安艳

发布时间：2017-10-11浏览次数：9228

安艳（1969.09-），女，回族，辽宁省营口市人

中共党员，研究员、博士生导师

电话：0512-65880910（办）

邮箱：annine@suda.edu.cn

dranyan@126.com

www.优德88.cpm 教师个人主页：http://web.suda.edu.cn/annine/

1．教育背景

2002.04–2005.03日本大学药学部博士研究生

1998.09–2001.07吉林大学白求恩医学院博士研究生

1993.09–1996.07中国辐射防护研究院环境医学研究所硕士研究生

1988.09–1993.07山西医学院预防医学系大学本科

2．科研经历

2008.07–至今 www.优德88.cpm 医学部公共卫生学院研究员（2008.07起博导）

2005.04–2008.06山东省医学科学院放射医学研究所研究员（2005.07起硕导）

2002.04–2005.03日本大学药学部日本文部科学省资助国费留学生

2000.09–2002.03日本大学药学部外国人研究员

1998.09–1998.12日本国放射线医学综合研究所日本科技厅科技交流访问学者

1996.08–2005.03中国辐射防护研究院环境医学研究所助理研究员

3．研究方向

环境（砷、氟等）毒理学和职业（铅）毒理学

4.主持或参加科研项目（课题）

（12）国家自然科学基金委员会，面上项目，81872646，砷致细胞恶性转化过程中ROS-自噬-凋亡的调控机制，2019-01至2022-12，在研，主持。

（11）国家自然科学基金委员会与日本学术振兴会合作交流项目，81811540034，砷致细胞恶性转化过程中二甲基化胂对转录因子Nrf2的作用研究，2018-04至2020-12，已结题，主持；

（10）国家自然科学基金委员会，面上项目，81573173，砷致细胞恶性转化过程中转录因子Nrf2的作用及调控机制，2016-01至2019-12，已结题，主持；

（9）高等学校博士学科点专项科研基金联合资助课题，20123201110012，砷致肺氧化损伤对Keap1-Nrf2/ARE通路作用研究，2013-01至2015-12，已结题，主持。

（8）国家自然科学基金委员会，重大国际（地区）合作研究项目，81020108028，线粒体介导的遗传损伤在氡致肺癌中的作用机制，2011-01至2013-12，已结题，参与。

（7）环保部专项计划项目“《国家环境污染物健康风险名录》生物分册”（P112600611）,2011.01-2012.12，已结题，主持.

（6）日本文部科学省日本学术振兴会研究辅助金资助项目，中日国际合作课题，20390173，不同人种通过不同途径暴露于不同形态的砷化合物与砷致癌危险度间关系研究，2007-04至2012-03，已结题，中方主持。

（5）教育部留学回国人员科研启动基金项目：“砷致癌氧化应激机制研究－无机砷主要代谢产物二甲基胂酸致小鼠肺组织损伤形态计量学研究”，2007.01－2008.12，已结题，主持.

（4）山东省优秀中青年科学家科研奖励基金项目：“甲基胂化物致小鼠肺组织损伤超微结构形态计量学研究”（No.2006BS03067），2007.01－2008.12，已结题，主持.

（3）人事部留学回国人员科技活动择优资助项目：“砷甲基化代谢模式与砷中毒关系研究”，2007.01-12，已结题，主持。

（2）国家自然科学基金委员会，专项基金项目，30540018，砷中毒地区不同形态砷化合物暴露水平与砷致皮肤病变间关系研究，2006-01至2006-12，已结题，主持。

（1）“九五”国家重点科技攻关计划项目：“公害病判定技术研究 ”（No.96-911-07-03），1996-2001，主要参与人。

5．科研成果

在Science of The Total Environment、Free Radical Biology and Medicine、Ecotoxicology and Environmental Safety、Toxicology and Applied Pharmacology、Cancer Letters、《中华地方病学杂志》等国内、外专业学术期刊上以第一作者或通讯作者发表论文110余篇；为首荣获核工业部科学技术进步三等奖、省科技进步三等奖以及山东省第八届青年科技奖等省、部级各级奖项15项；主编和参编著作5部，申请国家发明专利1项；担任Ecotoxicology and Environmental Safety、Environment International、Environmental Pollution、Toxicology Research、中华地方病学杂志等多家杂志的审稿人及编委。

I.代表性论著（通讯作者）：

（7）Qi Kong#; Hanyi Deng#; Chunchun Li#; Xiaojuan Wang; Yasuyo Shimoda; Shasha Tao; Koichi Kato; Jie Zhang*; Kenzo Yamanaka*;Yan An*. Sustained expression of NRF2 and its target genes induces dysregulation of cellular proliferation and apoptosis is associated with arsenite-induced malignant transformation of human bronchial epithelial cells.Science of The Total Environment.2021, 734: 143840.

PMID:33261869

DOI:10.1016/j.scitotenv.2020.143840

（6）Luna Wang#; Rui Yan#; Qianlei Yang; Heran Li; Jie Zhang; Yasuyo Shimoda; Koichi Kato; Kenzo Yamanaka;Yan An. Role of GH/IGF axis in arsenite-induced developmental toxicity in zebrafish embryos.Ecotoxicology and Environmental Safety. 2020, 201: 110820.

DOI:10.1016/j.ecoenv.2020.110820

（5）Jing wu#; Yiping Ni#; Qianlei Yang#; Jiayuan Mao;Yasuyo Shimoda; XueruiZhu; Luna Wang; Haixuan Xia; Shasha Tao; Koichi Kato; Jie Zhang; Dapeng Wang*; Kenzo Yamanaka;Yan An. Long-term arsenite exposure decreases autophagy by increased release of Nrf2 in transformed human keratinocytes.Science of The Total Environment.2020, 734: 139425.

DOI:10.1016/j.scitotenv.2020.139425

（4）Xu Yang; Dapeng Wang; Yuan Ma; Xiguo Xu; Yingying Zhao; Zhen Zhu; Xiaojuan Wang; Hanyi Deng; Chunchun Li; Fenfang Gao; Jian Tong; Kenzo Yamanaka;Yan An.Continuous Activation of Nrf2 and Its Target Antioxidant Enzymes Leads to Arsenite-Induced Malignant Transformation of Human Bronchial Epithelial Cells.Toxicology and Applied Pharmacology. 2015. 289：231-239

DOI:10.1016/j.taap.2015.09.020

（3）Dapeng Wang; Yuan Ma; Xu Yang; Xiguo Xu; Yingying Zhao; Zhen Zhu; Xiaojuan Wang; Hanyi Deng; Chunchun Li; Fenfang Gao; Jian Tong; Kenzo Yamanaka;Yan An.Hypermethylation of Keap1 Gene Inactivates Its Function and Promotes Nrf2 Nuclear Accumulation Is Involved in Arsenite-Induced Human Keratinocyte Transformation.Free Radical Biology and Medicine. 2015.89：209-219.

DOI:10.1016/j.freeradbiomed.2015.07.153

（2）Yan An#, Koichi Kato, Masauki Nakano, Hiroshi Otsu, Shoji Okada, Kenzo Yamanaka*. Specific Induction of Oxidative Stress in Terminal Bronchiolar Clara Cells during Dimethylarsenic-Induced Lung Tumor Promoting Process in Mice.Cancer Letters.2005, 230(1):57-64

DOI:10.1016/j.canlet.2004.12.029

（1）Yan An#,Zenglin Gao, Zhongwen Wang, Shaohe Yang, Jianfen Liang, Yan Feng, Koichi Kato, Masauki Nakano, Shoji Okada, Kenzo Yamanaka*. Immunohistochemical Analysis of Oxidative DNA Damage in Arsenic-Related Human Skin Samples from Arsenic-Contaminated Area of China.Cancer Letters.2004,214(1): 11-18.

DOI:10.1016/j.canlet.2004.04.005

II.主编和参编论著

（5）《毒理学试验方法与技术》，人民卫生出版社，2018年3月第七版（52.5万字，ISBN 978-7-117-27879-9），参编.

（4）《环境毒理学基础》，人民卫生出版社，2018年11月第三版，（53万字，ISBN 978-7-04-050623-5）参编.

（3）《毒理学基础》，人民卫生出版社，2017年8月第七版（75.3万字，ISBN 978-7-117-24633-0/R•24634），参编.

（2）《现代环境毒理学》，中国环境出版社，2015年12月第一版（146万字，ISBN 978-7-5111-2381-7），参编.

（1）《国家污染物环境健康风险名录.生物分册》，中国环境出版社，2013年12月第一次印刷（36万字，ISBN 978-7-5111-1678-9）,主编.

III.获奖情况：

（14）2020年度优秀党员.

（13）2019年度学院优秀科研工作奖.

（12）2018年度学院优秀科研工作奖.

（11）2018年度考核优秀.

（10）2011年度考核优秀.

（9）山东省科学技术进步三等奖（排名1/10）（2011）.

（8）第五届亚洲毒理学研讨会优秀墙报奖（排名1/8）（2009）.

（7）山东省第八届青年科技奖（2008）.

（6）中国毒理学会首届全国优秀青年科技人才奖（2007）.

（5）国防科学技术二等奖（排名14/42）（2002）.

（4）环境保护科技成果奖(排名14/42)（2001）.

（3）中国核工业总公司科学技术进步三等奖（排名1/8）(1997).

（2）山西省科学技术协会优秀论文三等奖（排名1/10）(1997).

（1）山西省首届青年论文大赛优秀论文二等奖（1/8）（1996）.

IV.授权专利

（20）安艳；严锐；毛佳渊；杨乾磊；夏海璇；孔齐；魏园杰。二甲基亚胂酸致人角质形成细胞恶性转化细胞模型及其构建【ZL2021103053231】（发明专利）。

（19）安艳；严锐；毛佳渊；杨乾磊；夏海璇；孔齐；魏园杰。硫代二甲基胂酸致人角质形成细胞恶性转化细胞模型及其构建【ZL2021101095403】（发明专利）。

（18）景楠；安艳；魏园杰；杨乾磊；严锐。一种溢流自清洁养殖缸【ZL2021207446343】（实用新型）。

（17）花艳丽；安艳；雷婧；肖呈琦。搅拌器【ZL2021205452710】（实用新型）。

（16）雷婧；安艳；花艳丽；肖呈琦。一种western blot抗体洗脱装置【ZL2021203206533】（实用新型）。

（15）肖呈琦；安艳。一种脚踩式酒精喷壶【ZL2020207715491】（实用新型）。

（14）安艳；周淼；黄琳；周吉全；段佩辰。一种简易小鼠粪尿分离及收集装置【专利号：ZL2020207334485】（实用新型）。

（13）安艳；黄琳；周淼；周吉全；段佩辰。一种易于批量清洗移液管的转换器【专利号：ZL2020208994247】（实用新型）。

（12）安艳；张恬。夹闭式灭菌指示带切割器。【专利号：ZL2020206786485】（实用新型）。

（11）张恬；安艳。一种灭菌指示带切割器【专利号：ZL2020206768928】（实用新型）。

（10）徐鑫；安艳；肖艳。一种密封性好的制胶装置。【专利号：ZL2020203907933】

（9）安艳；郭相东。一种化学药品辅助称量装置【专利号：ZL202020770757X】（实用新型）。

（8）安艳；刘婕妤；王嘉祥。一种衣物脱水拧干装置【专利号：ZL2019218655379】（实用新型）。

（7）安艳；刘婕妤；王嘉祥。一种便于清洗的榨汁杯【专利号：ZL2019218945259】（实用新型）。

（6）安艳；刘婕妤；王嘉祥。一种变容式洗碗机【专利号：ZL2019218943380】（实用新型）。

（5）安艳；徐鑫；钱佚航；张钧阳；叶嘉怡。转盘式试管架【专利号：ZL2019210004789】（实用新型）。

（4）安艳；徐鑫；钱佚航；张钧阳；叶嘉怡。用于细胞培养的冻存盒【专利号：ZL2019210013294】（实用新型）。

（3）安艳；刘婕妤；陈晨。一种牙刷【专利号：ZL2018217130627】（实用新型）。

（2）安艳；倪一平。一种用于涂覆蛋白条带的盒【专利号：ZL2018201299739】专（实用新型）。

（1）安艳；倪一平。条带切割装置【专利号：ZL2018201134810】（实用新型）。

6．教学工作

（4）公共卫生学院研究生基础课程《卫生毒理学》和《高级毒理学》

（3）预防医学专业课《卫生毒理学》（双语和全英文教学）

（2）全校公共选修课《环境与健康同行》和《纳米世界》

（1）新生研讨课《环境污染与健康》、《纳米世界漫谈》和《由毒至药：砷的两面性》

7．社会工作

教育部科研基金和科技奖励评审专家

教育部学位论文评审专家

教育部留学回国人员科研启动基金评审专家

科技部国际科技合作计划评审专家

中国博士后基金评审专家

山东省、江西省科技攻关计划项目评审专家

山东省、四川省、河北省、江西省科学技术奖励评审专家

天津市、重庆市、浙江省、广东省、河北省自然科学基金评审专家

广东省高层次人才评审专家

2014-中国环境诱变剂学会活性氧生物学效应专业委员会委员

2017-中国生物物理学会自由基生物学与自由基医学分会理事

2015-中国中西医结合学会时间生物学专业委员会委员

2019-亚洲砷与健康研究联盟理事

2015-江苏省毒理学会基础毒理学专业委员会副主任委员

2020-江苏省预防医学会职业健康专业委员会常委

2014-2018江苏省毒理学会理事

2018-江苏省毒理学会监事

2012-《国外医学医学地理学分册》常务编委

2016-《中华地方病学杂志》编委

(以上信息由教师本人提供)

CURRICULUM VITAE

Yan An

Dec., 2021

GENERAL

Contact Information

Dr. Yan An

Department of Toxicology

School ofPublic Health

Medical College of Soochow University

199 Renai Rd, Suzhou industrial Park, Suzhou 215123, Jiangsu Province, China

Tel: (+86)512-65880910(O)

E-mail:dranyan@126.com

annine@suda.edu.cn

Webpage：http://web.suda.edu.cn/annine/

Education

2005	PhD	Environmental Toxicology	Nihon University College of Pharmacy With Prof. Kenzo Yamanaka
2001	PhD	Radiomedicine	Jilin University Norman Bethune Medical College with Prof. Zenglin Gao
1996	MS	Industrial Hygiene and Occupational Diseases	China Institute for Radiation Protection With Prof. Rusong Chen
1993	B.S.Med	Preventive Medicine	Shanxi Medical University

Positions

2008-	Professor	Department of Toxicology School of Public HealthMedical College of Soochow University
2005-08	Professor	Department of Radiation Effects, Institute for Radiation Medicine, Shandong Academy of Medical Sciences
1996-2005	Research Assistant Professor	Department of Life Science China Institute for Radiation Protection

Honors and awards

2011	Third Prizefor The study on Carcinogenic Mechanisms of Arsenics- Metabolic methylation of arsenic-induced oxidative stress	Science & Technology Advancement Award of Shandong province
2009	Poster award forA case-control study on relationship between arsenic in drinking water and skin lesions in endemic arsenism area of Shanxi province, China	The 5^thInternational Congress of Asia Society of Toxicology（ASIATOX-V）
2008		The introduction of a shortage talents of high-level personnel funded projects in Suzhou city
2008		The 8^thYouth of Sciences & Technology award of Shandong provience,
2011	The National Outstanding Youth Scientists and Technicians Awardfor Carcinogenic Mechanisms of Arsenics- Metabolic methylation of arsenic-induced oxidative stress	The 2^ndSession of National Chinese Youth Scholar Science and Technology Forum of Chinese Society of Toxicology（CST）
2005	Import of foreign talent in Shandong province	Human Resources and Social Security Department of Shandong province
2000- 2005		Japanese Government (MONBUKAGAKUSHO: MEXT) Scholarship
2002	The2^ndclass awardfor The Study on Judging Criterion of Public Nuisance Disease	National Defense Sciences & Technology Award,
2001	Excellent achievement awardon Judging Criterion of Public Nuisance Disease	State Environmental Protection Administration of China
1999	The3^rdclass awardfor The Morphometric Study of¹³¹I-Induced Injury in Rat Thyroid	The 10^thConference of Shanxi Science & Technology
1999	Excellent achievement awardon Carcinogenesis of Arsenic	The Organizing Committee of International Cooperative Symposium for Global Telemedicine Exchange of Excellent Studies on Oriental & Occidental Medicine,
1999	Awarded a grade of International Certificate ofExcellent Papersforthe study on TheRetentionPatternof Radioiodine inRatThyroid and itsDoseEvaluation	World Network of Traditional Chinese Medicine U.K.
1998	The2^ndclass awardfor The study on The Retention Pattern of Radioiodine in Rat Thyroid and its Dose Evaluation	The 2^ndDevelopment Conference of Sciences & Technology of Huazhong Area
1998	The3^rdclass awardforThe study onTheMorphometricStudy of¹³¹I-Induced Injury inRatThyroid	Science & Technology Advancement Award of Ministry of Nucleus Industry of China
1996	The2^ndclass awardforThe study onTheRetentionPattern of Radioiodine in RatThyroidand itsDose Evaluation	The 1^stConference of the Youth of Sciences & Technology of Shanxi

INTERNATIONAL EXPERIENCE

Oct. 2000-Mar. 2005Department of Environmental Toxicology and Carcinogenesis, Nihon University College of Pharmacy, Japan.

Researchstudent of Graduate School of Nihon University as a Japanese Government (MONBUSHO) Scholarship student

Sept.1998-Dec.1998National Institute of Radiation Sciences, Japan

Japan Science&TechnologyAgency Scientist ExchangeProgram

RESEARCH

Research statement

I am a toxicologist with a focus on Mechanism and Prevention of Xenobiotics Poisoning, Biochemical and Molecular Toxicology, and The Mechanism of Chemical Carcinogenesis on Redox Stress. I have been conducting the molecular mechanisms of the toxicities of environmental chemicals.Using cell lines and zebrafish embryos as model systems, and dissect the functions of signal pathways. I have raised the hypothesis that the metabolic process associated with the methylation of inorganic arsenicals, the subsequent metabolic sulfurization, and the chemical properties of their intermediate active metabolites play an important role in arsenic-induced Redox-stress Response Capacity in arsenic-induced cell transformation.

Major focuses of my current work are: (1) Regulative role of Redox-stress Response Capacity in arsenic-induced human cell transformation. (2) Environmentally relevant concentrations of chemicals induced developmental toxicity and oxidative responses.

External competitive grants as PI

I have received grants from the following funding sources:

3. National Natural Science Foundation of China（NSFC）“Regulative role of transcription factor Nrf2 in arsenic-induced human keratinocytes transformation（No.81573173）”）, 2016.01-2019.12；

2. Chinese Natural Science Foundationof International Cooperation and Exchanges（NSFC—JSPS）“Investigating the Effect of Dimethylated Arsenic Species on Nrf2 in Arsenic-induced Human Keratinocytes Transformation（No.81811540034）”）, 2018.04-2020.12.

1. National Natural Science Foundation of China（NSFC）“Regulative role of ROS on autophagy and apoptosis in arsenic-induced human keratinocytes transformation（No.818172646）”）, 2018.01-2022.12.

Publication list

ISI Researcher ID:http://www.researcherid.com/rid/K-8337-2016

ORCID iD:https://orcid.org/0000-0003-2838-8169

Web of Science ResearcherID:K-8337-2016;M-9831-2019

Papers in ISI indexed journals(corresponding author)

Year 2021

33. Jie Ding; Rui Yan; Luna Wang; Qianlei Yang; Xiaoyun Zhang; Nan Jing; Yuanjie Wei; Hengdong Zhang*; Yan An*. Using Alizarin Red Staining to Detect Chemically Induced Bone Loss in Zebrafish Larvae.Journal of Visualized Experiments.2021,e63251.

PMID:

DOI:

32.Qi Kong#; Hanyi Deng#; Chunchun Li#; Xiaojuan Wang;Yasuyo Shimoda; Shasha Tao;Koichi Kato; Jie Zhang*; Kenzo Yamanaka*;Yan An*. Sustained expression of NRF2 and its target genes induces dysregulation of cellular proliferation and apoptosis is associated with arsenite-induced malignant transformation of human bronchial epithelial cells.Science of The Total Environment.2021, 756: 143840.

PMID:33261869

DOI:10.1016/j.scitotenv.2020.143840.

Before 2020

31. Runa Wang#; Rui Yan#; Qianlei Yang; Heran Li; Jie Zhang;Yasuyo Shimoda;Koichi Kato; Kenzo Yamanaka*;Yan An*. Role of GH/IGF axis in arsenite-induced developmental toxicity in zebrafish embryos.Ecotoxicology and Environmental Safety.2020, 201: 110820.

PMID:32531574

DOI:10.1016/j.ecoenv.2020.110820

30.Jiaoyuan Mao#;Qianlei Yang#;Makoto Miyazawa;Motofumi Miura; Luna Wang^a; Haixuan Xia^a;Koichi Kato; Kenzo Yamanaka*;Yan An*. Possible differences in the mechanism of malignant transformation of HaCaT cells by arsenite and its dimethyl metabolites, particularly dimethylthioarsenics.Journal of Trace Elements in Medicine and Biology.2020, 61: 126544.

DOI:10.1016/j.jtemb.2020.126544

29.Runa Wang#; Rui Yan#; Qianlei Yang; Heran Li; Jie Zhang; Yasuyo Shimoda; Koichi Kato; Kenzo Yamanaka;Yan An. Role of GH/IGF axis in arsenite-induced developmental toxicity in zebrafish embryos.Ecotoxicology and Environmental Safety.2020, 201: 110820.

DOI:10.1016/j.ecoenv.2020.110820

28.Jing wu#; Yiping Ni#; Qianlei Yang#; Jiayuan Mao;Yasuyo Shimoda; XueruiZhu; Luna Wang; Haixuan Xia; Shasha Tao; Koichi Kato; Jie Zhang; Dapeng Wang; Kenzo Yamanaka;Yan An. Long-term arsenite exposure decreases autophagy by increased release of Nrf2 in transformed human keratinocytes.Science of The Total Environment.2020, 734: 139425.

DOI:10.1016/j.scitotenv.2020.139425

27. Jing wu; Yiping Ni; Xiaojuan Wang; Qianlei Yang;Jiayuan Mao; Jian Tong; Jie Zhang*; Yan An*.Role of mitochondrial DNA in oxidative damage induced by sodium arsenite in human bronchial epithelial cells.Journal of Toxicology and Environmental Health-part A. 2019, DOI: 10.1080/15287394.2019.1686108.

DOI:10.1080/15287394.2019.1686108

26. Jing Wu; Jie Zhang; Jihua Nie; Junchao Duan; Yanfeng Shi; Lin Feng; Xiaozhe Yang;Yan An; Zhiwei Sun. The chronic effect of amorphous silica nanoparticles and benzo[a]pyrene co-exposure at low dose in human bronchial epithelial BEAS-2B cells.Toxicology Research. 2019.

DOI:10.1039/c9tx00112c

25. Qianlei Yang; Hanyi Deng; Haixuan X；Mengchuan Xu; Guotao Pan; Jiayuan Mao; Liqian Qin; Jie Zhang; Tom K Hei; Shasha Tao; Kenzo Yamanaka;Yan An. High Nrf2 expression predicted poor prognosis in patients with lung cancer: A meta-analysis of cohort studies.Free Radical Research. 2019,

DOI:10.1080/10715762.2019.1642472.

24. Qianlei Yang; Zhen Zhu; Luna Wang; Haixuan Xia; Xiaojuan Wang; Jing Wu; Koichi Kato; Heran Li; Jie Zhang; Kenzo Yamanaka;Yan An. The protective effect of silk fibroin on high glucose induced insulin resistance in HepG2 cells.Environmental Toxicology and Pharmacology. 2019, 69:66-71.

DOI:10.1016/j.etap.2019.04.001.

23. Jiting Liu; Li Zhang; Lixia Feng; Ming Xu; Yue Gao; Peng Zhou; Zhengmin Yu; Baoli Zhu;Yan An; Hengdong Zhang. Association Between Single Nucleotide Polymorphism (rs4252424) in TRPV5 Calcium Channel Gene and Lead Poisoning in Chinese Workers.Molecular Genetics & Genomic Medicine.2019; e562.

DOI：10.1002/mgg3.562.

22. Hengdong Zhang, Ming Xu, Qiuni Zhao, Kai Sun, Wei Gong, Qiaoyun Zhang, Baoli Zhu,Yan An. Association between Polymorphism of Exportin-5 and Susceptibility to Lead Poisoning in a Chinese Population.International Journal of Environmental Research and Public Health.2017, 14, 36.

DOI:10.3390/ijerph14010036

21. Dapeng Wang; Yasuyo Shimoda; Sanxiang Wang; Zhenghui Wang; Jian Liu; Xing Liu; Huanyu Jin; Fenfang Gao; Jian Tong; Kenzo Yamanaka; Jie Zhang;Yan An. Total Arsenic and Speciation Analysis of Saliva and Urine Samples from Individuals Living in Chronic Arsenicosis Area in China.Environmental Health and Preventive Medicine.2017, 22:45.

DOI:10.1186/s12199-017-0652-5

20. Xing Liu; Bin Sun; Xiaojuan Wang; Jihua Nie; Zhihai Chen;Yan An; Jian Tong. Synergistic Effect of Radon and Sodium Arsenite on DNA Damage in HBE Cells.Environmental Toxicology and Pharmacology.2016,41: 127-131.

DOI: 10.1016/j.etap.2015.11.013

19. Dapeng Wang; Yuan Ma; Xu Yang; Xiguo Xu; Yingying Zhao; Zhen Zhu; Xiaojuan Wang; Hanyi Deng; Chunchun Li; Fenfang Gao; Jian Tong; Kenzo Yamanaka;Yan An. Hypermethylation of Keap1 Gene Inactivates Its Function and Promotes Nrf2 Nuclear Accumulation Is Involved in Arsenite-Induced Human Keratinocyte Transformation.Free Radical Biology and Medicine.2015,89:209-219.

DOI：10.1016/j.freeradbiomed.2015.07.153

18. Xu Yang; Dapeng Wang; Yuan Ma; Xiguo Xu; Yingying Zhao; Zhen Zhu; Xiaojuan Wang; Hanyi Deng; Chunchun Li; Fenfang Gao; Jian Tong; Kenzo Yamanaka;Yan An. Continuous Activation of Nrf2 and Its Target Antioxidant Enzymes Leads to Arsenite-Induced Malignant Transformation of Human Bronchial Epithelial Cells.Toxicology and Applied Pharmacology.2015, 289:231-239.

DOI: 10.1016/j.taap.2015.09.020

17. Zhen Zhu, Dapeng Wang,Yuan Ma, Xu Yang, Xiaojuan Wang, Hua Yin,Yan An. Optimization of antioxidant silk fibroin peptide hydrolysis process.Advanced Materials Research.2015,1073-1076:1789-1792(EI).

16. Zhen Zhu, Hua Yin,Yan An. Antioxidant activity of silk fibroin peptide hydrolyzed by pancreatin.Advanced Materials Research.2015,1081:110-114(EI).

15. Dapeng Wang, Yasuyo Shimoda, Hidetoshi Kurosawa, Jian Liu, Xiguo Xu, Xing Liu, Huanyu Jin, Jian Tong, Kenzo Yamanaka,Yan An. Excretion Patterns of Arsenic and Its Metabolites in Human Saliva and Urine After Ingestion of Chinese Seaweed.International Journal of Environmental Analytical Chemistry.2015, 95(5):379-389.

DOI: 10.1080/03067319.2015.10368608

14. Huanyu Jin, Xing Liu, Hua Yin,Yan An. The application of silk fibroin in tissue engineering and drug carrier area.Advanced Materials Research.2013,634-638：1120-1123(EI).

13. Huanyu Jin, Hua Yin,Yan An. The effect of gamma ray on the thermo-mechanical property of silk fibroin.Thermal Science.2013, 17(5): 1521-1522.

DOI: 102298/TSCI1305521J#

12. Huanyu Jin, Yu Liu, Xing Liu, Dapeng Wang, Jian Liu, Hua Yin,Yan An. Study on biocompatibility of post-irradiated silk fibroin in vitro.Advanced Materials Research.2012,535-537:2357-2360(EI).

11. Huanyu Jin, Yu Liu, Xing Liu, Dapeng Wang, Jian Liu,Hemei Zhang, Chunyan Zong, Hua Zhao, Xiaoqing Feng, Hua Yin,Yan An. Effect of gamma irradiation on the biocompatibility and biodegradation of silk fibroin in vivo.Advanced Materials Research.2012,535-537:2361-2364(EI).

10. Huanyu Jin，Hua Yin，Yu Liu，Yan An. The effect of gamma ray on the mechanical and molecular structure changes of silk fibroin.Advanced Material Research.2012,502: 269-272(EI).

9. Dapeng Wang, Sanxiang Wang, Zhenghui Wang, Liming Zhang, Jian Li, Jian Liu, Xing Liu, Huanyu Jin, Chunling Fu,Yan An. The arsenic concentration in saliva, urine and drinking water in endemic arsenicosis area in Shanyin county of Shanxi province, China.Applied Mechanics and Materials.2012,140:465-468(EI).

8. Dapeng Wang, Liming Zhang, Jian Li, Jian Liu, Xing Liu, Huanyu Jin, Chunyan Ji, Chunling Fu,Yan An. Comparison of the total arsenic between urine and saliva after consumption of seafood among volunteers.Conference on Environmental Pollution and Public Health.2011, 271-273(ISTP).

7. Chunyan Ji, Chunling Fu, Quanyong Xiang, Song Xu, Mingqing Zhu, Jian Liu, Dapeng Wang, Jie Zhang,Yan An. Biomarkers of early vascular endothelial injury with low-arsenic exposure in drinking water of Jiangsu province.Conference on Environmental Pollution and Public Health2011, 364-366.(ISTP).

6. Huanyu Jin, Hua Yin,Yan An. The application of radiation technology in the field of medical biomaterials.Advanced Material Research.2011,287-290:1929-1932(EI).

5. JianLiu, Sanxiang Wang, Zhenghui Wang, Dapeng Wang, Zhen Li, Xiaoping Wang, Xing Liu, Huanyu Jin,Yan An. The Relationship between Arseninc Exposure and Skin Lesions in Endemic Arsenicosis Area of Shanxi Province, China. 2011 International Conference on Human Health and Biomedical Engineering.2011,7:1198-1200(EI).

4. Dapeng Wang, Liming Zhang, Jian Li, Jian Liu, Xing Liu, Huanyu Jin, Chunyan Ji, Chunling Fu,Yan An. Disposition of arsenic in saliva, blood and urine of Sprague-Dawley rats following repeated oral exposure to sodium arsenite.2011 International Conference on Human Health and Biomedical Engineering.2011,6：1156-1159(EI).

3. Jian Liu, Sanxiang Wang, Zhenghui Wang, Dapeng Wang, Zhen Li, Xiaoping Wang, Xing Liu, Huanyu Jin, Yoko Endo, Ginji Endo, Kenzo Yamanaka,Yan An. The level of aseninc in environmental media in endemic arsenism area of Shanxi province, China.Conference on Environmental Pollution and Public Health.2011, 301-304.(ISTP).

2.Yan An*, Koichi Kato , Masayuki Nakano, Hiroshi Otsu, Shoji Okada, Kenzo Yamanaka. Specific induction of oxidative stress in terminal bronchiolar Clara cells during dimethylarsenic-induced lung tumor promoting process in mice.Cancer Letters.2005, 230(1): 57-64.

DOI:10.1016/j.canlet.2004.12.029

1.Yan An*, Zenglin Gao, Zhongwen Wang, Shaohe Yang, Jianfen Liang, Yan Feng, Koichi Kato, Masayuki Nakano, Shoji Okada, Kenzo Yamanaka. Immunohistochemical analysis of oxidative DNA damage in arsenic-related human skin samples from arsenic-contaminated area of China.Cancer Letters.2004, 214(1): 11-18.

DOI:10.1016/j.canlet.2004.04.005

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