李亚南，www.优德88.cpm 转化医学研究院博士后。2019年于www.优德88.cpm 获得免疫学硕士学位，2023年于罗马第二大学University of Rome Tor Vergata获得生物化学与分子生物学博士学位。
邮箱:yanan201509@163.com
研究方向:干细胞与免疫调控；巨噬细胞与肝脏损伤修复
代表性研究论文：（#共同第一作者）
1.Li Y, Wang T, Li X, Li W, Lei Y, Shang Q, Zheng Z, Fang J, Cao L, Yu D, Meng Z, Zhang S, Liu R, Liu C, Xu C, Ding Y, Chen Y, Candi E, Melino G, Wang Y, Shi Y, Shao C. SOD2 promotes the immunosuppressive function of mesenchymal stem cells at the expense of adipocyte differentiation.Molecular Therapy. 2024 Feb 3:S1525-0016(24)00031-5
2.Li Y, Giovannini S, Wang T, Fang J, Li P, Shao C, Wang Y; TOR centre; Shi Y, Candi E, Melino G, Bernassola F. p63: a crucial player in epithelial stemness regulation.Oncogene. 2023 Nov;42(46):3371-3384.
3. Ma H#,Li Y#, Song L, Liu R, Li X, Shang Q, Wang Y, Shao C, Shi Y. Macrophages inhibit adipogenic differentiation of adipose tissue derived mesenchymal stem/stromal cells by producing pro-inflammatory cytokines.Cell & Bioscience. 2020 Jul 20;10:88.
4. Zheng Z,Li Y, Jia S, Zhu M, Cao L, Tao M, Jiang J, Zhan S, Chen Y, Gao PJ, Hu W, Wang Y, Shao C, Shi Y. Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3.Nature Communications. 2021 Oct 27;12(1):6202.
5. Shang Q#, Chu Y#,Li Y, Han Y, Yu D, Liu R, Zheng Z, Song L, Fang J, Li X, Cao L, Gong Z, Zhang L, Chen Y, Wang Y, Shao C, Shi Y. Adipose-derived mesenchymal stromal cells promote corneal wound healing by accelerating the clearance of neutrophils in cornea.Cell Death & Disease. 2020 Aug 26;11(8):707.
6.Li X#, Shang B#,Li YN,Shi Y, Shao C. IFNγ and TNFα synergistically induce apoptosis of mesenchymal stem/stromal cells via the induction of nitric oxide.Stem Cell Research & Therapy. 2019 Jan 11;10(1):18. doi: 10.1186/s13287-018-1102-z.
7.Bu W, Sun X, Xue X, Geng S, Yang T, Zhang J,Li Y, Feng C, Liu Q, Zhang X, Li P, Liu Z, Shi Y, Shao C. Early onset of pathological polyploidization and cellular senescence in hepatocytes lacking RAD51 creates a pro-fibrotic and pro-tumorigenic inflammatory microenvironment.Hepatology. 2024 Mar 11.
8. Fang J, Hou P, Liu S, Zuo M, Liu Z, Chen W, Han Y,Li Y, Wang T, Feng C, Li P, Shao C, Shi Y. NAD+ salvage governs the immunosuppressive capacity of mesenchymal stem cells.Cellular & Molecular Immunology. 2023 Oct;20(10):1171-1185.
9. Ding Y, Gong P, Jiang J, Feng C,Li Y, Su X, Bai X, Xu C, Liu C, Yang J, Fang J, Ji X, Chen Y, Li P, Guo L, Shao C, Shi Y. Mesenchymal stem/stromal cells primed by inflammatory cytokines alleviate psoriasis-like inflammation via the TSG-6-neutrophil axis.Cell Death & Disease. 2022 Nov 25;13(11):996.
10. Song L, Cao L, Liu R, Ma H,Li Y, Shang Q, Zheng Z, Zhang L, Zhang W, Han Y, Zhang X, Yang H, Wang Y, Melino G, Shao C, Shi Y. The critical role of T cells in glucocorticoid-induced osteoporosis.Cell Death & Disease. 2020 Dec 14;12(1):45.