姓名:何慧
职称职务:教授
电子邮箱:hhe@suda.edu.cn
办公地址:云轩楼1229
个人简介:
一、学习工作经历
1.学历背景:
1998.09-2002.07江西师范大学化学系,学士
2002.09-2005.09厦门大学化学系,硕士
2007.08-2010.09香港中文大学化学系,博士
2.工作经历:
2005.09-2007.07福建出入境检验检疫局(莆田局),助理工程师
2012.04-2013.08香港中文大学化学系,博士后
2013.08-2020.06www.优德88.cpm 药学院,副教授
2020.07-至今www.优德88.cpm 药学院,教授
二、研究方向
1.光敏药物的设计与合成
2.肿瘤光治疗研究
三、主要研究成果
近年来发表SCI论文二十余篇。主持国家自然科学基金、江苏省自然科学基金、江苏省高校自然科学基金及苏州市民生科技项目共五项。获中国发明专利授权十余项。
1.学术论文:
(1)Li, H.; Xu, H.; Wang, G.; Chen, J.; Ji, D.; Huang, Y.; Cui, G.;He, H.*; Guo, Z.*Rational design of mesoporous coordination polymer nanophotosensitizers for photodynamic tumor ablation.ACS Appl. Mater. Interfaces,2023,15, 21746-21753.
(2)Guo, Z.#;He,H.#;Zhang, Y.#; Rao, J.#; Yang, T.; Li,T.; Wang, L.; Shi, M.; Wang, M.; Qiu, S.; Song, X.; Ke, H.;Chen, H. Heavy-atom-modulated supramolecular assembly increasesantitumor potency against malignant breast tumors via tunable cooperativity.Adv. Mater.2021,33,2004225.
(3)Zhang,Y.; Shi, M.; Yan, Z.; Zhang, S.; Wang, M.; Xu, H.; Li, H.; Ying, Y.; Qiu, S.; Liu, J.*; Yang, H.; Chen, H.;He, H.*; Guo, Z.* Ultrastable near-infrared nonlinear organic chromophorenanoparticles with intramolecular charge transfer fordually photoinduced tumor ablation.Adv. Healthc. Mater.2020,9, 2001042.
(4)Yan, Z.; Wang, M.; Shi, M.; He, Y.; Zhang,Y.; Qiu, S.; Yang, H.; Chen, H.;He, H.*; Guo, Z.* Amphiphilic BODIPY dye aggregates in polymeric micelles for wavelength-dependent photo-induced cancer therapy.J. Mater. Chem. B2020,8,6886-6897.
(5)Ye, S.; Rao, J.; Qiu, S.; Zhao, J.;He, H.*; Yan, Z.; Yang, T.; Deng, Y.; Ke, H.; Yang, H.; Zhao, Y.; Guo, Z.*; Chen, H.* Rational design of conjugated photosensitizers with controllable photoconversion for dually cooperative phototherapy.Adv. Mater.2018,30, 1801216.
(6)He,H.#; Ji, S.#; He, Y.; Zhu, A.; Zou, Y.; Deng, Y.; Ke, H.; Yang, H.; Zhao, Y.; Guo, Z.; Chen, H. Photoconversion-tunable fluorophore vesicles for wavelength-dependent photoinduced cancer therapy.Adv. Mater.2017,29, 1606690.
(7)Guo, Z.#;Zou, Y.#;He,H.#;Rao, J.; Ji, S.; Cui, X.; Ke, H.; Deng, Y.;Yang, H.; Chen, C.; Zhao, Y.; Chen, H.Bifunctional platinated nanoparticles for photoinduced tumor ablation.Adv.Mater.2016,28, 10155-10164.
(8)He, H.; Lo, P.-C.; Ng, D. K. P. A glutathione-activated phthalocyanine-based photosensitizer for photodynamic therapy.Chem. Eur. J.2014,20,6241-6245.
(9)He, H.; Ng, D. K. P. Differential detection of Zn2+and Cd2+ions by BODIPY-based fluorescent sensors.Chem. Asian J.2013,8, 1441-1446.
(10)He, H.; Liu, J.-Y.; Ng, D. K. P.A phthalocyanine-based fluorescent sensor for Zn2+ion.J. Porphyr.Phthalocya.2013,17, 99-103.
(11)He, H.; Lo, P.-C.; Yeung, S.-L.; Fong, W.-P.; Ng, D. K. P. Synthesis andin vitrophotodynamic activities of pegylated distyryl boron dipyrromethene derivatives.J. Med. Chem.2011,54, 3097-3102.
(12)He, H.; Lo, P.-C.; Yeung, S.-L.; Fong, W.-P.; Ng, D. K. P. Preparation of unsymmetrical distyryl BODIPY derivatives and effects of the styryl substituents on theirin vitrophotodynamic properties.Chem. Commun.2011,47, 4748-4750.
(13)He, H.; Ng, D. K. P. A ratiometric near-infrared pH-responsive fluorescent dye based on distyryl BODIPY.Org. Biomol. Chem.2011,9, 2610-2613.
(14)Luo, H.; Wang, Q.; Deng, Y.; Yang, T.; Ke, H.; Yang, H.;He,H.;Guo, Z.; Yu, D.; Wu, H.; Chen, H. Mutually synergistic nanoparticles for effective thermo-molecularly targeted therapy.Adv. Funct. Mater.2017,27, 1702834.
(15)Deng, Y.; Huang, L.; Yang, H.; Ke, H.;He,H.; Guo, Z.; Yang, T.; Zhu, A.; Wu, H.; Chen, H. Cyanine-anchored silica nanochannels for light-driven synergistic thermo-chemotherapy.Small2017,13, 1602747.
(16)Yan, X.; Yu, Y.; Ji, P.;He,H.; Qiao, C. Antitumor activity of endoperoxide-iron chelator conjugates-design, synthesis and biological evaluation.Eur.J. Med. Chem.2015,102, 180-187.
(17)Zhu, A.; Miao, K.; Deng, Y.; Ke, H.;He,H.; Yang, T.; Guo, M.; Li, Y.; Guo, Z.; Wang, Y.; Yang, X.; Zhao, Y.;Chen, H.Dually pH/reduction-responsive vesicles for ultrahigh-contrast fluorescence imaging and thermo-chemotherapy-synergized tumor ablation.ACS Nano2015,9, 7874-7885.
(18)Guo, M.; Huang, J.; Deng, Y.; Shen, H.; Ma, Y.; Zhang, M.; Zhu, A.; Li, Y.;He,H.; Wang, Y.; Yang, X.; Zhang, Z.;Chen, H.pH-responsive cyanine-grafted graphene oxide for fluorescence resonance energy transfer-enhanced photothermal therapy.Adv. Funct. Mater.2015,25, 59-67.
(19)Guo, M.;Mao, H.;Li, Y.;Zhu, A.;He,H.;Yang, H.;Wang, Y.;Tian, X.; Ge, C.; Peng, Q.; Wang, X.;Yang, X.;Chen, X.; Liu, G.;Chen, H.Dual imaging-guided photothermal/photodynamic therapy using micelles.Biomaterials2014,35, 4656-4666.
(20)Wan, Z.; Mao, H.;Guo, M.; Li, Y.;Zhu, A.;Yang, H.;He,H.;Shen, J.; Zhou, L.; Jiang, Z.; Ge, C.; Chen, X.;Yang, X.;Liu, G.;Chen, H.Highly efficient hierarchical micelles integrating photothermal therapy and singlet oxygen-synergized chemotherapy for cancer eradication.Theranostics2014,4, 399-411.
(21)Li, A.;He, H.;Ruan, Y.; Wen, Z.-C.; Zhao, J.-S.; Jiang, Q.-J.; Jiang, Y.-B. Oxidative cyclization of N-acylhydrazones. Development of highly selectiveturn-on fluorescent chemodosimeters for Cu2+.Org. Biomol. Chem.2009,7, 193-200.
(22)Wen, Z.-C.; Yang, R.;He,H.;Jiang, Y.-B. A highly selective charge transfer fluoroionophore for Cu2+.Chem. Commun.2006, 106-108.
(1)国家自然科学基金面上项目,31971298,2020.01-2023.12
(2)苏州市科技计划项目(医疗卫生基础研究),sys2018020,2018.07-021.06
(3)国家自然科学基金青年科学基金项目,81402779,2015.01-2017.12
(4)江苏省自然科学基金青年科学基金项目,BK20140369,2014.07-2017.06
(5)江苏省高校自然科学基金面上项目,14KJB350004,2014.07-2017.06
3.授权专利:
(1)郭正清、李红宇、何慧、徐晗、黄阳阳、纪丹丹,一种非晶态MOF纳米光敏剂及其制备方法与应用,ZL202210409998.5。
(2)郭正清、何慧、徐晗、黄阳阳、纪丹丹、王广林、鲍渴望、崔国庆,一种辣椒素衍生化光敏剂及其制备方法与应用,ZL202210712493.6。
(3)郭正清、纪丹丹、黄阳阳、何慧、徐晗、施江南、赵琳茜、徐嘉婕,一种线粒体靶向光敏剂及其制备方法和应用,ZL202210551017.0。
(4)郭正清、何慧、史梦柯、徐晗、纪丹丹、黄阳阳、何秋瑾,一种近红外纳米光敏剂及其制备方法和应用,ZL202210025998.5
(5)郭正清、黄阳阳、纪丹丹、徐晗、何慧、艾丁丁,一种具有荧光活性的7-乙基-10-羟基喜树碱药物前体及其制备方法和应用,ZL202111455607.5。
(6)郭正清、何慧、王孟雅、史梦柯,一种二氢卟吩纳米光敏剂及其制备方法和应用,ZL202010149420.1
(7)郭正清、何慧、陈华兵、杨红、饶佳明、史梦柯、王孟雅、应宇辰、张韶,多碘修饰的氟硼二吡咯类衍生物及其制备方法和应用,ZL201910299092.0
(8)郭正清、饶佳明、何慧、陈华兵、杨红、史梦柯、王孟雅,纳米光敏剂及其制备方法和应用,ZL201811302450.0
(9)陈华兵、郭正清、邹烨璘、何慧、邓益斌、柯亨特、杨红、饶佳明,一种铂基化氟硼二吡咯类化合物及制备方法和应用,ZL201610846899.8
(10)郭正清、陈华兵、邹烨璘、何慧、饶佳明,具有近红外吸收的光动力学活性的铂类化合物、制备方法及其应用,ZL201510622798.8
(11)陈华兵、杨涛、邓益斌、汪勇、柯亨特、郭正清、何慧、杨红、邹烨璘、计双双、汪巧莉,具有近红外光热效应的铜基人血白蛋白纳米复合物及其制备方法和应用,ZL201510566206.5
四、主要荣誉
1.www.优德88.cpm 建设银行教书育人一等奖,2021年
3.苏州市优秀自然科学论文一等奖,2018年
4.江苏省“双创博士”,2014年
5.苏州市高等院校、科研院所紧缺高层次人才,2014年