苗庆庆,教授、博士生导师
电话:0512-65880052传真:0512-65884380
电子邮箱:qqmiao@suda.edu.cn
通讯地址:苏州工业园区仁爱路199号,邮编215123
个人简历:
苗庆庆,www.优德88.cpm 放射医学与防护学院特聘教授,博士生导师,国家重大人才工程A类青年项目入选者,江苏特聘教授,江苏省双创博士人才项目,主持国家自然科学基金青年基金,江苏省青年基金各1项。2010年获得安徽大学化学专业学士学位,2015年获得中国科学技术大学分析化学专业博士学位。2015年至2018年在新加坡南洋理工大学化学与生物医学工程学院完成博士后研究。2018年11月加入www.优德88.cpm 放射医学与防护学院分子影像与核医学研究中心。主要从事发展核医学探针、光学探针、纳米技术等用于疾病诊断、治疗及精准医学等的研究。研究领域涉及分子影像,纳米医学,转化医学等交叉领域。迄今为止在Nature Biotechnology, Angewandte Chemie International Edition, Advanced Materials等国际核心学术期刊上发表研究论文30多篇。
研究方向:
1.放射性核素探针的设计、合成及其在重大疾病早期诊断、高效治疗等方面的应用基础研究:针对肿瘤高特性靶点和普适性肿瘤微环境开发高性能核素探针;通过合理调控探针的结构,亲疏水性,分子量,自组装等性能参数,调控核素探针的体内行为,提高探针诊疗效果;
2.高灵敏、高特异性探针设计及生物医学应用:针对生物蛋白酶、pH、ROS等与生命活动相关的生物标志物设计激活光学探针,用于肿瘤等疾病的早期诊断。
科研项目:
1. 姑苏创新创业青年领军人才,2021.1-2023.12,50万,主持
2. 国家重大人才工程A类青年项目,2020.1-2022.12,200万,主持
3. 国家自然科学基金青年项目,81901803,2020.1-2022.12,21万,主持
4. 2019江苏特聘教授,2019.9-2022.8,100万,主持
5. 江苏省青年基金项目,2019.7-2022.6,BK20190811, 20万,主持
代表性论著:
1.Yuan Zhang#, Guanglin Wang#, Qing Li*, Yue Jiang, Wan Chen, Min Zhao, Gaoling Liang,Qingqing Miao*,Acidity-Activated Charge Conversion of177Lu-labeled Nanoagent for the Enhanced Photodynamic Radionuclide Therapy of Cancer.ACS Appl. Mater. Interfaces,2022, 14, 3875-3884.
2. Yan Zhang#,*, Shasha He#, Wan Chen, Yinghua Liu, Xuefei Zhang,Qingqing Miao*, Kanyi Pu*. Activatable Polymeric Nanoprobe for Near‐Infrared Fluorescence and Photoacoustic Imaging of T Lymphocytes.Angew. Chem. Int. Ed.,2021, 60, 5921-5927.
3. Wu Cai#, Guohua Fan#, Hui Zhou#, Lei Chen, Jianxian Ge, Baoxing Huang, Dandan Zhou, Jianfeng Zeng*,Qingqing Miao*, Chunhong Hu*. Self-Assembled Hybrid Nanocomposites for Multimodal Imaging-Guided Photothermal Therapy of Lymph Node Metastasis. W Cai, G Fan, H Zhou, L Chen, J Ge, B Huang, D Zhou, J Zeng, Q Miao.ACS Appl. Mater. Interfaces,2020, 12, 49407-49415.
4. Qing Li#, Shenhua Li#, Shasha He, Wan Chen, Penghui Cheng, Yan Zhang,Qingqing Miao*, and Kanyi Pu*.An Activatable Polymeric Reporter for Near-Infrared Fluorescent and Photoacoustic Imaging of Invasive Cancer.Angew. Chem. Int. Ed.,2020, 59, 7018 – 7023 (Cover).
5.Qing Li, Jianfeng Zeng,Qingqing Miao* and Mingyuan Gao. Self-Illuminating Agents for Deep-Tissue Optical Imaging.Front. Bioeng. Biotechnol.2019, 7, 326.
6.Qingqing Miao, and Kanyi Pu*.Organic Semiconducting Agents for Deep‐Tissue Molecular Imaging: Second Near‐Infrared Fluorescence, Self‐Luminescence, and Photoacoustics.Adv. Mater.,2018, 30, 1801778.
7.Qingqing Miao#, David C. Yeo#, Christian Wiraja, Jianjian Zhang, Xiaoyu Ning, Chenjie Xu,* and Kanyi Pu*. Near‐Infrared Fluorescent Molecular Probe for Sensitive Imaging of Keloid.Angew. Chem. Int. Ed.,2018, 57, 1256 –1260.
8.Qingqing Miao, Chen Xie, Xu Zhen, Yan Lyu, Hongwei Duan, Xiaogang Liu, Jesse V Jokerst, and Kanyi Pu*. Molecular afterglow imaging with bright, biodegradable polymer nanoparticles.Nat. Biotechnol.,2017, 35, 1102.
9.Qingqing Miao#, Yan Lyu#, Dan Ding and Kanyi Pu*. Semiconducting oligomer nanoparticles as an activatable photoacoustic probe with amplified brightness for in vivo imaging of pH.Adv. Mater.,2016, 28, 3662-3668.
10.Qingqing Miao, and Kanyi Pu*.Emerging designs of activatable photoacoustic probes for molecular imaging.Bioconjugate Chem., 2016, 27, 2808-2823.
11.Qingqing Miao, Qing Li, Qingpan Yuan, Lingli Li, Zijuan Hai, Shuang Liu, and Gaolin Liang*.Discriminative fluorescence sensing of biothiols in vitro and in living cells.Anal. Chem.,2015, 87, 3460-3466.
12.Qingqing Miao, ZiyeWu, Zijuan Hai, Changlu Tao, Qingpan Yuan, Yadi Gong, Yafeng Guan, Jun Jiang* and Gaolin Liang*.Bipyridine hydrogel for selective and visible detection and absorption of Cd2+.Nanoscale,2015, 7, 2797-2804.
13.Qingqing Miao, Chunying Yin, Maolin Xie, Yufeng Luo, Zijuan Hai, Qingpan Yuan, Jun Jiang and Gaolin Liang*.Gathering nanorings via Fe2+–bipyridine coordination.Chem. Commun.,2015, 51, 11045-11047.
专利
1. Polymer nanoparticles for afterglow molecular imaging, US Patent App. 16/633,887, 2021.
2.一种可激活光学分子探针及其制备方法与应用,专利号,ZL 2020 1 0081216.0;
3.一种可区分检测生物硫醇的荧光探针及其制备方法,专利号:ZL 2015 1 0016547.5;
4.一种可检测和去除镉的超分子水凝胶凝胶因子及其制法,专利号:ZL 2014 1 0636033.5;
5.一种单光子发射计算机断层成像显像剂及其制备方法,专利号:ZL 2012 1 0164547.6。
荣誉奖励:
1.海外高层次人才,2020
2.江苏省特聘教授,2019
3.江苏省双创博士,2019
课程教学及招生信息
本课题组热忱欢迎有志从事科研工作的本科/硕士/博士研究生以及博士后到课题组学习工作。欢迎具有化学、生物和医学背景的同学加盟。如有兴趣,请联系qqmiao@suda.edu.cn。诚挚欢迎各位加入我们课题组!