报告题目：Mechanism of inner ear development.

报告人:刘东研究员

报告时间: 2010 年10 月11 日 下午3:00PM

报告地点:www.优德88.cpm 独墅湖校区炳麟图书馆825会议室

报告人简介：刘东,男，博士，北京大学生命科学院和生物膜及膜生物工程国家重点实验室研究员（Principle investigator），博士生导师。刘东研究员在中科院武汉水生生物研究所朱作言院士指导下获得硕士学位，在加拿大多伦多大学（University of Toronto）获得博士学位，随后在美国俄勒冈大学（University of Oregon）的Monte Westerfield教授斑马鱼发育遗传实验室 从事 博士后研究，2009年加入北京大学。刘东研究员长期从事斑马鱼发育遗传学研究，在脊椎动物外周感觉器官的发育机制和听觉形成与再生机制等多方面取得了突出的成果。在Development, Developmental Dynamics, Molecular Endocrinology, Journal of Biological Chemistry等国际知名学术刊物上发表专业研究论文20多篇。

主要代表论文：

  1. Choy S.W., ChengC.W., Lee S.T., Li V.W.T., Hui M.N.Y., Hui C.,Liu D.and Cheng S.H. A transcriptional cascade ofirx 1a andirx 2a controlsshhexpression during zebrafish retinogenesis, Developmental Dynamics, 2010, in press.
  2. Shen Y.C., Jeyabalan A.K., Wu K.L., Hunker K.L., Kohrman D.C., Thompson D.L.,Liu D. and Barald K.F. , The transmembrane inner ear (tmie) gene contributes to vestibular and lateral line development and function in the zebrafish (Danio rerio) , Developmental Dynamics , 2008 , 237:941
  3. Rotllant J.,Liu D., Yan Y., Postlethwait J.H., Westerfield M. and Du S. , Sparc (Osteonectin) functions in morphogenesis of pharyngeal skeleton and inner ear , Matrix Biology , 2008 , 27: 561
  4. Hans S., Christison J.,Liu D.and Westerfield M. , Fgf-dependant otic induction requires competence provided by Foxi1 and Dlx3b , BMC Developmental Biology , 2007 , 7: 5
  5. Yan Y-L., Willoughby J.,Liu D., Crump J.G., Wilson C., Miller C.T., Singer A., Kimmel C., Westerfield M. and Postlethwait J.H. , A pair of Sox: distinct and overlapping functions of zebrafish Sox9 co-orthologs in craniofacial and pectoral fin development , Development , 2005 , 132: 1069
  6. Hans S.,Liu D.and Westerfield M. , Pax8 and Pax 2a function synergistically in otic specification, downstream of the Foxi1 and Dlx3b transcription factors , Development , 2004 , 131: 5091
  7. Liu D., Chu H., Maves L., Yan Y-L., Morcos P. A., Postlethwait J.H. and Westerfield M. , Fgf3 and Fgf8 dependent and independent transcription factors are required for otic placode specification , Development , 2003 , 130:2213
  8. Yan Y-L., Miller C. T., Nissen R., Singer A.,Liu D., Kirn A., Draper B., Willoughby J., Morcos P. A., Amsterdam A., Chung B., Westerfield M., Haffter P., Hopkins N., Kimmel C. and Postlethwait J. H. , Zebrafish sox9 gene required for cartilage morphogenesis , Development , 2002 , 129: 5065
  9. Lin W-W, Wang H-W, Chen J-C, Sum C.,Liu D., Hew C.L. and Chung B-c. , Zebrafish ftz-f1 gene has two promoters, is alternatively spliced, and is expressed in digestive organs , Biochemical Journal , 2000 , 348: 439
  10. Liu D., Chandy M., Lee S-K. Le Dréan Y., Xiong F., Lee J.W. and Hew C. L. , A zebrafish Ftz-F1 (fushi tarazu factor 1) homologue requires multiple sub-domains in the D and E regions for its transcriptional activity , The Journal of Biological Chemistry , 2000 , 275:16758
  11. Ando H., Ando J., Le Dréan Y.,Liu D., Xiong F. and Hew C. L. , Salmon gonadotropin II beta-subunit gene promoter contains multiple DNA elements responsible for stimulation by gonadotropin-releasing hormone through protein kinase C-dependent and independent pathways , Molecular and cellular Endocrinology , 1999 , 157: 143
  12. Liu D., Le Dréan Y., Ekker M., Xiong F. and Hew C. L. , Teleost FTZ-F1 homolog and its splicing variant determine the expression of salmon gonadotropin II beta gene , Molecular Endocrinology , 1997 , 11: 877
  13. Le Dréan Y.,Liu D., Xiong F. and Hew C. L. , Presence of distinct cis-acting elements on gonadotropin gene promoters in diverse species dictates the selective recruitment of different transcription factors by steroidogenic factor 1 , Molecular and Cellular Endocrinology , 1997 , 135: 31
  14. Le Dréan Y.,Liu D., Wong A. O. L., Xiong F. and Hew C. L. 1996. , Steroidogenic factor1 and estradiol receptor act in synergism to regulate the expression of the salmon gonadotropin II beta subunit gene , Molecular Endocrinology , 1996 , 10: 217
  15. Wong A. O. L., Le Dréan Y.,Liu D., Hu Z., Du S. and Hew C. L. , Induction of Chinook salmon growth hormone promoter activity by the cAMP-dependent pathway involves two cAMP-response elements with CGTCA motif and the pituitary-specific transcription factor Pit-1 , Endocrinology , 1996 , 137: 1775
  16. Liu D., Xiong F. and Hew C. L. , Functional analysis of estrogen-responsive elements in Chinook salmon (Oncorhynchus tschawytscha) gonadotropin II beta subunit gene , Endocrinology , 1995 , 136: 3486
  17. Suzuki K.,Liu D.and Hew C. L. , A gene encoding Chinook salmon (Oncorhynchus tschawytscha) gonadotropin alpha subunit: gene structure and promoter analysis in primary pituitary cells , Molecular and Marine Biology and Biotechnology , 1995 , 4: 10
  18. Xiong F.,Liu D., Elsholtz H. P. and Hew C. L. , The Chinook salmon gonadotropin II beta subunit gene contains a strong minimal promoter with a proximal negative element , Molecular Endocrinology , 1994 , 8: 771
  19. Xiong F.,Liu D., Le Dréan Y., Elsholtz H. P. and Hew C. L. , Differential recruitment of steroid hormone response elements may dictate the expression of the pituitary , Molecular Endocrinology , 1994 , 8:782
  20. Xie Y.,Liu D., Zou J., Li G. and Zhu Z. , Gene transfer via electroporation in fish , Aquaculture , 1993 , 111: 207
  21. Xie Y.,Liu D., Zou J. and Zhu Z. , Gene transfer in the fertilized eggs of loach via electroporation , Acta Hydrobiologica Sinica , 1989 , 13: 387