葛翠翠,特聘教授、博士生导师

话:0512-65882263箱:ccge@suda.edu.cn

通讯地址:苏州工业园区仁爱路199,邮编215123

个人简历:

葛翠翠博士,2005年毕业于安徽师范大学获得理学学士学位;2011年获得中科院高能物理研究所博士理学学位,2012年入职www.优德88.cpm 放射医学与防护学院并组建课题组,并聘为副教授。202010月起被聘为特聘教授。

研究方向

1.探索纳米-蛋白质界面作用的规律研究界面作用对重要功能蛋白构象功能的影响以及功能蛋白质活性的抑制或增强效应,准确揭示纳米材料的生物效应机制,探索和开发纳米材料在相关疾病治疗中的潜在应用。

2.聚焦纳米酶研究领域的关键瓶颈问题,为有效提高纳米酶活性提供重要解决策略基于纳米酶在肿瘤催化治疗中的优势及其独特的抗菌机制,推动发展纳米酶在肿瘤治疗、抗菌感染治疗领域的潜在应用

主持科研项目(课题)

1.国家自然科学基金委优秀青年科学基金项目,纳米环境健康效应。

2.国家科学技术部国家重点基础研究发展计划,2020YFA0710700-02生物界面蛋白质主动精准调控与高效递送载体构建子课题

3.江苏省高等学校自然www.优德88.cpm 重大项目,19KJA610003纳米酶在放疗联合维生素C抗肿瘤治疗中的潜在应用。

4.国家自然科学基金面上项目,11575124,先进同步辐射技术用于金纳米材料与典型蛋白质相互作用及相关生物效应研究

5.国家科学技术部国家重点基础研究发展计划,2014CB931900,核酸药物高效纳米载药系统的研究子课题。

代表性论著:

1.Chong, Yu; Liu, Qiang;Ge, Cuicui*.Advances in oxidase-mimicking nanozymes: Classification, activity regulation and biomedical applications. Nano Today, 2021,37:101076.

2.Proteasome activity regulated by charged gold nanoclusters: Implications for neurodegenerative diseases. Ma,Xiaochuan;Lee,Sangyun;Fei,Xingshu;Fang,Ge;HuynhTien;Chen,Chunying;Chai,Zhifang;Ge, Cuicui*;Zhou,Ruhong*. Nano Today, 2020, 35:100933.

3.Cai, Tingting#; Fang, Ge#; Tian, Xin; Yin, Jun-Jie; Chen, Chunying; Ge, Cuicui*; Optimization of antibacterial efficacy of noble-metal-based core-shell nanostructures and effect of natural organic matter,ACS Nano, 2019, 13(11): 12694-12702.

4.Wu, Renfei#; Chong, Yu#; Fang, Ge; Jiang, Xiumei; Pan, Yue; Chen, Chunying; Yin, Jun-Jie;Ge, Cuicui*; Synthesis of Pt hollow nanodendrites with enhanced peroxidase-like activity against bacterial infections: implication for wound healing,Advanced Functional Materials, 2018, 28(28): 1801484.

5.Fang, Ge#; Li, Weifeng#; Shen, Xiaomei; Perez-Aguilar, Jose Manuel; Chong, Yu; Gao, Xingfa; Chai, Zhifang; Chen, Chunying*;Ge, Cuicui*; Zhou, Ruhong*;Differential Pd-nanocrystal facets demonstrate distinct antibacterial activity against Gram-positive and Gram-negative bacteria,Nature Communications, 2018, 9: 129.

6.Chong, Yu#; Dai, Xing#; Fang, Ge; Wu, Renfei; Zhao, Lin; Ma, Xiaochuan; Tian, Xin; Lee, Sangyun; Zhang, Chao; Chen, Chunying; Chai, Zhifang;Ge, Cuicui*; Zhou, Ruhong*;Palladium concave nanocrystals with high-index facets accelerate ascorbate oxidation in cancer treatment,Nature Communications, 2018, 9: 4861.

7.Tian, Xin#; Yang, Zaixing#; Duan, Guangxin#; Wu, Anqing; Gu, Zonglin; Zhang, Leili; Chen, Chunying; Chai, Zhifang;Ge, Cuicui*; Zhou, Ruhong*;Graphene oxide nanosheets retard cellular migration via disruption of actin cytoskeleton.,Small, 2017, 13(3): 1602133.

8.Cheng, Xiaju#; Yong, Yuan#; Dai, Yiheng; Song, Xin; Yang, Gang; Pan, Yue*;Ge, Cuicui*; Enhanced radiotherapy using bismuth sulfide nanoagents combined with photo-thermal treatment,Theranostics, 2017, 7(17): 4087-4098.

9.Chong, Yu;Ge, Cuicui*; Fang, Ge; Tian, Xin; Ma, Xiaochuan; Wen, Tao; Wamer, Wayne G.; Chen, Chunying*; Chai, Zhifang; Yin, Jun-Jie*; Crossover between anti- and pro-oxidant activities of graphene quantum dots in the absence or presence of light,ACS Nano, 2016, 10(9): 8690-8699.

10.Cheng, Xiaju#; Tian, Xin#; Wu, Anqing; Li, Jianxiang*; Tian, Jian; Chong, Yu; Chai, Zhifang; Zhao, Yuliang; Chen, Chunying;Ge, Cuicui*; Protein corona influences cellular uptake of gold nanoparticles by phagocytic and nonphagocytic cells in a size-dependent manner,ACS Applied Materials & Interfaces, 2015, 7(37): 20568-20575.

11.Ge, Cuicui#; Du, Jiangfeng#; Zhao, Lina; Wang, Liming; Liu, Ying; Li, Denghua; Yang, Yanlian; Zhou, Ruhong*; Zhao, Yuliang*; Chai, Zhifang; Chen, Chunying*; Binding of blood proteins to carbon nanotubes reduces cytotoxicity.,Proceedings of the National Academy of Sciences of the United States of America, 2011, 108(41): 16968-16973.

课程教学及招生信息:

本课题组长期招收化学,生物及医学类的优秀研究生,博士生。欢迎对本课题组研究方向感兴趣的优秀人才加入,申请科研助理,博士后,助理研究员,副教授等职位。