张海洋

姓 名：张海洋

职 称：副教授

电子邮箱：hyzhang2020@suda.edu.cn

办公地址：云轩楼2103

个人简介：

一、学习工作经历

1、学习经历：

2009.9－2013.7西北大学，应用化学，本科

2013.9－2018.6西北大学，分析化学，博士（硕博连读）

2014.9－2018.6中国科学院大连化学物理研究所，联合培养

2、工作经历：

2018.9－2020.9东南大学，生物科学与医学工程学院，博士后

2020.10－至今www.优德88.cpm 药学院，药物分析系，副教授

二、研究方向

1.外泌体分离方法和癌症标志物的筛选研究

2.外泌体药物递送系统研究

三、项目

1. 国家自然科学基金青年项目，30万元，在研，主持

2. 江苏省高等学校基础科学（自然科学）面上项目，3.0万元，在研，主持

3. 苏州大学“优秀青年学者”启动经费，40万元，在研，主持

4. 中国博士后科学基金第12批特别资助（2019T120373），18.0万元，结题，主持

5. 中国博士后科学基金第65批面上资助（2019M651637），8.0万元，结题，主持

三、主要研究成果

作为第一作者或通讯作者在学科权威期刊Analytical Chemistry、Green Chemistry、Journal of Hazardous Materials、ACS Sustainable Chemistry & Engineering、Biochemical Pharmacology、Analytica Chimica Acta、Journal of Chromatography A等发表论文10余篇，申请专利10项，授权5项。

代表性论文（*通讯作者）

1. Mengxi Chen, Shuang Wang, Qi Zhang, Yawen Zhang, Mengmeng Wang, Xuqing Guo, Yinshuang Chen, Hongjian Zhang, Haiyang Zhang*, Weipeng Wang*, “Facile synthesis of bifunctional metal-organic framework nanoparticles for isolation of extracellular vesicles.”ACS Sustainable Chemistry & Engineering,2022, 10, 7020-7030.

2. Mengmeng Wang, Xuqin Guo, Man Yang, Yawen Zhang, Fanyi Meng, Yinshuang Chen, Mengxi Chen, Tian Qiu, Jiawei Li, Zhi Li, Qi Zhang, Fang Xu, Haiyang Zhang*, Weipeng Wang *. Synergistic antitumor activity of 5-fluorouracil and atosiban against microsatellite stable colorectal cancer through restoring GATA3.Biochem Pharmacol. 2022, 199, 115025.

3. Yinshuang Chen, Man Yang, Fanyi Meng, Yawen Zhang, Mengmeng Wang, Xuqin Guo, Jie Yang, Hongjian Zhang, Haiyang Zhang*, Jing Sun*, Weipeng Wang*. SRSF3 promotes angiogenesis in colorectal cancer by splicing SRF.Front Oncol.2022, 12, 810610.

4. Haiyang Zhang, Yuanyuan Deng, Xinyi Liu, Jie Sun, Leyao Ma, Yajie Ding, Zhen Zhan, Hao Zhang, Yuchen Yang, Yanhong Gu, Anton B Iliuk, Chenxi Yang, W. Andy Tao*, “A glass fiber-supported hybrid monolithic spin tip for enrichment of phosphopeptides from urinary extracellular vesicles”,Anal. Chem.2020, 92, 14790-14797.

5. Haiyang Zhang, Xiaowei Li, Shujuan Ma, Junjie Ou*, Yinmao Wei*, Mingliang Ye, “One-step preparation of phosphate-rich carbonaceous spheres via hydrothermal approach for phosphopeptides analysis”,Green Chem.2019, 21, 2052-2060.

6. Haiyang Zhang, Shujuan Ma, Ya Li, Junjie Ou*, Yinmao Wei*, Mingliang Ye, “Thiol-ene polymerization for hierarchically porous hybrid materials by adding degradable polycaprolactone for adsorption of bisphenol A”,J. Hazard. Maters.2019, 367, 465-472.

7. Haiyang Zhang, Xiaowei Li, Junjie Ou*, Yating Yao, Shujuan Ma, Zhen Liu, Yinmao Wei*, Mingliang Ye*, “Sol-gel Preparation of Titanium (IV)-immobilized Hierarchical Organosilica Hybrid Monoliths”,Anal. Chim. Acta2019, 1046, 199–207.

8. Haiyang Zhang, Junjie Ou*, Yating Yao, Hongwei Wang, Zhongshan Liu, Yinmao Wei*, Mingliang Ye*,“Facile Preparation of Titanium (IV)-immobilized Hierarchically Porous Hybrid Monoliths”Anal. Chem.2017, 89, 4655−4662.

9. Haiyang Zhang, Shujuan Ma, Yating Yao, Yanan Li, Ya Li, Junjie Ou*, Mingliang Ye, Yinmao Wei*,“Facile preparation of multi-functionalized hybrid monoliths via two-step photo-initiated reactions for two-dimensional liquid chromatography-mass spectrometry”J. Chromatogr. A2017, 1524, 135–142.

10. Haiyang Zhang, Junjie Ou*, Yinmao Wei, Hongwei Wang, Zhongshan Liu, Hanfa Zou*,“A hybrid fluorous monolithic capillary column with integrated nanoelectrospray ionization emitter for determination of perfluoroalkyl acids by nano-liquid chromatography-nanoelectrospray ionization-mass spectrometry/mass spectrometry”J. Chromatogr. A2016, 1440, 66–73.

11. Haiyang Zhang, Junjie Ou*, Zhongshan Liu, Hongwei Wang, Yinmao Wei*, Hanfa Zou*,“Preparation of hybrid monolithic columns via “one–pot” photo-initiated thiol-acrylate polymerization for retention-independent performance in capillary liquid chromatography”Anal. Chem.2015, 87, 8789−8797.

12. Haiyang Zhang, Junjie Ou*, Yinmao Wei*, Hongwei Wang, Zhongshan Liu, Lianfang Chen, Hanfa Zou*, “A novel polymeric monolith prepared with multi-acrylate crosslinker forretention-independent efficientseparation of small molecules in capillary liquid chromatography”Anal. Chim. Acta,2015, 883, 90–98.