欧阳艺兰

发布者:金雪明发布时间:2019-07-13浏览次数:4837



名:欧阳艺兰

职称职务:副教授

电子邮箱:y_ouyang@suda.edu.cn

一、学习工作经历

2009.9-2013.7黑龙江大学,本科,制药工程(化学)

2013.9-2016.7www.优德88.cpm ,硕士,药物分析学

2016.9-2019.7www.优德88.cpm ,博士,药物分析学

2018.10-2019.10美国伦斯勒理工博士联合培养

二、研究方向

1.糖胺聚糖等硫酸多糖寡糖的糖组学研究

2.糖药物-免疫学构效关系研究

3.糖类药物的研究与开发

三、主要研究成果

近年来发表的SCI论文

1. Ouyang, Y.; Yi, L.; Qiu, L; Zhang Z.*; Advances in heparin structural analysis by chromatography technologies.Chinese Journal of Chromatography.2023,41(2): 107.

2. Ouyang, Y.; Han, X.; Xia, Q.; Chen, J.; Velagapudi, S.; Xia, K.; Zhang, Z.*; Linhardt, R. J.* Negative-Ion Mode Capillary Isoelectric Focusing Mass Spectrometry for Charge-Based Separation of Acidic Oligosaccharides.Anal. Chem.2019,91(1), 846–853.

3. Ouyang,Y.Zeng, Y.; Rong, Y.; Song, Y.; Shi, L.; Chen, B.; Yang, X.; Xu, N.; Linhardt, R. J.; Zhang, Z. * Profiling Analysis of Low Molecular Weight Heparins by Multiple Heart-Cutting Two-dimensional Chromatography with Quadruple Time-of-Flight Mass Spectrometry.Anal. Chem.2015,87(17): 897-8963.

4. Ouyang, Y.; Yu, Y.; Zhang, F.; Chen, J.; Han, X.; Xia, K.; Yao, Y.; Zhang, Z.*; Linhardt, R. J.* Non-Anticoagulant Low Molecular Weight Heparins for Pharmaceutical Applications.J. Med. Chem.2019,62, 1067-1072.

5. Ouyang, Y.; Zeng, Y.; Yi, L.; Tang, H.; Li, D.; Linhardt, R. J.; Zhang, Z.* Qualitative and Quantitative Analysis of Heparin and Low Molecular Weight Heparins Using Size Exclusion Chromatography with Multiple Angle Laser Scattering/Refractive Index and Inductively Coupled Plasma/Mass Spectrometry Detectors.J. Chromatogr. A2017,1522, 56–61.

6. Ouyang, Y.; Zhu, M.; Wang, X.; Yi, L.; Fareed, J.; Linhardt, R.J.; Zhang, Z.* Systematic Analysis of Enoxaparins from Different Sources with Online One- and Two-dimensional Chromatography.Analyst.2019,144, 3746-3755.

7. Ouyang, Y.; Han, X.; Yu, Y.; Chen, J.; Fu, L.; Zhang, F.; Linhardt, R. J.; Fareed, J.; Hoppensteadt, D.; Jeske, W.; Kouta, A.; Zhang, Z.*; Xia, K.* Chemometric Analysis of Porcine, Bovine and Ovine Heparins.J. Pharm.Biomed. Anal.2019,164, 345-352.

8. Ouyang,Y.;Wu, C.; Sun, X.; Liu, J.; Linhardt, R. J.; Zhang Z.* Development of Hydrophilic-Interaction-Chromatography with Quadruple-Time-of-Flight Mass Spectrometry for Heparin and Low-Molecular-Weight-Heparin Disaccharide Analysis,Rapid Commun. Mass Spectrom.,2016,30: 277-284.

9. Yi, L.;Ouyang,Y.;Sun, X.; Xu, N.; Linhardt, R. J.; Zhang, Z.* Qualitative and Quantitative Analysis of Branches in Dextran using High-Performance Anion Exchange Chromatography coupled to Quadrupole Time-of-Flight Mass Spectrometry,J. Chromatogr.A2015,1423, 79-85.

近五年承担的科研项目

  1. 基于毛细管电泳质谱联用技术(CE-MS)的非抗凝肝素序列解析及其抗炎构效关系研究(82003708),国家自然科学基金青年项目,2021.01-2023.12,主持。

  2. 依诺肝素钠制剂结构确证研究,横向项目,2023.01-2023.1230万,主持。

  3. 肝素类药物糖组学研究(81673388),国家自然科学基金项目(面上),51万,2017.01-2020.12,参与。

  4. 复杂蛋白聚糖的序列分析(81473179),国家自然科学基金项目(面上),80万,2015.01-2018.12,参与。

已申请专利

1. 一种透析在线检测检测装置,CN218567317U

2. 一种部分抗凝肝素衍生物及其制备方法和应用,CN202210176221.9

3. 一种用于低分子量肝素质量分析的二维液相-质谱联用方法,CN202210365757.5

4. β-1,4型葡萄糖醛酸/甘露糖醛酸直链杂合寡糖及其制备方法和应用CN202111010709.6

5. 一种色谱质谱分析用数据处理方法,CN202210008618.7

6. 一种β-14型葡萄糖醛酸/甘露糖醛酸直链杂合寡糖及其制备工艺CN202110284424.5

7. 一种测定肝素类药物重均分子量和含量的方法,CN201710795365.1