题目：

Fluorinated Titanium Oxide (TiO_2-xF_x) Nanospindles as Ultrasound-Triggered Pyroptosis Inducers to Boost Sonodynamic Immunotherapy

作者：

Shumin Sun¹, Xuan Huang¹, Nailin Yang^1,2*, Huali Lei¹, Zifan Pei¹, Zhihui Han¹, Lin Liu¹, Fei Gong¹, Qiao Yu¹, Jingrui Li¹, Youdong Chen¹, and Liang Cheng^1,2*

单位：

¹Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China.

²Macao Institute of Materials Science and Engineering, Macau University of Science and Technology, Macau SAR 999078, China.

摘要：

Pyroptosis is an inflammatory form of programmed cell death associated with the immune system that can be induced by reactive oxygen species (ROS). As a therapeutic strategy with better penetration depth, sonodynamic therapy (SDT) is expected to induce pyroptosis of cancer cells and boost the immune response. However, it is still a limited problem to precisely adjust the structure of sonosensitizers to exhibit satisfactory sono-catalytic properties. Herein,fluorinated titanium oxide (TiO_2-xF_x) sonosensitizers were developed to induce pyroptosis under ultrasound (US) to boost antitumor immune responses, enabling highly effective SDT. On the one hand, the introduction of F atoms significantly reduced the adsorption energy of TiO_2-xF_xfor oxygen and water, which is conducive to the occurrence of sono-catalytic reactions. On the other hand, the process of F replacing O increased the oxygen vacancies of the sonosensitizer and shortened the band gap, which enabled powerful ROS generation ability under US stimulation. In this case, large amounts of ROS could effectively kill cancer cells by inducing mitochondrial damage and disrupting oxidative homeostasis, leading to significant cell pyroptosis. Moreover, SDT treatment with TiO_2-xF_xnot only suppressed tumor proliferation but also elicited robust immune memory effects and hindered tumor recurrence. This work highlighted the importance of precisely regulating the structure of sonosensitizers to achieve efficient ROS generation for inducing pyroptosis, which sets the stage for further development of SDT-immunotherapy.

影响因子：

15.8

分区情况：

一区

链接：

https://doi.org/10.1021/acsnano.4c05448

责任编辑：郭佳