题目：

Nano-Engineered Magnesium Implants for Magnetothermal Enhanced Pyroptosis to Boost Immunotherapy

作者：

Xiao Han^1,4#, Shumin Sun^2#, Nailin Yang^2,3*, Zhihui Han², Zifan Pei², Qiao Yu², Jihu Nie², Li Wang², Anhong Liu^1,4, Xiangxue Meng^1,4, Zhanhui Wang^1,4,5*, and Liang Cheng^2,3*

单位：

¹Luoyang Key Laboratory of Basic and Clinical Application Research of Biomaterials, Luoyang Central Hospital affiliated to Zhengzhou University, Luoyang 471000, China.

²Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China.

³Macao Institute of Materials Science and Engineering, Macau University of Science and Technology, Macau SAR 999078, China.

⁴Henan Provincial Health Commission Key Laboratory of Tumor Nanotechnology, Luoyang Central Hospital affiliated to Zhengzhou University, Luoyang 471000, China.

⁵Henan International Joint Laboratory of Tumor Cell Immunity and Regenerative Medicine, Luoyang Central Hospital affiliated to Zhengzhou University, Luoyang 471000, China.

摘要：

Hepatocellular carcinoma (HCC) is one of the leading contributors to cancer-related death because the immunosuppressive tumor microenvironment (TME) limits its therapeutic efficacy. Gasdermin (GSDM)-mediated pyroptosis is a new programmed cell death that can boost antitumor immune responses. However, inducing efficient pyroptosis to reverse the immunosuppressive TME is challenging. Herein, layered double hydroxide-coated magnesium (Zn-LDH@Mg) implants are designed and constructed as alternating magnetic field (AMF)-activated pyroptosis inducers to induce highly effective pyroptosis in cancer cells. The powerful eddy-thermal effects of Zn-LDH@Mg implants markedly amplify pyroptosis in malignant cells through the Caspase-1/GSDMD-dependent canonical pathway. Moreover, Mg²⁺and pyroptosis synergistically activate T cells (especially CD8⁺T cells) and enhance the infiltration of immune-supportive cells. This innovative strategy not only significantly suppresses the proliferation of the primary tumor but also stimulates the immune response to further enhance the efficacy of immune checkpoint inhibitors and impede the progression of distant tumors. This work not only emphasizes the importance of surface engineering strategies for the preparation of novel pyroptosis inducers but also highlights the effectiveness of the strategy in reversing the immunosuppressive TME to enhance immunotherapy, providing a new approach for the rational design of bioactive materials to increase the efficacy of immunotherapy.

影响因子：

18.5

分区情况：

一区

链接：

https://doi.org/10.1002/adfm.202405836

责任编辑：郭佳