胡楠

发布者：金雪明发布时间：2022-04-01浏览次数：2386

胡楠

姓名：胡楠

职称职务：副主任药师、硕士生导师

电子邮箱：hn_324@163.com

办公地址：江苏省常州市局前街185号11号楼102

一、个人简介

www.优德88.cpm 药学专业研究生导师；江苏省第五期、第六期“333工程”第三层次培养对象；江苏省青年医学人才培养对象；常州市卫生拔尖人才培养对象；江苏省优秀药师；《中南药学》、《医药导报》杂志青年编委；中国药理学会药物代谢动力学专委会青年委员；中国药理学会治疗药物监测专委会青年委员。

主持国家自然科学基金、江苏省卫健委、江苏省药学会、常州市科技局等各级科研项目十余项，获2020年江苏省医学新技术引进奖二等奖，2021年江苏省药学会奥赛康科研项目二等奖。以第一或通讯作者发表SCI论文15篇，北大核心期刊论文16篇。

二、学习和研究经历

2003/09 - 2007/07，中国药科大学，药学，本科

2007/09 - 2012/07，中国药科大学，药物代谢动力学，硕博连读

2012/10 - 2014/06，澳门大学，中华医药研究院，博士后

2012/08 - 2016/12，常州市第一人民医院，药剂科，主管药师

2017/09 - 2017/12，英国德蒙福特大学，药学院，访问学者

2016/12 -至今，常州市第一人民医院，药剂科，副主任药师

三、研究方向

临床药学，个体化用药，治疗药物监测，药物基因组学，肾移植，糖尿病，肠道菌群

四、代表性论文

  1. Hu Nan, Zhang Qi, Wang Hui, Yang Xuping, Jiang Yan, Chen Rong*, Wang Liying*. Comparative Evaluation of the Effect of Metformin and Insulin on Gut Microbiota and Metabolome Profiles of Type 2 Diabetic Rats Induced by the Combination of Streptozotocin and High-Fat Diet. Front Pharmacol.2022,12: 794103

  2. Xu Shan, Jiang Zhenwei,Hu Nan*.Association between Genetic Polymorphisms and Risk of Kidney Posttransplant Diabetes Mellitus: A Systematic Review and Meta-Analysis.Int J Clin Pract. 2022, publish online

  3. Hu Nan*, Liu Xiang, Mu Qinfeng, Yu Miaomei, Wang Hui, Jiang Yan, Chen Rong, Wang Liying. The gut microbiota contributes to the modulation of intestinal CYP3A1 and P-gp in streptozotocin-induced type 1 diabetic rats. Eur J Pharm Sci. 2021, 162: 105833

  4. Jiang Zhenwei,Hu Nan*. Effect of UGT polymorphisms on pharmacokinetics and adverse reactions of mycophenolic acid in kidney transplant patients .Pharmacogenomics, 2021, 22(15), 1019-1040.

  5. Gu Min, Wang PeiPei, Xiang Shoukui, Xu Dan, Jin Chun, Jiang Zhenwei,Hu Nan*. Effects of type 2 diabetes and metformin on salivary microbiota in patients with chronic periodontitis. Microbial Pathogenesis. Microb Pathog.2021, 161(Pt B):105277

  6. Wei Bin, Wang Yakun, Xiang Shoukui, Jiang Yan, Chen Rong,Hu Nan*. Alterations of gut microbiome in patients with type 2 diabetes mellitus who had undergone cholecystectomy. AJP-Endocrinology and Metabolism. 2021,320(1):E113-E121

  7. Hu Nan, Wang Hui, Qian Qing, Jiang Yan, Zhang Dachuan, Li Qing, Zou Sulan, Chen Rong*.P-glycoprotein with the diabetes mellitus and survival in patients with pancreatic cancer: 8 years follow-up.Brazilian Journal of Medical and Biological Research.2020.53(11): e10168

  8. Ling Jing, Dong Lulu, Yang Xuping, Qian Qin, Jiang Yan, Zou Sulan,Hu Nan*.Effects of CYP3A5, ABCB1 and POR*28 polymorphisms on pharmacokinetics of tacrolimus in the early period after renal transplantation. Xenobiotica. 2020, 50(12):1501-1509

  9. Zhang Qi,Hu Nan*. Effects of metformin on the gut microbiota in obesity and type 2 diabetes mellitus.Diabetes Metab Syndr Obes 2020, 13:5003-5014

  10. Hu Nan, Ling Jing, Dong Lulu, Jiang Yan, Zhou Qi, Zou Sulan.Pharmacokinetics of Omeprazole in Rats With Dextran Sulfate Sodium-Induced Ulcerative Colitis.Drug Metab Pharmacokinet. 2020, 35(3):297-303

  11. Hu Nan, Huang Yanjuan, Gao Xuejiao, Yan Zhixiang, Li Sai, Jing Wanghui, Yan Ru. Effects of dextran sulfate sodium induced experimental colitis on cytochrome P450 activities in rat liver, kidney and intestine. Chem Biol Interact. 2017,1;271:48-58

  12. Huang YJ,Hu Nan(Co-first author),Gao XJ, Yan ZX, Li S, Jing WH, Yan R. Alterations of testosterone metabolism in microsomes from rats with experimental colitis induced by dextran sulfate sodium. Chem Biol Interact, 2015, 232: 38-48

  13. Hu Nan, Hu Mengyue, Duan Ru, Liu Can, Guo Haifang, Zhang Mian, Yu Yunli, Wang Xinting, Liu Li, Liu Xiaodong*. The increased levels of fatty acids contributed to induction of hepatic CYP3A4 activity induced by diabetes. An in vitro evidence from HepG2 cell and Fa2N-4 cell lines. J Pharmacological science, 2014, 124: 433-333

  14. Hu Nan, Mei Mei, Ruan Jianqing, Wu Wenjin, Wang Yitao, Yan Ru*. Regioselective Glucuronidation of Oxyresveratrol, a Natural Hydroxystilbene, by Human Liver and Intestinal Microsomes and Recombinant UGTs. Drug Metab Pharmacokinet. 2014, 29: 229-236

  15. Hu Nan, Xie Shanshan, Liu Li, Wang Xinting, Pan Xian, Chen Guanming, Zhang Lulu, Liu Haiyan, Liu Xiang, Liu Xiaodong*, Xie Lin and Wang Guangji. Opposite Effect of Diabetes Mellitus Induced by Streptozotocin on Oral and Intravenous Pharmacokinetics of Verapamil in Rats. Drug Metab Dispos, 2011, 39: 419-425