丁大伟

姓名：丁大伟

职称：特聘教授

电子邮箱：dawei.ding@suda.edu.cn

办公地址：云轩楼2114

个人简介

一、学习工作经历

1、学历背景

2011.8-2015.7新加坡南洋理工大学材料科学与工程，博士

2008.9-2011.6南京大学药剂学，硕士

2004.9-2008.6南京大学生物技术，本科

2.工作经历

2019.6-www.优德88.cpm 药学院，特聘教授

2016.8-2019.6新加坡-麻省理工学院联合研究中心（SMART），博士后

2015.8-2016.6新加坡南洋理工大学，材料科学与工程学院，研究助理/博士后

二、研究方向

1、肿瘤的纳米给药联合治疗系统

2、微针及透皮给药系统

3、眼部及口服给药系统

4、微流控技术及其在生物医学中的应用

三、代表性研究成果

（1）发表论文（*通讯作者）

1. MengyingHe,MengyaoZhang,TaoXu,ShujuanXue,DazhaoLi,YananZhao,FengZhi*,DaweiDing*, Enhancing photodynamic immunotherapy by reprograming the immunosuppressive tumor microenvironment with hypoxia relief.J. Control. Release, 2024, 368, 233-250.(IF=10.8)

2. Kehan Liu, Yao Yao, Shujuan Xue, Mengyao Zhang, Dazhao Li, Tao Xu, Feng Zhi, Yang Liu*, andDawei Ding*, Recent Advances of Tumor Microenvironment-Responsive Nanomedicines-Energized Combined Phototherapy of Cancers.Pharmaceutics2023, 15, 2480.(IF=5.4)

3. Tong Wang, Gang Chen, Shuangshuang Zhang, Dazhao Li, Guanjun Wei, Xiaomei Zhao, Yang Liu*,Dawei Ding*and Xuenong Zhang*, Steerable Microneedles Enabling Deep Delivery of Photosensitizers and CRISPR/Cas9 Systems for Effective Combination Cancer Therapy.Nano Lett.2023,17, 7990-7999.(IF=10.8)

4. Mengyuan Wang, Mengying He, Mengyao Zhang, Shujuan Xue, Tao Xu, Yanan Zhao, Dazhao Li, Feng Zhi,Dawei Ding*, Controllable hypoxia-activated chemotherapy as a dual enhancer for synergistic cancer photodynamic immunotherapy.Biomaterials2023, 301, 122257.(IF=14.0)

5. Mengying He, Mengyuan Wang, Tao Xu, Mengyao Zhang, Huaxing Dai, Chao Wang*,Dawei Ding*, Zhiyuan Zhong*, Reactive oxygen species-powered cancer immunotherapy: Current status and challenges.J. Control. Release2023, 356, 623-648.(ESI高被引论文，IF=10.8)

6. Mengying He, Yuhan Wang, Dazhao Li, Mengyao Zhang, Tong Wang, Feng Zhi*, Xingyue Ji*,Dawei Ding*, Recent applications of phase-change materials in tumor therapy and theranostics.Biomater. Adv.2023, 147, 213309.(IF=7.9)

7. Miao Liu, Yuhan Wang, Zhicheng Yan, Jiabin Yang, Yongyou Wu*,Dawei Ding*, and Xingyue Ji*, Photoclick and Release: Co-activation of Carbon Monoxide and a Fluorescent Self-reporter, COS or Sulfonamide with Fast Kinetics.ChemBioChem2023, 24, e202200506.(IF=3.2)

8. Yuhan Wang, Chunyan Yue, Mengyao Zhang, Dazhao Li, Tao Xu, Mengying He, Mengyuan Wang, Yanan Zhao, Zihui Ni, Feng Zhi, Yiqiao Hu*,Dawei Ding*, Dually enhanced phototherapy by gambogic acid and hyperthemia-activated chemotherapy for synergistic breast cancer treatment.Chem. Eng. J.2023, 452, 139108.(IF=15.1)

9. Tao Xu, Dimitrios Skoulas,Dawei Ding, Sally-Ann Cryan, Andreas Heise*, Exploring the potential of polypeptide–polypeptoide hybrid nanogels for mucosal delivery.Polym. Chem.2022, 13, 6054-6060. (IF=4.6)

10. Xingye Chen, Mengqian Gao, Shan An, Lei Zhao, Wenqing Han, Wenjun Wan, Jin Chen, Siqi Ma, Wenhua Cai, Yanni Cao,Dawei Ding, Yi Yan Yang, Lifang Cheng*, Yiran Zheng*, Enhancing adoptive T cell therapy for solid tumor with cell-surface anchored immune checkpoint inhibitor nanogels.Nanomed.: Nanotechnol. Biol. Med.2022, 45. 102591.(IF=6.5)

11. Lin Ma, Lu Diao, Zuofu Peng, Yun Jia, Huimin Xie, Baisong Li, Jianting Ma, Meng Zhang, Lifang Cheng,Dawei Dinget al., Immunotherapy and Prevention of Cancer by Nanovaccines Loaded with Whole-Cell Components of Tumor Tissues or Cells.Adv. Mater.2021, 33,2170341.(IF=29.4)

12. Mengying He, Tao Yang, Yuhan Wang, Mengyuan Wang, Xinye Chen,Dawei Ding*, Yiran Zheng*, Huabing Chen*, Immune Checkpoint Inhibitor-Based Strategies for Synergistic Cancer Therapy.Adv. Healthcare Mater.2021, 10,2002104.(IF=10.0)

13. Haroon Iqbal, Tao Yang, Ting Li, Miya Zhang, Hengte Ke,Dawei Ding,Yibin Deng* and Huabing Chen*, Serum Protein-Based Nanoparticles for Cancer Diagnosis and Treatment.J. Control. Release, 2021, 329, 997-1022.(IF=10.8)

14. Dawei Dinget al., A Miniaturized Device for Biomembrane Permeation Analysis.Mater. Sci. Eng. C2019, 103, 109772.(IF=7.9)

15. Dawei Dinget al., Design of Mucoadhesive PLGA Microparticles for Ocular Drug Delivery.ACS Appl. Bio Mater.2018, 1, 561−571.(IF=4.7)

16. Dawei Dinget al., Recent Advances of PLGA Micro/nanoparticles for the Delivery of Biomacromolecular Therapeutics.Mater. Sci. Eng. C2018, 92, 1041-1060.(IF=7.9)

17. Dawei Dinget al., Squid Suckerin Microneedle Arrays for Tunable Drug Release.J. Mater. Chem. B2017,5, 8467-8478.(Highlighted on the back cover, IF=7.0)

18. Yuan Ping^#,Dawei Ding^#et al., Supramolecular β-sheets Stabilized Protein Nanocarriers for Drug Delivery and Gene Transfection.ACS Nano2017, 11, 4528-4541. (^#Co-first author,IF=17.1)

19. Dawei Dinget al., From Soft Self-Healing Gels to Stiff Films in Suckerin-Based Materials through Modulation of Crosslink Density and β-Sheet Content.Adv. Mater.2015, 27, 3953-3961.(IF=29.4)

20. Dawei Dinget al., Biomimetic Production of Silk-Like Recombinant Squid Sucker Ring Teeth Proteins.Biomacromolecules2014, 15, 3278−3289.(IF=6.2)

21. Dawei Dinget al., Novel Self-assembly Endows Human Serum Albumin Nanoparticles with an Enhanced Antitumor Efficacy.AAPS PharmSciTech2014, 15, 213-222.(IF=3.3)

22. Victoria Latza, Paul Guerette,Dawei Dinget al., Multi-Scale Thermal Stability of a Hard Thermoplastic Protein-Based Material.Nat. Commun.2015, 6, 8313.(IF=16.6)

23. Bram Cantaert,Dawei Dinget al., Stable Formation of Gold Nanoparticles onto Redox-Active Solid Bio-Substrates Made of Squid Suckerin Proteins.Macromol. Rapid Commun.2015, 36, 1877-1883.(IF=4.6)

24. Paul Guerette, Shawn Hoon,Dawei Dinget al., Nanoconfined β-Sheets Mechanically Reinforce the Supra-Biomolecular Network of Robust Squid Sucker Ring Teeth.ACS Nano2014, 8, 7170-7179.(IF=17.1)

25. Paul Gueretteet al.,Dawei Ding, Ali Miserez, Accelerating the design of biomimetic materials by integrating RNA-seq with proteomics and materials science.Nat. Biotechnol.2013, 31, 908-918.(IF=46.9)

26. Guangming Gong, Feng Zhi, Kaikai Wang, Xiaolei Tang, Ahu Yuan, Lili Zhao,Dawei Dingand Yiqiao Hu, Fabrication of a nanocarrier system through self-assembly of plasma protein and its tumor targeting.Nanotechnology22 (2011) 295603.(IF=3.5)

27. Jinhui Wu,Dawei Dinget al., Sustained delivery of endostatin improves the efficacy of therapy in Lewis lung cancer model.J. Control. Release2009, 134, 91-97.(IF=10.8)

（2）授权专利

1. 丁大伟、赵亚囡、王梦园等，一种连续制备载药纳米乳的方法，中国发明专利ZL 2022 1 0016352.0，已授权。

2. 胡一桥、吴锦慧、丁大伟等，一种用于制备体内递送药理活性物质的蛋白纳米粒的方法，中国发明专利ZL 2010 1 0247885.7，已授权。

3. Yiqiao Hu, Jinhui Wu,Dawei Dinget al., Methods for Drug Delivery Comprising Unfolding and Refolding Proteins and Peptide Nanoparticles，美国发明专利US 9066870 B2，已授权。

4. Yiqiao Hu, Jinhui Wu,Dawei Dinget al., Drug delivery method utilizing unfolding and folding of proteins and peptide nanoparticles，日本发明专利JP 5570599B2，已授权。

5. Yiqiao Hu, Jinhui Wu,Dawei Dinget al., Methods for Drug Delivery Comprising Unfolding and Folding Proteins and Peptide Nanoparticles，欧洲发明专利EP2464224B，已授权。