunable fluorophore vesicles for wavelength-dependent photo-induced cancer therapy.Adv Mater,2017, 29, 1606690. (IF=32.086)
43.T Yang, Y Tang, L Liu, X Lv, Q Wang, H Ke, Y Deng, H Yang, X Yang, G Liu, Y Zhao,H Chen*. Size-dependent Ag2S nanodots for second near-infrared fluorescence/photoacoustics imaging and simultaneous photothermal therapy.ACS Nano,2017, 11, 1848-1857. (IF=18.027)
42.L Zhou, T Yang, J Wang, Q Wang, X Lv, H Ke, Z Guo, J Shen, Y Wang*, C Xing*,H Chen*. Size-tunable Gd2O3@albumin nanoparticles conjugating Chlorin e6 for magnetic resonance imaging-guided photo-induced therapy.Theranostics,2017, 7, 764-774. (IF=11.600)
41.Y Deng, L Huang, H Yang*, H Ke, H He, Z Guo, T Yang, A Zhu, H. Wu*,H Chen*. Cyanine-anchored silica nanochannels for light-driven synergistic thermo-chemotherapy.Small,2017, 13, 1602747. (IF=15.153)
40.J Li, X He, Y Zou, D Chen, L Yang, J Rao,H Chen, M Chan, L Li, Z Guo, L Zhang*, C Chen. Mitochondria-targeted platinum(II) complexes: dual inhibitory activities on tumor cell proliferation and migration/invasion via intracellular trafficking of beta-catenin.Metallomics,2017, 9, 726-733. (IF=4.636)
39.S Song, H Shen*, T Yang, L Wang, H Fu,H Chen, Z Zhang*. Indocyanine green loaded magnetic carbon nanoparticles for near infrared fluorescence/magnetic resonance dual-modal imaging and photothermal therapy of tumor.ACS Appl Mater Interfaces,2017, 9, 9484-9495. (IF=10.383)
38.Z Guo, Y Zou, H He, J Rao, S Ji, X Cui, H Ke, Y Deng, H Yang, C Chen, Y Zhao,H Chen*. Bifunctional platinated nanoparticles for photo-induced tumor ablation.Adv Mater,2016, 28, 10155-10164. (IF=32.086)
37.T Yang, Y Wang, H Ke, Q Wang, X Lv, H Wu, Y Tang, X Yang, C Chen, Y Zhao,H Chen*. Protein nanoreactor-assisted synthesis of semiconductor nanocrystals for efficient cancer theranostics.Adv Mater,2016, 28, 5923-5930. (IF=32.086)
36.X An, A Zhu, H Luo, H Ke,H Chen*, Y Zhao*. Rational design of multi-stimuli-responsive nanoparticles for precise cancer therapy.ACS Nano,2016, 10, 5947-5958. (IF=18.027)
35.Y Ma, J Huang, S Song,H Chen*, Z Zhang*. Cancer-targeted nanotheranostics: recent advances and perspectives.Small,2016, 12, 4936-4954. (IF=15.153)
34.X Ai, C Ho, J Aw, A Attia, J Mu, Y Wang, X Wang, Y Wang, X Liu,H Chen, M Gao, X Chen, E Yeow, G Liu, M Olivo, B Xing*. In vivo covalent cross-linking of photo-converted rare-earth nanostructures for tumor localization and theranostics.Nat Commun,2016, 7, 10432. (IF=17.694)
33.Y Li, Y Deng, X Tian, H Ke*, M Guo, A Zhu, T Yang, Z Guo, Z Ge, X Yang,H Chen*. Multi-pronged design of light-triggered nanoparticles to overcome cisplatin resistance for efficient ablation of resistant tumor.ACS Nano,2015, 9, 9626-9637. (IF=18.027)
32.A Zhu, K Miao, Y Deng, H Ke, H He, T Yang, M Guo, Y Li, Z Guo, Y Wang, X Yang, Y Zhao*,H Chen*. Dually pH/reduction-responsive vesicles for ultrahigh-contrast fluorescence imaging and thermo-chemotherapy-synergized tumor ablation.ACS Nano,2015, 9,7874-7885. (IF=18.027)
31.Y Wang, T Yang, H Ke, A Zhu, Y Wang, J Wang, J Shen, G Liu, C Chen, Y Zhao,H Chen*. Smart albumin-biomineralized nanocomposites for multimodal imaging and photothermal tumor ablation.Adv Mater,2015, 27, 3874-3882. (IF=32.086)
30.J Huang, M Guo, H Ke, C Zong, B Ren*, G Liu, H Shen, Y Ma, X Wang, H Zhang, Z Deng,H Chen*, Z Zhang*. Rational design and synthesis of γFe2O3@Au magnetic gold nanoflowers for efficient cancer theranostics.Adv Mater,2015, 27, 5049-5056. (IF=32.086)
29.M Guo, J Huang, Y Deng, H Shen, Y Ma, M Zhang, A Zhu, Y Li, H He, Y Wang, X Yang, Z Zhang*,H Chen*. pH-responsive cyanine-grafted graphene oxide for fluorescence resonance energy transfer-enhanced photothermal therapy.Adv Funct Mater,2015, 25, 59-67. (IF=19.924)
28.J Li, Z Lyv, Y Li, H Liu, J Wang, W Zhan, H Chen*,H Chen*, X Li*. A theranostic prodrug delivery system based on Pt(IV) conjugated nano-graphene oxide with synergistic effect to enhance the therapeutic efficacy of Pt drug.Biomaterials,2015, 51, 12-21. (IF=15.304)
27.H Chen#, L Xiao#, Y Anraku, P Mi, X Liu, H Cabral, A Inoue, T Nomoto, A Kishimura*, N Nishiyama*, K Kataoka*. Polyion complex vesicles for photo-induced intracellular delivery of amphiphilic photosensitizer.J Am Chem Soc,2014, 136, 157-163. (IF=16.383)
26.M Guo, H Mao, Y Li, A Zhu, H He, H Yang, Y Wang, X Tian, C Ge, Q Peng, X Wang, X Yang, X Chen, G Liu*,H Chen*. Dual imaging-guided photothermal/photodynamic therapy using micelles.Biomaterials,2014, 35, 4656-4666. (IF=15.304)
25.Z Wan, H Mao, M Guo, Y Li, A Zhu, H Yang, H He, J Shen, L Zhou, Z Jiang, C Ge, X Chen, X Yang, G Liu,H Chen*. Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication.Theranostics,2014, 4, 399-411. (IF=11.600)
24.H Liu, Y Li, Z Lyu, Y Wan, X Li, H Chen,H Chen, X Li*. Enzyme-triggered supramolecular self-assembly of platinum prodrug with enhanced tumor-selective accumulation and reduced systemic toxicity.J Mater Chem B,2014, 2, 8303-8309. (IF=7.571)
23.H Yang, H Mao, Z Wan, A Zhu, M Guo, Y Li, X Li, J Wan, X Yang, X Shuai,H Chen*. Micelles assembled with carbocyanine dyes for theranostic near-infrared fluorescent cancer imaging and photothermal therapy.Biomaterials,2013, 34, 9124-9133. (IF=15.304)
22.G Huang#,H Chen#, Y Dong#, X Luo, H Yu, Z Moore, E Bey, D Boothman*, J Gao*. Superparamagnetic iron oxide nanoparticles: amplifying ROS stress to improve anticancer drug efficacy.Theranostics,2013, 3,116-126. (IF=11.600)
21.H Zhu, J Hao,H Chen, S Jiang, M Liu, H Sun, H Xu, J Zhang, X Yang*. Nanovesicles system for rapid-onset sublingual delivery containing sodium tanshinone IIA sulfonate: In vitro and in vivo evaluation.J Pharm Sci-us,2013, 102,2332-2340. (IF=3.784)
20.H Chen#, H Zhu#, J Hu, Y Zhao, Q Wang, J Wan, Y Yang, H Xu, X Yang*. Highly compressed assembly of deformable nanogels into nanoscale suprastructures and their application in nanomedicine.ACS Nano,2011, 5, 2671-2680. (IF=18.027)
19.H Chen, C Khemtong, X Yang, X Chang, J Gao*. Nanonization strategies for poorly water-soluble drugs.Drug Discov Today,2011, 16, 354-360. (IF=8.369)
18.D Mou,H Chen, J Wan, H Xu, X Yang*. Potent dried drug nanosuspensions for oral bioavailability enhancement of poorly soluble drugs with pH-dependent solubility.Int J Pharm,2011, 413, 237-224. (IF=6.510)
17.W Xiong, W Wang, Y Wang, Y Zhao*,H Chen, H Xu, X Yang. Dual temperature/pH-sensitive drug delivery of poly(N-isopropylacrylamide-co-acrylic acid) nanogels conjugated with doxorubicin for potential application in tumor hyperthermia therapy.Colloids Surf B: Interfaces,2011, 84, 447-453. (IF=5.999)
16.L Xiao, X Xiong, X Sun, Y Zhu, H Yang,H Chen, L Gan*, H Xu, X Yang*. Role of cellular uptake in the reversal of multidrug resistance by PEG-b-PLA polymeric micelles.Biomaterials,2011, 32, 447-453. (IF=15.304)
15.H Chen, L Xiao, D Du, D Mou, H Xu, X Yang*. A facile construction strategy of highly stable nanoparticles for drug delivery using a hydrogel-thickened microemulsion system as a template.Nanotechnology,2010, 21, 5148-5157. (IF=3.953)
14.C Mao, J Wan,H Chen, H Xu, X Yang*. The composition of oil phase modulates venous irritation of lipid emulsion-loaded diallyl trisulfide.Drug Dev Ind Pharm,2010, 36, 698-704. (IF=3.727)
13.E Blanco, E A Bey, C Khemtong, S-G Yang, J Setti-Guthi,H Chen, C W Kessinger, K A Carnevale, W G Bornmann*, D A Boothman, J Gao*. β-Lapachone micellar nanotherapeutics for non-small cell lung cancer therapy.Cancer Res,2010, 70, 3896-3904. (IF=13.312)
12.H Chen, H Zhu, J Zheng, D Mou, J Wan, J Zhang, T Shi, Y Zhao, H Xu, X Yang*. The iontophoresis-driven penetration of lecithin-based nanovesicles through microneedle-induced skin microchannels for transdermal delivery of insulin.J Control Release,2009, 139, 63-72. (IF=11.467)
11.C Mao, J Wan,H Chen, H Xu, X Yang*. Emulsifiers’ composition modulates venous irritation of the nanoemulsions as a lipophilic and venous irritant drug delivery system.AAPS PharmSciTech,2009, 10, 1058. (IF=4.026)
10.H Chen, J Wan, Y Wan, D Mou, H Liu, H Xu, X Yang*. A facile nanoaggregation strategy for oral delivery of hydrophobic drug by utilizing acid-base neutralization reaction.Nanotechnology,2008, 19, 375104. (IF=3.953)
9.L Xu,H Chen, H Xu, X Yang*. Anti-tumour and immuno-modulation effects of triptolide-loaded polymeric micelles.Eur J Pharm Biopharm,2008, 70, 741-748. (IF=5.589)
8.D Mou,H Chen*, D Du, C Mao, J Wan, H Xu, X Yang*. Hydrogel-thickened nanoemulsion system for topical delivery of lipophilic drugs.Int J Pharm,2008, 353, 270-276. (IF=4.026)
7.H Chen, D Mou, D Du, X Chang, D Zhu, J Liu, H Xu, X Yang*. Hydrogel-thickened microemulsion for topical administration of drug molecule at an extremely low concentration.Int J Pharm,2007, 341, 78-84. (IF=4.026)
6.J Liu, W Hu,H Chen, Q Ni, H Xu, X Yang*. Isotretinoin-loaded solid lipid nanoparticles with skin targeting for topical delivery.Int J Pharm,2007, 328, 191-195. (IF=4.026)
5.H Chen, X Chang, D Du, W Liu, J Liu, T Weng, Y Yang, H Xu, X Yang*. Podophyllotoxin-loaded Solid lipid nanoparticles for epidermal targeting.J Control Release,2006, 110, 296-306. (IF=11.467)
4.H Chen, X Chang, D Du, J Li, H Xu, X Yang*. Microemulsion-based hydrogel formulation of ibuprofen for topical delivery.Int J Pharm,2006, 315, 52-58. (IF=4.026)
3.X Chang,H Chen, X Zhao, Z Gao, H Xu, X Yang*. High-performance liquid chromatography determination of triptolide in vitro permeation studies.Anal Chim Acta,2005, 534, 215-221. (IF=6.911)
2.H Chen, X Chang, T Weng, X Zhao, Z Gao, Y Yang, H Xu, X Yang*. A study of microemulsion systems for transdermal delivery of triptolide.J Control Release,2004, 98, 427-436. (IF=11.467)
1.Z Mei,H Chen, T Weng, Y Yang, H Xu, X Yang*. Solid lipid nanoparticle and microemulsion for topical delivery of triptolide.Eur J Pharm Biopharm,2003, 56, 189-196. (IF=5.589)
(二)代表性专著
1.陈华兵等,《药剂学》(科学出版社,副主编),2017年
2. H Ke,H Chen. Chapter 10 - Multimodal Micelles for Theranostic Nanomedicine.Advances in Nanotheranostics II: CancerTheranostic Nanomedicine. Springer-Verlag, Singapore,2016.
3.H Chen, Z Ge, K Kataoka. Chapter 4 - Polymeric Micelles for Cancer-Targeted Drug Delivery.Bioinspired and Biomimetic Systems for Drugand Gene Delivery. Chemical Industry Press and Wiley-VCH Verlag GmbH &Co. KGaA, Germany,2015.
(三)代表性中国发明专利
陈华兵、邓益斌、杨红、柯亨特、刘玲、李厅、杨涛、王璐,一种抗肿瘤铂类药物矿化蛋白纳米粒及其制备方法和应用,ZL201910780919.X。
郭正清、何慧、陈华兵、杨红、饶佳明、史梦柯、王孟雅、应宇辰、张韶,多碘修饰的氟硼二吡咯类衍生物及其制备方法和应用,ZL201910299092.0。
杨红、刘迪、陈华兵、邓安平、吕小燕、王雪、李明、姚枫枫、付佩、徐新早、徐涛,靶向光热治疗联合免疫治疗抗肿瘤复合制剂的制备方法,ZL201910483092.6。
郭正清、饶佳明、何慧、陈华兵、杨红、史梦柯、王孟雅,纳米光敏剂及其制备方法和应用,ZL201811302450.0。
陈华兵、杨红、柯亨特、吕小燕、邓益斌、王雪、杨涛、李明、徐涛,具有近红外光热效应和多模态成像功能的超小蛋白复合纳米粒及其制备方法和应用,ZL201710829251.4。
陈华兵、郭正清、邹烨璘、何慧、邓益斌、柯亨特、杨红、饶佳明,一种铂基化氟硼二吡咯类化合物及制备方法和应用,ZL201610846899.8。
杨红、刘迪、陈华兵、邓安平、吕小燕、王雪、李明、姚枫枫、付佩、徐新早、徐涛,靶向光热治疗联合免疫治疗抗肿瘤复合制剂及其制备方法与应用,ZL201610690276.6。
陈华兵、杨涛、邓益斌、汪勇、柯亨特、郭正清、何慧、杨红、邹烨璘、计双双、汪巧莉,具有近红外光热效应的铜基人血白蛋白纳米复合物及其制备方法,ZL201510566206.5。
陈华兵、邓益斌、杨红、柯亨特、黄丽、朱爱军、郭正清,具有近红外光热和体内荧光成像特点的多功能介孔二氧化硅纳米粒及其制备方法和应用,ZL201510490341.6。
郭正清、陈华兵、邹烨璘、何慧、饶佳明,近红外吸收的光动力活性的铂类化合物、制备方法及其应用,ZL201510622798.8,2017年授权。
杨红、陈华兵、吴秀凤、刘洪月、龚珠萍、顾艳、赵成龙、姚枫枫,一种咪喹莫特泡囊凝胶剂及其制备方法,ZL201310141128.5。
杨红、刘洪月、陈华兵、冒华健、韩楠楠、顾睿南、马雪莹、武艺静,一种叶酸修饰去甲斑蝥素隐形泡囊及其制备方法,ZL201310205438.9。
杨祥良、牟东升、周小顺、万江陵、陈华兵、徐辉碧,一种伊曲康唑纳米结晶及其制备方法和应用,2012.08,CN200910063819.1。
杨祥良、祝红达、陈华兵、徐辉碧、张介眉、郝建军,口腔粘膜给药的小葱提取物纳米乳药物组合物及其制法,2012.09,CN200910273099.1。
陈华兵、杨祥良、徐辉碧、杨亚江、刘卫、周小顺,具有皮肤靶向性的药物组合物及其制备方法和用途,ZL200410013282。
杨祥良,徐辉碧,刘卫,唐琛霞,陈华兵,周小顺,大蒜素注射乳剂及其制备方法,ZL200410060815.5。
(四)代表性国家、省市级科研及人才项目
科技部重点研发计划“纳米前沿”重点专项“工程化细胞微颗粒纳米药物可控制备及其肿瘤治疗新技术”,课题负责人,2023-2027年,614万元
主持姑苏创新创业领军人才计划(创新领军人才)项目“奥沙利铂白蛋白纳米粒的研究与开发”(ZXL2022508),2022-2025年,100万元
主持省科技计划专项资金(重点研发计划社会发展)项目“基于STING激动剂的新型纳米佐剂研究”(BE2022724),2022-2025年,100万元
主持国家自然科学基金杰出青年科学基金项目“生物医用高分子材料”(52125304),2022-2026年,400万元
主持国家自然科学基金面上项目“用于肿瘤光动力/光热协同治疗的低氧依赖性聚合物囊泡研究”(51873143),2019-2022年,59万元
主持国家自然科学基金面上项目“铂类药物蛋白纳米粒的仿生合成及在耐药肿瘤协同治疗中的应用”(31671016),2017-2020年,64万元
主持江苏省高等学校自然www.优德88.cpm 重大项目“铂类药物白蛋白纳米粒的研究”(17KJA350003),2017-2020年,30万元
主持国家自然科学基金优秀青年科学基金项目“药物载体”(31422021),2015-2017年,100万元
主持国家自然科学基金面上项目“用于肿瘤光热/分子靶向双向协同治疗的聚合物胶束研究”(51473109),2015-2018年,83万元
主持江苏省“双创人才”项目,2015-2017年,100万元
主持国家自然科学基金青年科学基金项目“用于肝转移瘤早期探测的可激活近红外荧光纳米探针研究”(81202472),2013-2015年,23万元
主持www.优德88.cpm 东吴学者计划,2016-2020年,50万元
主持“苏州市高等院校、科研院所紧缺高层次人才引进资助计划”,2014-2018年
主持湖北省科技攻关项目“鬼臼毒素微乳凝胶剂的研制”(2005AA301B10),2005-2007年
江苏省“双创计划(团队)”学术骨干,2015-2017年,40万元
四、主要荣誉
1. 2022年姑苏创新创业领军人才计划(创新领军人才)
2. 2021年国家自然科学基金杰出青年科学基金
3.2016年教育部“长江学者奖励计划”青年学者
4. 2016年中国药物制剂大会青年药剂学奖
5. 2014年国家自然科学基金优秀青年科学基金
6. 2014年江苏省“双创计划”人才
7. 2014年苏州市高等院校、科研院所紧缺高层次人才
五、其它
本课题组现招收或联合培养有志从事科研工作的硕、博士研究生及博士后,并欢迎感兴趣的高年级本科生到课题组实习。欢迎具有药学、化学、材料、或生物学背景的同学报考。
联系方式:chenhb@suda.edu.cn
通讯地址:江苏省苏州市苏州工业园区仁爱路199号www.优德88.cpm 药学院云轩楼1330室(邮编:215123)。