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程亮教授及其合作者在Matter上发表论文
发布时间:2024-04-25 点击:10

题目:

Self-assembled Silk Fibroin Injectable Hydrogels Based on Layered Double Hydroxides for Spinal Cord Injury Repair

作者:

Xiaoliang Cui1,2#, Li Wang2#, Xiang Gao3#, Jie Wu2, Tian Hu4, Jun Zhang1, Xiaozhong Zhou3*, Ke-Qin Zhang1*, & Liang Cheng2*

单位:

1National Engineering Laboratory for Modern Silk, College of Textile and Clothing Engineering, Soochow University, Suzhou, 215123, China.

2Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215123, P. R. China.

3Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, 215004, China.

4MRC Weatherall Institute of Molecular Medicine, Nuffield Department of Medicine, University of Oxford, Oxford OX3 9DS, UK.

摘要:

Spinal cord injury (SCI) hinders neural regeneration due to the pathological microenvironmentswith reduced Mg2+levels, hypoxia, inflammation, and elevated reactive oxygen species(ROS). Here, we developed a bioactive metal ion-based injectable hydrogel for SCI treatment byintegratingultrathin and antioxidant MgMn-based layered double hydroxides (ULDH) with silk fibroin (SF), which facilitated the formation of ab-sheet structure.SF-ULDH hydrogels continuously scavenge ROS and release oxygen (O2) through Mn3+to alleviate oxidative stress and hypoxia. Impressively, SF-ULDH hydrogels effectively promoted PC12 cell growth and differentiation with the activation of supplemented Mg2+. Bulk RNA sequencing data demonstrated significant enrichment of various pathways, including the PI3K-Akt signaling pathway, HIF-1 signaling pathway, and axon regeneration pathway in the SF-ULDH group. Our findings underscore the importance of combined strategy by integrating bioactive metal ions into hydrogels to address the multifaceted complications of the pathological microenvironment, thereby enhancing SCI repair outcomes.

影响因子:

18.9

分区情况:

一区

链接:

https://doi.org/10.1016/j.matt.2023.11.006



责任编辑:郭佳



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