邵常顺，www.优德88.cpm 特聘教授、博士生导师。获美国印第安纳大学博士学位。曾任罗格斯大学副教授、山东大学教授、实验畸形学教育部重点实验室主任等职。现任Frontiers in Oncology副主编、Mutation Res等杂志编委。承担过多项国家自然科学基金和科技部课题。累计发表SCI论文170余篇，引用超过20，000次（Google Scholar）。以通讯作者在Aging Cell、Cancer Res、Cell Mol Immunol、Hepatol、J Cell Biol、Mol Ther、Nature Genet、Nature Commun、Oncogene、Redox Biol等杂志发表SCI论文60余篇。
研究方向：活性氧对细胞命运及功能的调控作用、细胞衰老与组织再生、干细胞/癌细胞与免疫微环境交互调控
承担项目：
1.国家自然科学基金（32150710523），2022/01-2023/12，160万元，项目负责人
2.国家重点研发计划“干细胞研究与器官修复”专项（2021YFA1100602），2021/12-2026/06，课题负责人（586万元）
近五年代表性文章（*通讯作者）：
1.Bu W, Sun X, Xue X, Geng S, Yang T, Zhang J, Li Y, Feng C, Liu Q, Zhang X, Li P, Liu Z, Shi Y,Shao C*. Early onset of pathological polyploidization and cellular senescence in hepatocytes lacking RAD51 creates a pro-fibrotic and pro-tumorigenic inflammatory microenvironment.Hepatology. 2024 Mar 11. doi: 10.1097/HEP.0000000000000821. Epub ahead of print. PMID: 38466833.
2.Li Y, Wang T, Li X, Li W, Lei Y, Shang Q, Zheng Z, Fang J, Cao L, Yu D, Meng Z, Zhang S, Liu R, Liu C, Xu C, Ding Y, Chen Y, Candi E, Melino G, Wang Y, Shi Y*,Shao C*. SOD2 promotes the immunosuppressive function of mesenchymal stem cells at the expense of adipocyte differentiation.Mol Ther. 2024 Feb 3:S1525-0016(24)00031-5. doi: 10.1016/j.ymthe.2024.01.031. Epub ahead of print. PMID: 38310354.
3.Cui D, Wang Z, Dang Q, Wang J, Qin J, Song J, Zhai X, Zhou Y, Zhao L, Lu G, Liu H, Liu G, Liu R,Shao C*, Zhang X*, Liu Z*. Spliceosome component Usp39 contributes to hepatic lipid homeostasis through the regulation of autophagy.Nat Commun. 2023 Nov 3;14(1):7032. doi: 10.1038/s41467-023-42461-6. PMID: 37923718; PMCID: PMC10624899.
4.Chu Y, Jiang Z, Gong Z, Ji X, Zhu M, Shang Q, Gong P, Cao L, Chen Y, Li P,Shao C*, Shi Y*. PML-mediated nuclear loosening permits immunomodulation of mesenchymal stem/stromal cells under inflammatory conditions.Cell Prolif. 2023 Oct 20:e13566. doi: 10.1111/cpr.13566. Epub ahead of print. PMID: 37864298.
5.Liu Z, Hou P, Fang J, Zhu J, Zha J, Liu R, Ding Y, Zuo M, Li P, Cao L, Feng C, Melino G,Shao C*, Shi Y*. Mesenchymal stromal cells confer breast cancer doxorubicin resistance by producing hyaluronan.Oncogene. 2023 Oct;42(44):3221-3235. doi: 10.1038/s41388-023-02837-w. Epub 2023 Sep 14. PMID: 37704784.
6.Fang J, Hou P, Liu S, Zuo M, Liu Z, Chen W, Han Y, Li Y, Wang T, Feng C, Li P,Shao C*, Shi Y*. NAD+salvage governs the immunosuppressive capacity of mesenchymal stem cells.Cell Mol Immunol. 2023 Oct;20(10):1171-1185. doi: 10.1038/s41423-023-01073-2. Epub 2023 Aug 14. PMID: 37580400; PMCID: PMC10541442.
7.Zuo M, Fang J, Huang P, Liu S, Hou P, Wang S, Liu Z, Feng C, Cao L, Li P, Shi Y*,Shao C*. IL4I1-catalyzed tryptophan metabolites mediate the anti-inflammatory function of cytokine-primed human muscle stem cells.Cell Death Discov. 2023 Jul 28;9(1):269. doi: 10.1038/s41420-023-01568-x. PMID: 37507432; PMCID: PMC10382538.
8.Li P, Ou Q, Shi S*,Shao C*. Immunomodulatory properties of mesenchymal stem cells/dental stem cells and their therapeutic applications.Cell Mol Immunol. 2023 Jun;20(6):558-569. doi: 10.1038/s41423-023-00998-y. Epub 2023 Mar 27. PMID: 36973490; PMCID: PMC10040934.
9.Wang Z, Wang S, Qin J, Zhang X, Lu G, Liu H, Guo H, Wu L, Shender VO,Shao C*, Kong B*, Liu Z*. Splicing factor BUD31 promotes ovarian cancer progression through sustaining the expression of anti-apoptotic BCL2L12.Nat Commun. 2022 Oct 21;13(1):6246. doi: 10.1038/s41467-022-34042-w. PMID: 36271053; PMCID: PMC9587234.
10.Han Y, Yang J, Fang J, Zhou Y, Candi E, Wang J, Hua D,Shao C*, Shi Y*. The secretion profile of mesenchymal stem cells and potential applications in treating human diseases.Signal Transduct Target Ther. 2022 Mar 21;7(1):92. doi: 10.1038/s41392-022-00932-PMID: 35314676; PMCID: PMC8935608.
11.Hao X, Bu W, Lv G, Xu L, Hou D, Wang J, Liu X, Yang T, Zhang X, Liu Q, Gong Y,Shao C*. Disrupted mitochondrial homeostasis coupled with mitotic arrest generates antineoplastic oxidative stress.Oncogene. 2022 Jan;41(3):427-443. doi: 10.1038/s41388-021-02105-9. Epub 2021 Nov 12. PMID: 34773075; PMCID: PMC8755538.
12.Zheng Z, Li YN, Jia S, Zhu M, Cao L, Tao M, Jiang J, Zhan S, Chen Y, Gao PJ, Hu W, Wang Y*,Shao C*, Shi Y*. Lung mesenchymal stromal cells influenced by Th2 cytokines mobilize neutrophils and facilitate metastasis by producing complement C3.Nat Commun. 2021 Oct 27;12(1):6202. doi: 10.1038/s41467-021-26460-z. PMID: 34707103; PMCID: PMC8551331.
13.Hang Y, Ma X, Liu C, Li S, Zhang S, Feng R, Shang Q, Liu Q, Ding Z, Zhang X, Yu L, Lu Q*,Shao C*, Chen H*, Shi Y, He J, Kaplan DL. Blastocyst-Inspired Hydrogels to Maintain Undifferentiation of Mouse Embryonic Stem Cells.ACS Nano. 2021 Sep 28;15(9):14162-14173. doi: 10.1021/acsnano.0c10468. Epub 2021 Sep 13. PMID: 34516077.
14.Liu R, Li X, Ma H, Yang Q, Shang Q, Song L, Zheng Z, Zhang S, Pan Y, Huang P, Fang J, Li Y, Liu Z, Cao L, Feng C, Gong Z, Chen Y, Wang Y, Melino G,Shao C*, Shi Y*. Spermidine endows macrophages anti-inflammatory properties by inducing mitochondrial superoxide-dependent AMPK activation, Hif-1α upregulation and autophagy.Free Radic Biol Med. 2020 Dec;161:339-350. doi: 10.1016/j.freeradbiomed.2020.10.029. Epub 2020 Oct 24. PMID: 33122005.
15.Xu L, Wu T, Lu S, Hao X, Qin J, Wang J, Zhang X, Liu Q, Kong B, Gong Y, Liu Z,Shao C*. Mitochondrial superoxide contributes to oxidative stress exacerbated by DNA damage response in RAD51-depleted ovarian cancer cells.Redox Biol. 2020 Sep;36:101604. doi: 10.1016/j.redox.2020.101604. Epub 2020 Jun 8. PMID: 32554304; PMCID: PMC7303666.