彭睿
教授博士生导师

1996年获南京大学理学学士学位；1999年获南京大学理学硕士学位；2005年获美国范德比尔特大学（Vanderbilt University）分子生物学博士学位。2008年10月加入www.优德88.cpm 功能纳米与软物质研究院。

研究领域：
纳米生物学，分子生物学，纳米医学

研究方向：
纳米材料的生物学效应与免疫学效应；纳米疫苗；基于纳米材料/生物材料的肿瘤免疫治疗

主要成果和技术贡献：
近年来主要在纳米生物医学材料与纳米医学等领域开展了系统深入的研究，将纳米技术与分子生物学、分子免疫学有机结合，从对纳米生物界面的深入理解出发，研究纳米材料与机体的相互作用机制并对其进行改性与优化。发展了一系列基于高分子与无机矿化材料的活性生物材料作为纳米载体与纳米佐剂用于纳米疫苗、肿瘤纳米诊疗与肿瘤免疫治疗，系统研究了其生物学效应、免疫学效应，揭示了其与肿瘤细胞、免疫细胞及免疫活性生物分子的分子作用机制与相应的信号通路的调控机制，在肿瘤免疫治疗、肿瘤疫苗与细菌疫苗中展现出良好的应用前景。学术论文50余篇，发表于Nature Nanotechnology、ACS Nano、Biomaterials、J. Biol. Chem.等国内外重要学术刊物上，论文他引约6000次。授权国家发明专利2项。主持/参与NSFC、国家重点研发等各级各类项目16项。

近五年代表性论文：

1. Fengyun Shen, Lele Sun*, Lihua Wang,Rui Peng*, Chunhai Fan, and Zhuang Liu*. Framework Nucleic Acid Immune Adjuvant for Transdermal Delivery Based Chemo-immunotherapy for Malignant Melanoma Treatment,Nano Letters, 2022, 22, 4509−4518

2. Qi Zhuang, Jun Xu, Dashi Deng, Ting Chao, Junyan Li, Rui Zhang,Rui Peng*, Zhuang Liu*. Bacteria-derived membrane vesicles to advance targeted photothermal tumor ablation,Biomaterials, 2021, 268, 120550-120563

3. Jun Xu, Jia Lv, Qi Zhuang, Zongjin Yang, Zhiqin Cao, Ligeng Xu, Pei Pei, Chenya Wang, Hanfei Wu, Ziliang Dong, Yu Chao, Chao Wang, Kai Yang,Rui Peng*, Yiyun Cheng* and Zhuang Liu*. A general strategy towards personalized nanovaccines based on fluoropolymers for post-surgical cancer immunotherapy.Nature Nanotechnology, 2020, 15, 1043-1052

4. Fengyun Shen, Liangzhu Feng*, Yujie Zhu, Danlei Tao, Jun Xu,Rui Peng*, Zhuang Liu*. Oxaliplatin-/NLG919 prodrugs-constructed liposomes for effective chemoimmunotherapy of colorectal cancer.Biomaterials, 2020, 255, 120190

5. Chenya Wang§, Yuanpeng Xiao§, Wenwen Zhu, Jiacheng Chu, Jun Xu, He Zhao, Fengyun Shen,Rui Peng*, and Zhuang Liu*. Photosensitizer-Modified MnO2 Nanoparticles to Enhance Photodynamic Treatment of Abscesses and Boost Immune Protection for Treated Mice.Small, 2020, 2000589

6. Jun Xu, Hui Wang, Ligeng Xu, Yu Chao, Chenya Wang, Xiao Han, Ziliang Dong, Hong Chang,Rui Peng*, Yiyun Cheng*, Zhuang Liu*. Nanovaccine based on a protein-delivering dendrimer for effective antigen cross-presentation and cancer immunotherapy,Biomaterials, 2019, 207, 1-9

7. Rong Yang, Jun Xu, Ligeng Xu*, Xiaoqi Sun, Qian Chen, Yuhuan Zhao,Rui Peng*, and Zhuang Liu*. Cancer Cell Membrane-Coated Adjuvant Nanoparticles with Mannose Modification for Effective Anticancer Vaccination.ACS Nano,2018,12, 5121-5129

8. Yonghui Wang, Jun Xu, Ligeng Xu, Xiaofang Tan, Liangzhu Feng, Yinchan Luo, Jian Liu, Zhuang Liu,Rui Peng*. Functionalized graphene oxide triggers cell cycle checkpoint control through both the ATM and the ATR signaling pathways,Carbon, 2018, 129, 495-503

9. Jun Xu, Ligeng Xu,* Chenya Wang, Rong Yang, Qi Zhuang, Xiao Han, Ziliang Dong, Wenwen Zhu,Rui Peng*, and Zhuang Liu*. Near-Infrared-Triggered photodynamic therapy with multi-tasking upconversion nanoparticles in combination with checkpoint blockade for immunotherapy of colorectal cancer.ACS Nano,2017,11, 4463–4474

10. Ligeng Xu, Jian Xiang, Ye Liu, Jun Xu, Yinchan Luo, Liangzhu Feng, Zhuang Liu* andRui Peng*, Functionalized graphene oxide serves as a novel vaccine nano-adjuvant for robust stimulation of cellular immunity.Nanoscale, 2016, 8, 3785 (2016 Hot Articles in Nanoscale)

11. Yinchan Luo, Xinxing Yang, Xiaofang Tan, Ligeng Xu*, Zhuang Liu, Jie Xiao,Rui Peng*, Functionalized graphene oxide in microbial engineering: An effective stimulator for bacterial growth,Carbon, 2016, 13, 172-180

12. Ligeng Xu, Jian Xiang,Rui Peng*, Zhuang Liu.* Recent advances in the development of nanomaterials for DC-based immunotherapy.Sci. Bull., 2016, 61, 514-523

13. Jian Xiang, Ligeng Xu*, Hua Gong, Wenwen Zhu, Chao Wang, Jun Xu, Liangzhu Feng, Liang Cheng,Rui Peng*, and Zhuang Liu*, Antigen-Loaded Upconversion Nanoparticles for Dendritic Cell Stimulation, Tracking, and Vaccination in Dendritic Cell-Based Immunotherapy.ACS Nano,2015,9, 6401–6411

联系电话：0512-65880947

E-mail:rpeng@suda.edu.cn

责任编辑：杨娟