我组李泽楠在Journal of Environmental Chemical Engineering上发表论文

题目：

Highly efficient photo-driven generation and elimination of reactive oxygen species in biological environment by gold nanoclusters

作者：

Zenan Li,[a] Tianyang Zhang,[a] Jian Shen,[a] YurongMa,[a] Kai Yu,[a] Jiacheng Li,[a]Hui Huang,[a]* Yang Liu,[a]* Zhenhui Kang,[a]*

单位：

[a] Institute of Functional Nano and Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Joint International Research Laboratory of Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, People’s Republic of China.

[b]Macao Institute of Materials Science and Engineering (MIMSE) MUST−SUDA Joint Research Center for Advanced Functional Materials Macau University of Science and Technology Taipa 999078, China.

摘要：

Reactive oxygen species (ROS) play an essential role in cell signalling, pathogen defence, and maintaining cellular homeostasis. The photocatalysts are highly desired in the photo-driven in-situ ROS generation and elimination in biological environment. Here, we present the highly efficient photo-driven generation and elimination of ROS in biological environment by glutathione (GSH)-protected gold nanoclusters (AuNCs). In extracellular environment, AuNCs can generate hydrogen peroxide (H₂O₂) through a two-electron oxygen reduction reaction (ORR) without any additional sacrifices. On the other hand, in intracellular environment, AuNCs are capable of eliminating the ROS in cells under visible light. For the photocatalyst of GSH protected AuNCs, the photogenerated electrons are in response to reduction reactions, and meanwhile photogenerated holes can oxidize the GSH ligands, protecting other biomolecules from oxidation reactions. This work opens a new gate for the concentration manipulation of ROS in the biological environment as well as the real-time regulation of ROS in organisms.

影响因子：

7.7

分区情况：

2区

链接：

https://www.sciencedirect.com/science/article/pii/S2213343723022856