• 姓名：姚逸正

• 职称：副教授

• 联系电话： 18952138222

• E-mail： yzyao28@suda.edu.cn

• 研究方向：

  1.新型AAV载体的衣壳工程化改造与筛选

  2.中枢神经系统损伤后神经炎症的调控机制与分子靶向性基因疗法

  3.AAV介导的胶质母细胞瘤的治疗

姚逸正博士，近年来在SCI期刊《Nature Biomedical Engineering》、《Nature Protocols》和《Journal of Controlled Release》等SCI期刊发表论文13篇。同时，也是美国神经科学学会（SfN）和美国细胞与基因治疗协会（ASGCT）的会员。

代表性论文（*第一作者；#通讯作者）:

1.Yao, Y*., Wang, J*., Liu, Y*., Qu, Y*., Wang, K., Zhang, Y., Chang, Y., Yang, Z., Wan, J., Liu, J., Nakashima, H., Lawler, SE., Chiocca, EA., Cho, CF., Bei, F^#. (2022). Variants of the adeno-associated virus serotype 9 with enhanced penetration of the blood-brain barrier in rodents and primates.Nat Biomed Eng6, 1257-1271. 10.1038/s41551-022-00938-7.

2. Wang, K*., Guo, K*., Ji, Z., Liu, Y., Chen, F., Wu, S., Zhang, Q.,Yao, Y^#., and Zhou, Q^#. (2022). Association of Preeclampsia with Incident Dementia and Alzheimer's Disease among Women in the Framingham Offspring Study.J Prev Alzheimers Dis9, 725-730. 10.14283/jpad.2022.62.

3. Chen, W*., Yao, S*., Wan, J*^#., Tian, Y., Huang, L., Wang, S., Akter, F., Wu, Y.,Yao, Y^#., and Zhang, X^#. (2021). BBB-crossing adeno-associated virus vector: An excellent gene delivery tool for CNS disease treatment.J Control Release333, 129-138. 10.1016/j.jconrel.2021.03.029.

4. Bhaskaran, V.,Yao, Y., Bei, F., and Peruzzi, P^#. (2019). Engineering, delivery, and biological validation of artificial microRNA clusters for gene therapy applications.Nat Protoc14, 3538-3553. 10.1038/s41596-019-0241-8.

5.Yao, Y., Shen, Y., Zhu, L., Ni, Y., Wang, H., and Shao, S^#. (2018). Preliminary study and bioinformatics analysis on the potential role of CagQ in type IV secretion system of H.pylori.Microb Pathog116, 1-7.