姓名:欧阳艺兰
职称职务:副教授
电子邮箱:y_ouyang@suda.edu.cn
一、学习工作经历
2009.9-2013.7黑龙江大学,本科,制药工程(化学)
2013.9-2016.7www.优德88.cpm ,硕士,药物分析学
2016.9-2019.7www.优德88.cpm ,博士,药物分析学
2018.10-2019.10美国伦斯勒理工博士联合培养
二、研究方向
1.糖胺聚糖等硫酸多糖寡糖的糖组学研究
2.糖药物-免疫学构效关系研究
3.糖类药物的研究与开发
三、主要研究成果
近年来发表的SCI论文
1. Ouyang, Y.#; Yi, L.#; Qiu, L; Zhang Z.*; Advances in heparin structural analysis by chromatography technologies.Chinese Journal of Chromatography.2023,41(2): 107.
2. Ouyang, Y.#; Han, X.#; Xia, Q.; Chen, J.; Velagapudi, S.; Xia, K.; Zhang, Z.*; Linhardt, R. J.* Negative-Ion Mode Capillary Isoelectric Focusing Mass Spectrometry for Charge-Based Separation of Acidic Oligosaccharides.Anal. Chem.2019,91(1), 846–853.
3. Ouyang,Y.#Zeng, Y.; Rong, Y.; Song, Y.; Shi, L.; Chen, B.; Yang, X.; Xu, N.; Linhardt, R. J.; Zhang, Z. * Profiling Analysis of Low Molecular Weight Heparins by Multiple Heart-Cutting Two-dimensional Chromatography with Quadruple Time-of-Flight Mass Spectrometry.Anal. Chem.2015,87(17): 897-8963.
4. Ouyang, Y.#; Yu, Y.; Zhang, F.; Chen, J.; Han, X.; Xia, K.; Yao, Y.; Zhang, Z.*; Linhardt, R. J.* Non-Anticoagulant Low Molecular Weight Heparins for Pharmaceutical Applications.J. Med. Chem.2019,62, 1067-1072.
5. Ouyang, Y.#; Zeng, Y.; Yi, L.; Tang, H.; Li, D.; Linhardt, R. J.; Zhang, Z.* Qualitative and Quantitative Analysis of Heparin and Low Molecular Weight Heparins Using Size Exclusion Chromatography with Multiple Angle Laser Scattering/Refractive Index and Inductively Coupled Plasma/Mass Spectrometry Detectors.J. Chromatogr. A2017,1522, 56–61.
6. Ouyang, Y.#; Zhu, M.; Wang, X.; Yi, L.; Fareed, J.; Linhardt, R.J.; Zhang, Z.* Systematic Analysis of Enoxaparins from Different Sources with Online One- and Two-dimensional Chromatography.Analyst.2019,144, 3746-3755.
7. Ouyang, Y.#; Han, X.#; Yu, Y.; Chen, J.; Fu, L.; Zhang, F.; Linhardt, R. J.; Fareed, J.; Hoppensteadt, D.; Jeske, W.; Kouta, A.; Zhang, Z.*; Xia, K.* Chemometric Analysis of Porcine, Bovine and Ovine Heparins.J. Pharm.Biomed. Anal.2019,164, 345-352.
8. Ouyang,Y.#;Wu, C#.; Sun, X.; Liu, J.; Linhardt, R. J.; Zhang Z.* Development of Hydrophilic-Interaction-Chromatography with Quadruple-Time-of-Flight Mass Spectrometry for Heparin and Low-Molecular-Weight-Heparin Disaccharide Analysis,Rapid Commun. Mass Spectrom.,2016,30: 277-284.
9. Yi, L.#;Ouyang,Y.;Sun, X.; Xu, N.; Linhardt, R. J.; Zhang, Z.* Qualitative and Quantitative Analysis of Branches in Dextran using High-Performance Anion Exchange Chromatography coupled to Quadrupole Time-of-Flight Mass Spectrometry,J. Chromatogr.A2015,1423, 79-85.
近五年承担的科研项目
基于毛细管电泳质谱联用技术(CE-MS)的非抗凝肝素序列解析及其抗炎构效关系研究(82003708),国家自然科学基金青年项目,2021.01-2023.12,主持。
依诺肝素钠制剂结构确证研究,横向项目,2023.01-2023.12,30万,主持。
肝素类药物糖组学研究(81673388),国家自然科学基金项目(面上),51万,2017.01-2020.12,参与。
复杂蛋白聚糖的序列分析(81473179),国家自然科学基金项目(面上),80万,2015.01-2018.12,参与。
已申请专利
1. 一种透析在线检测检测装置,CN218567317U
2. 一种部分抗凝肝素衍生物及其制备方法和应用,CN202210176221.9
3. 一种用于低分子量肝素质量分析的二维液相-质谱联用方法,CN202210365757.5
4. β-1,4型葡萄糖醛酸/甘露糖醛酸直链杂合寡糖及其制备方法和应用CN202111010709.6
5. 一种色谱质谱分析用数据处理方法,CN202210008618.7
6. 一种β-1,4型葡萄糖醛酸/甘露糖醛酸直链杂合寡糖及其制备工艺CN202110284424.5
7. 一种测定肝素类药物重均分子量和含量的方法,CN201710795365.1