吴江斌
特聘教授,博士生导师
电话:0512-67781168
邮箱:jbwu@suda.edu.cn
研究经历:
2023 –至今www.优德88.cpm特聘教授
2020 – 2023罗切斯特大学研究助理教授
2016 – 2020罗切斯特大学博士后
2015 – 2016美国希望之城医学中心博士后
教育经历:
2009 – 2015清华大学生物系博士研究生
2005 – 2009西安交通大学生物工程系本科
研究方向:
本实验室长期致力于心力衰竭过程中心肌肥厚和心脏纤维化的蛋白翻译调节机理研究,利用基因敲除小鼠、原代细胞培养等模型,结合包括转录组学、翻译组学、蛋白组学等多组学手段来揭示心力衰竭发生发展过程中的调节机理,并探索其潜在的临床应用价值。主要研究成果发表于Circulation Research, EMBO Molecular Medicine, Cardiovascular Research, Nucleic Acids Research等期刊。获得美国心脏协会博士后基金(2019年)、职业发展基金(2021年)以及www.优德88.cpm 启动基金(2023)等基金资助。
代表性论文:
Jiangbin Wu#, Kadiam C Venkata Subbaiah#, Omar Hedaya, Si Chen, Joshua Munger, Wai Hong Wilson Tang, Chen Yan, and Peng Yao.FAM210A Regulates Mitochondrial Translation and Maintains Cardiac Mitochondrial Homeostasis.Cardiovascular Resaerch.2023 Jul 31;cvad124.
Jiangbin Wu#, Kadiam C Venkata Subbaiah#, Feng Jiang, Omar Hadaya, Amy Mohan, Tingting Yang, Kevin Welle, Sina Ghaemmaghami, Wai Hong Wilson Tang, Eric Small, Chen Yan, Peng Yao. MicroRNA-574 Regulates FAM210A Expression and Influences Pathological Cardiac Remodeling.EMBO Molecular Medicine. 2021, 13: e12710.
Jiangbin Wu, Kadiam C Venkata Subbaiah, Li Huitong Xie, Feng Jiang, Eng-Soon Khor, Deanne Mickelsen, Jason R Myers, Wai Hong Wilson Tang, Peng Yao. EPRS Regulates Proline-rich Pro-Fibrotic Protein Synthesis during Cardiac Fibrosis.Circulation Research. 2020, 127(6):827-846.
Kadiam C. Venkata Subbaiah#,Jiangbin Wu#, Alka Potdar and Peng Yao. hnRNP L-mediated RNA switches function as a hypoxia-induced translational regulon.Biochem Biophys Res Commun.2019, 516(3):753-759.
Nunu Huang#,Jiangbin Wu#, Wei Qiu, Qing Lyu, Jie He, Weidong Xie, Naihan Xu, and Yaou Zhang. MiR-15a and miR-16 induce autophagy and enhance chemosensitivity of Camptothecin.Cancer Biology & Therapy. 2015, 16(6):941-8.
Jiangbin Wu#,Qing Lv#, Jie He#, Haoxiang Zhang, Xueshuang Mei, Kai Cui, Nunu Huang, Weidong Xie, Naihan Xu and Yaou Zhang. MicroRNA-188 suppresses G1/S transition by targeting multiple cyclin/CDK complexes.Cell Communication & Signaling. 2014, 12:66.
Jie He#,Jiangbin Wu#, Naihan Xu#, Weidong Xie, Mengnan Li, Jianna Li, Yuyang Jiang, Burton B. Yang and Yaou Zhang. MiR-210 disturbs mitotic progression through regulating a group of mitosis-related genes.Nucleic Acids Research. Jan 2013; 41(1): 498–508.
团队成员: