殷黎晨教授博士生导师

2005年7月获复旦大学生物科学专业学士学位；2010年7月获复旦大学生物化学与分子生物学专业博士学位。2010年11月至2014年1月在美国伊利诺伊大学香槟分校（UIUC）材料科学与工程系从事博士后研究工作。2014年1月加盟www.优德88.cpm 功能纳米与软物质研究院，被聘为特聘教授、博士生导师。

邮箱：lcyin@suda.edu.cn

电话：0512-65882039

个人介绍：

国家杰出青年科学基金、优秀青年科学基金获得者，入选江苏省特聘教授（重点资助）、江苏省双创人才、江苏省六大人才高峰。围绕生物医用高分子材料、生物大分子药物递送系统开展研究，发表SCI论文150余篇，其中以通讯作者在Nature Chemical Biology、Nature Communications、Science Advances、PNAS、JACS、Angewandte Chemie、Advanced Materials等知名期刊发表论文80余篇。论文他引9000余次，H因子50。获中国发明专利19项，美国专利2项。为欧美权威教材《Biomaterials Science》、工具书《Encyclopedia of Nanomaterials》等撰写章节。主持国家重点研发计划课题1项、国家自然科学基金7项、江苏省重点研发计划1项。担任美国化学会年会（2019）分会主席、Biomaterial Science期刊副主编、Journal of Controlled Release期刊助理编辑、Advanced Drug Delivery Reviews期刊客座编辑以及多个学术期刊编委/青年编委，任中国抗癌协会医工整合专委会常务委员。

研究方向：

（1）聚氨基酸生物材料：研究可用于药物载体、基因载体、免疫调节剂的聚氨基酸的合成与功能化修饰，探讨聚氨基酸的二级结构效应和调控方式。

（2）智能化药物递送系统：研究可改善蛋白质、多肽、核酸、小分子化学药物、气体分子等功效的新型给药载体的加工、改性、组装、体内外作用机理及其给药系统的设计。

（3）抗炎治疗与抗肿瘤治疗：根据疾病的发病机制及病灶部位的生理特点，设计新型纳米药物调控肿瘤、炎症等免疫微环境，用于肿瘤、炎症（如肝炎、胰腺炎、心肌梗死、急性肺损伤、脑卒中、骨性关节炎等）、自身免疫性疾病（如溃疡性结肠炎、类风湿性关节炎、系统性红斑狼疮等）的治疗。

招生方向：

本课题组热忱欢迎有志从事科研工作的本科生、硕士研究生和博士研究生加盟。本课题组的研究为交叉学科，招生方向包括“化学”、“生物学”以及“材料学”，欢迎具有化学、材料或生物背景的同学报考。如有咨询，请联系lcyin@suda.edu.cn。

招聘信息：

博士后：拟招收3-5名从事高分子生物材料合成、纳米药物设计、基因药物递送研究的博士后研究人员，要求能够独立开展研究工作，具有良好的英文写作与交流能力；易于沟通，可以协助指导研究生。具有高分子化学、有机化学、生物材料或药剂学背景的申请者优先考虑。待遇优厚，且有机会到国外交流访学。如有兴趣，请联系lcyin@suda.edu.cn。

讲师/副教授：拟招聘1-2名课题组讲师/副教授，要求获得（或即将获得）博士学位，具有高分子化学、生物材料或药剂学背景，在主流期刊上发表过SCI论文，能够独立开展研究并指导研究生。有意向者请发送简历和三位推荐人信息至lcyin@suda.edu.cn。

代表性论文（*为通讯作者，^#为共同第一作者）：

1. Xun Liu^#, Ziyin Zhao^#, Wei Li, Ningyu Liu, Qiang Yang,Lichen Yin*. Engineering nucleotidoproteins for base pairing-assisted cytosolic delivery and genome editing.Angew Chem Int Ed, 2023, in press.

2. Chenglong Ge, Junliang Zhu, Huan Ye, Yuansong Wei, Yuheng Lei, Renxiang Zhou, Ziyuan Song,Lichen Yin*. Rational Construction of Protein-mimetic Nano-switch System Based on Secondary Structure Transition of Synthetic Polypeptide.J Am Chem Soc, 2023, 145, 11206-11214.

3. Yang Zhou^#, Qiujun Liang^#, Xuejie Wu, Shanzhou Duan, Chenglong Ge, Huan Ye, Jianhui Lu, Rongying Zhu, Yongbing Chen, Fenghua Meng,Lichen Yin*. siRNA delivery against myocardial ischemia reperfusion injury mediated by reversibly camouflaged biomimetic nanocomplexes.Adv Mater, 2023, 35, 2210691.

4. Yuansong Wei, Xudong Li, Juanhui Lin, Yang Zhou, Jiandong Yang, Mengying Hou, Fan Wu, Jing Yan, Chenglong Ge, Duanmin Hu,Lichen Yin*. Oral delivery of siRNA using fluorinated, small-sized nanocapsules toward anti-inflammation treatment.Adv Mater, 2023, 35, 2206821.

5. Ziyin Zhao^#, Xun Liu^#, Mengying Hou, Renxiang Zhou, Fan Wu, Jing Yan, Wei Li, Yujia Zheng, Qinmeng Zhong,Lichen Yin*. Endocytosis-independent and Cancer-selective Cytosolic Protein DeliveryviaReversible Tagging with LAT1 substrate.Adv Mater, 2022, 34, 2110560.

6. Xun Liu^#, Ziyin Zhao^#, Fan Wu, Yongbing Chen,Lichen Yin*. Tailoring Hyperbranched Poly(β-amino ester) as a Robust and Universal Platform for Cytosolic Protein Delivery.Adv Mater, 2022, 34, 2108116.

7. Mengying Hou, Yuansong Wei, Ziyin Zhao, Wenqing Han, Renxiang Zhou, Yang Zhou, Yiran Zheng,Lichen Yin*. Immuno-Engineered Nanodecoys for the Multi-Target Anti-Inflammatory Treatment of Autoimmune Diseases.Adv Mater, 2022, 34, 2108817.

8. Jing Yan^#, Xun Liu^#, Chenglong Ge, Fan Wu, Huan Ye, Xingye Chen, Yuansong Wei, Renxiang Zhou, Shanzhou Duan, Rongying Zhu, Yiran Zheng,Lichen Yin*. Platelet pharmacytes for the hierarchical amplification of anti-tumor immunity in response to self-generated immune signals.Adv Mater, 2022, 34, 2109517.

9. Yang Zhou^#, Yekun Deng^#, Zhongmin Liu, Mengyuan Yin, Mengyin Hou, Ziyin Zhao, Xiaozhong Zhou,Lichen Yin*. Cytokine-scavenging nanodecoys reconstruct osteoclast/osteoblast balance toward the treatment of postmenopausal osteoporosis.Sci Adv, 2021, 7, eabl6432.

10. Yekun Deng^#, Yang Zhou^#, Qiujun Liang, Chenglong Ge, Jiandong Yang, Bingchen Shan, Yong Liu, Xiaozhong Zhou*,Lichen Yin*. Inflammation-Instructed Hierarchical Delivery of IL-4/miR-21 Orchestrates Osteoimmune Microenvironment Toward the Treatment of Rheumatoid Arthritis.Adv Funct Mater, 2021, 31, 2101033.

11. Jiandong Yang^#, Shanzhou Duan^#, Huan Ye, Chenglong Ge, Chunxian Piao, Yongbing Chen, Minhyung Lee,Lichen Yin*. Pro-peptide-reinforced, mucus-penetrating pulmonary siRNA delivery mitigates cytokine storm in pneumonia.Adv Funct Mater, 2021, 31, 2008960.

12. Yong Liu,Lichen Yin*.α-Amino acidN-carboxyanhydride (NCA)-derived synthetic polypeptides for nucleic acids delivery.Adv Drug Deliver Rev, 2021, 171, 139-163.

13. Xudong Li^#, Yuansong Wei^#, Yuchen Wu,Lichen Yin*. Hypoxia-instructed pro-protein therapy assisted with self-catalyzed nanozymogen.Angew Chem Int Ed, 2020, 59, 22544-22553.

14. Shixian Lv, Hojun Kim, Ziyuan Song, Feng Lin, Yingfeng Yang, Ryan Baumgartner, Kuan-Ying Tseng, Shen J. Dillon, Cecilia Leal,Lichen Yin*, Jianjun Cheng*. Unimolecular polypeptide micelles via ultra-fast polymerization ofN-carboxyanhydrides.J Am Chem Soc, 2020, 142, 8570-8574.

15. Chenglong Ge^#, Jiandong Yang^#, Shanzhou Duan, Yong Liu, Fenghua Meng,Lichen Yin*. Fluorinated α-helical polypeptides synchronize mucus permeation and cell penetration toward highly efficient pulmonary siRNA delivery against acute lung injury.Nano Lett, 2020, 20, 1738−1746.

16. Jing Yan, Qinghua Wu, Ziyin Zhao, Jianhua Wu, Huan Ye, Qiujun Liang, Zhuchao Zhou*, Mengying Hou, Xudong Li, Yong Liu*,Lichen Yin*. Light-assisted hierarchical intratumoral penetration and programmed antitumor therapy based on tumor microenvironment (TME)-amendatory and self-adaptive polymeric nanoclusters.Biomaterials, 2020, 255, 120166.

17. Yongjuan Li, Juanjuan Dang, Qiujun Liang,Lichen Yin*. Thermal-responsive carbon monoxide (CO) delivery expedites metabolic exhaustion of cancer cells toward reversal of chemotherapy resistance.ACS Cent Sci, 2019, 5, 1044−1058.

18. Yongjuan Li^#, Juanjuan Dang^#, Qiujun Liang,Lichen Yin*. Carbon monoxide (CO)-strengthened cooperative bioreductive anti-tumor therapy via mitochondrial exhaustion and hypoxia induction.Biomaterials, 2019, 209, 138-151.

19. Juanjuan Dang, Huan Ye, Yongjuan Li, Qiujun Liang, Xudong Li,Lichen Yin*. Multivalency-assisted membrane-penetrating siRNA delivery sensitizes photothermal ablation via inhibition of tumor glycolysis metabolism.Biomaterials, 2019, 223, 119463.

20. Jinhui Wang^#, Hua He^#, Xin Xu, Xiao Wang, Yongbing Chen,Lichen Yin*. Far-Red Light-Mediated Programmable Anti-Cancer Gene Delivery in Cooperation with Photodynamic Therapy.Biomaterials, 2018, 171, 72-82.

21. Shixian Lv, Yuchen Wu, Kaimin Cai, Hua He, Yongjuan Li,Min Lan, Xuesi Chen, Jianjun Cheng,Lichen Yin*. High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor−Receptor Coordination Interactions.J Am Chem Soc, 2018, 140, 1235−1238.

22. Hong-Xia Wang, Ziyuan Song, Yeh-Hsing Lao, Xin Xu, Jing Gong, Du Cheng, Syandan Chakraborty, Mingqiang Li, Dangtong Huang,Lichen Yin*, Jianjun Cheng*, Kam W. Leong*. Nonviral Gene Editing via CRISPR/Cas9 Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide.Proc Natl Acad Sci USA, 2018, 115, 4903-4908.

23. Hua He^#, Yongbing Chen^#, Yongjuan Li^#, Ziyuan Song, Yinan Zhong, Rongying Zhu, Jianjun Cheng*,Lichen Yin*. Effective and Selective Anti-Cancer Protein Delivery via All-Function-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering.Adv Funct Mater,2018, 28, 1706710.

24. Hua Wang^#, Ruibo Wang^#, Kaimin Cai^#, Hua He, Yang Liu, Jonathan Yen, Zhiyu Wang, Ming Xu, Yiwen Sun, Xin Zhou, Qian Yin, Li Tang, Iwona T Dobrucki, Lawrence W Dobrucki, Eric J Chaney, Stephen A Boppart, Timothy M Fan, Stéphane Lezmi, Xuesi Chen*,Lichen Yin*, Jianjun Cheng*. Selective in vivo metabolic cell-labeling-mediated cancer targeting.Nat Chem Biol, 2017, 13, 415-424.

25. Ziyuan Song, Rachael A. Mansbach, Hua He, Kuo-Chih Shih, Ryan Baumgartner, Nan Zheng, Xiaochu Ba, Yinzhao Huang, Deepak Mani, Yun Liu, Yao Lin, Mu-Ping Nieh, Andrew L. Ferguson*,Lichen Yin*, Jianjun Cheng*. Modulation of polypeptide conformation through donor–acceptor transformation of side-chain hydrogen bonding ligands.Nat Commun, 2017, 8:92.

26. Menghua Xiong^#, Yan Bao^#, Xin Xu^#, Hua Wang, Zhiyuan Han, Zhiyu Wang, Yeqing Liu, Songyin Huang, Ziyuan Song, Jinjing Chen, Richard M. Peek,Lichen Yin*, Lin-Feng Chen*, Jianjun Cheng*. Selective killing of Helicobacter pylori with pH-responsive helix–coil conformation transitionable antimicrobial polypeptides.Proc Natl Acad Sci USA, 2017, 114, 12675-12680.

27. Menghua Xiong, Zhiyuan Han, Ziyuan Song, Jin Yu, Hanze Ying,Lichen Yin*, Jianjun Cheng*. Bacteria-Assisted Activation of Antimicrobial Polypeptides by a Random-Coil to Helix Transition.Angew Chem Int Ed,2017, 56, 10826-10829.

文章完整列表：https://scholar.google.com/citations?user=66CEhX8AAAAJ&hl=zh-CN

责任编辑：杨娟