郑超湳

姓　　名：郑超湳

职称职务：讲师

电子邮箱：zhengcn@suda.edu.cn

办公地址：云轩楼2109

个人简介：

一、学习工作经历

1、教育背景：

2001.09-2005.07学士药学专业中国药科大学药学基地班

2005.09-2010.07博士药物代谢动力学专业中国药科大学

研究方向：以有效部位为结构单元的生脉方复杂组分代谢处置规律研究。

2.工作经历：

2016.11-至今www.优德88.cpm 药学院，讲师

2013.06-2016.04博士后Albrecht-Kossel神经再生研究所，罗斯托克大学，德国

研究方向：基于NPC1蛋白（Niemann-Pick type C1）结构的

Niemann-Pick罕见病的药物设计与筛选。

2013.02-2013.06博士后罗斯托克蛋白质组学中心，罗斯托克大学，德国

研究方向：计算机模拟KRAB型锌指蛋白与转录中介因子KAP-1

的RBCC结构域的相互作用

2010.08-2011.02高级研究员，药物评价II室(DMPK)，上海医药集团中央研究院。

负责领域：药物的代谢稳定性筛选和代谢物鉴定

二、研究方向

（1）儿童脑肿瘤特异靶点的探寻。

（2）针对儿童脑肿瘤特异靶点的靶向药物设计、筛选和开发。

（3）药物相互作用。

三、主要研究成果

1.科研论文

1. Wang H, Dong Y,Zheng CN,* Sandoval CA, Makha M, Li YH,* Catalytic Cyanation Using CO₂and NH₃,Chem2018Dec;4(12):2883-2893.

2. Bohl C, Pomorski A, Seemann S, Knospe AM,Zheng CN, Krężel A, Rolfs A, Lukas J.,Fluorescent probes for selective protein labeling in lysosomes: a case of α-galactosidase A.FASEB J.2017Dec;31(12):5258-5267.

3. Trilck M, Peter F,Zheng CN, Frank M, Dobrenis K, Mascher H, Rolfs A, Frech M, Diverse manifestation of glycosphingolipid GM2 and cholesterol accumulations in NPC1 patient-specific iPSC-derived neurons carrying different NPC1 mutations.Brain Res.2017 Feb 15;1657:52-61.

4. Lukas J, Pockrandt AM, Seemann S, Sharif M, Runge F, Pohlers S,Zheng CN, Gläser A, Beller M, Rolfs A, Giese AK, Enzyme enhancers for the treatment of fabry and pompe disease.Mol Ther.2015Mar;23(3):456-64.

5. Zheng CN, Hao HP, Wang X, Wu XL, Wang GJ, Sang GW, Liang Y, Xie L, Xia CH, Yao XL, Diagnosticfragment-ion-based extension strategy for rapid screening and identification of serial components of homologous families contained in traditional Chinese medicine prescription using high-resolution LC-ESI-IT-TOF/MS: Shengmai injection as an example.J Mass Spectrom.2009Feb;44(2): 230-44.

6. Zheng CN, Hao HP, Wang GJ, Sang GW, Sun JG, Li P, Li J,Chiral separation of ibuprofen and chiralpharmacokinetics in healthy Chinese volunteers.EurJ Drug Metab Pharmacokinet.2008;33(1): 45-51.

7. Hao HP,Zheng CN, Wang GJ, Thoughts and experimental exploration on pharmacokinetic study of herbal medicines with multiple-components and targets.Acta Pharmaceutica Sinica.200944(3): 270-5.

8. Hao HP, Cui N, Wang GJ, Xiang BR, Liang Y, Xu X, Zhang H, Yang J,Zheng CN, Wu L, Gong P, Wang W,Global detection and identification of nontarget components from herbal preparations by liquidchromatography hybrid ion trap time-of-flight mass spectrometry and a strategy.AnalChem.2008Nov 1;80(21): 8187-94.

9. Hao H, Lai L,Zheng C, Wang Q, Yu G, Zhou X, Wu L, Gong P, Wang G, Microsomal cytochrome p450-mediated metabolism of protopanaxatriol ginsenosides: metabolite profile, reaction phenotyping, and structure-metabolism relationship.Drug Metab Dispos.2010Oct;38(10):1731-9.

10. Lai L, Hao HP, Wang Q,Zheng CN, Zhou F, Liu YT, Wang YX, Yu G, Kang A, Peng Y, Wang GJ, Chen XJ, Effects of Short-term and Long-term Pretreatment of Schisandra Lignans on Regulating Hepatic and Intestinal CYP3A in Rats.Drug Metab Dispos.2009Dec;37(12):2399-407.

11. Lai L, Hao HP, Liu YT,Zheng CN, Wang Q, Wang GJ, Chen XJ,Characterization of pharmacokineticprofiles and metabolic pathways of 20(S)-ginsenoside Rh1 in vivo and in vitro.PlantaMed.2009Jun;75(8):797-802.

2、课题

2019/01-2021/12国家自然科学基金青年基金“胆固醇合成抑制剂协同SMO拮抗剂治疗SHH

型髓母细胞瘤的机制与应用研究”

四、主要荣誉

2008年获得ISSX第二届亚太地区学术会议青年学者奖学金

2013年获得德国莱布尼兹催化研究所奖学金