周光明，教授、博士生导师

电话：0512-65884829传真：0512-65884380

电子邮箱：gmzhou@suda.edu.cn
通讯地址：苏州工业园区仁爱路199号,邮编215123

个人简历：

周光明教授，www.优德88.cpm放射医学与防护学院教授，博士生导师，现任放医学院副院长。2002-2003在日本千叶大学放射研究所做访问学者，2003-2007年在美国纽约布鲁克海文国家实验室生物系和美国哥伦比亚大学辐射研究中心开展博士后工作。长期从事重离子放射治疗肿瘤的生物医学基础研究和空间辐射生物效应及其机理研究。2008年入选中国科学院“百人计划”暨引进国外杰出人才，2012年入选中国科学院空间辐射生物学交叉与创新团队，2016年当选江苏省放射毒理专业委员会主任委员，2018年当选国际空间委员会（COSPAR）F2组副主席，2019年当选国际宇航科学院通讯院士。

先后主持完成科技部重点研发计划课题、973课题，国家自然科学基金重点项目、面上项目、联合项目、应急管理项目等14项。在Cancer Research、RNA Biology等国际知名刊物发表论文百余篇。授权中国发明专利8项。

研究方向：

1.空间辐射健康风险评价与防护

2.辐射致癌的分子机理研究

3.非编码RNA的功能研究

4.粒子辐射治疗肿瘤相关的生物医学基础研究

科研项目：

1.国家重点研发计划“数字诊疗装备研发”试点专项项目“分子影像引导的乏氧肿瘤多线束精准放射治疗计划技术研发及临床实现”2018YFC0115704，课题负责人，95万元（项目经费500万元），2018年8月至2021年7月

2.预研项目“XXX”，41424060204，项目负责人，315万元，2018年11月至2020年12月

代表性论著：

  1. ZhouG. (2020) Mechanisms underlying FLASH radiotherapy, a novel way to enlarge the differential responses to ionizing radiation between normal and
tumor tissues. Radiation Medicine and Protection, 1: 35-40

  2. 胡文涛，周光明*。中国空间辐射生物研究面临的挑战和机遇。科学通报，2019，64（36）：3824-3829

  3. Hu W, Zhu L, Pei W, Pan S, Wang Z, Wu A, Pei H, Nie J, Li B, Furusawa Y, Konishi T, Hei TK*, Zhou G*. (2019) Overexpression of Ras-Related C3 Botulinum Toxin Substrate 2 Radiosensitizes Melanoma Cells In Vitro and In Vivo. Oxidative Medicine and Cellular Longevity, 1-10

  4. Mao W#, Guo Z#, Dai Y#, Nie J, Li B, Pei H*, Zhou G*. (2019) LNC CRYBG3 inhibits tumor growth by inducing M phase arrest. J Cancer, 10:2764-2770

  5. Guo Z, Pei H, Nie J, Hu W, Zhang J, Ding J, Pan S, Li B, Hei TK, Chen W*, Zhou G*. (2019) Anti-cancer effects of CQBTO, a chloroquine, and benzo(e)triazine oxide conjugate. Chem Biol Drug Des, 1-9

  6. Pei W, Hu W, Chai Z, Zhou G*. (2019) Current status of space radiobiological studies in China. Life Sciences in Space Research, 22: 1-7

  7. Zhang J, Zheng L, Wang Z, Pei H, Hu W, Nie J, Shang P, Li B, Hei TK, Zhou G*. (2019) Lowering iron level protects against bone loss in focally irradiated and contralateral femurs through distinct mechanisms. Bone 120:50-60.

  8. Hu W, Wei X, Zhu L, Yin D, Wei A, Bi X, Liu T, Zhou G, Qiang Y, Sun X, Wen Z*, Pan Y*. (2019) Enhancing proliferation and migration of fibroblast cells by electric stimulation based on triboelectric nanogenerator, Nano Energy, 57: 600-607

  9. Pei H, Hu W, Guo Z, Chen H, Ma J, Mao W, Li B, Wang A, Wan J, Zhang J, Nie J, Zhou G*, Hei TK*. (2018) Long non-coding RNA CRYBG3 blocks cytokinesis by directly binding G-actin. Cancer Res. 78:4563-4572.

  10. Chen H, Pei H, Hu W, Ma J, Zhang J, Mao W, Nie J, Xu C, Li B, Hei TK, Wang C, Zhou G*. (2018) Long non-coding RNA CRYBG3 regulates glycolysis of lung cancer cells by interacting with lactage dehydrogenase A. J. Cancer 9:2580-2588.

  11. Hu W, Pei H, Sun F, Li P, Nie J, Li B, Hei TK, Zhou G*. (2018) Epithelial mesenchymal transition in non-targeted lung tissues of Kunming mice exposed to X-rays is suppressed by celecoxib. J. Radiat. Res. 59(5):583-587.

  12. Hu W, Pei W, Zhu L, Nie J, Pei H, Zhang J, Li B, Hei TK, Zhou G*. (2018) Microarray Profiling of TGF-β1-Induced Long Non-Coding RNA Expression Patterns in Human Lung Bronchial Epithelial BEAS-2B Cells. Cell Physiol Biochem. 50(6):2071-2085.

  13. Pei H, Guo Z, Wang Z, Dai Y, Zheng L, Zhu L, Zhang J, Hu W, Nie J, Mao W, Jia X, Li B, Hei TK, Zhou G*. (2018) RAC2 promotes abnormal proliferation of quiescent cells by enhanced JUNB expression via the MAL-SRF pathway. Cell Cycle 17:1115-1123.

  14. Zhang J, Wang Z, Wu A, Nie J, Pei H, Hu W, Wang B, Shang P, Li B, Zhou G*. (2017) Differences in responses to X-ray exposure between osteoclast and osteolast cells. J Radiat Res, 58(6): 791-802

  15. Song L, Ye W, Cui Y, Lu J, Zhang Y, Ding N, Hu W, Pei H, Yue Z*, Zhou G*. (2017) Ecto-5'-nucleotidase (CD73) is a biomarker for clear cell renal carcinoma stem-like cells. Oncotarget, 8(19): 31977-31992

  16. Pei H, Zhang J, Nie J#, Ding N, Hu W, Hua J, Hirayama R, Furusawa Y, Liu C, Li B, Hei TK, Zhou G*. (2017) RAC2-P38 MAPK-dependent NADPH oxidase activity is associated with the resistance of quiescent cells to ionizing radiation. Cell Cycle, 16(1):113-122

  17. Hu W, Xu S, Yao B, Hong M, Wu X, Pei H, Chang L, Ding N, Gao X, Ye, C, Wang J, Hei TK and Zhou G*. (2014) MiR-663 inhibits radiation-induced bystander effects by targeting TGFB1 in a feedback mode. RNA Biology, 11(9): 1189-1198

  18. Pei H, Chen W, Hu W, Zhu M, Liu T, Wang J and Zhou G*. GANRA-5 protects both cultured cells and mice from various radiation types by functioning as a free radical scavenger. Free Radical Research, 48(6): 670-678 (2014)

  19. Zhang H, Sun Z, Wei W, Liu Z, Fleming J, Zhang J, Lin N, Wang M, Chen M, Xu Y, Zhou J, Li C*, Bi L*, Zhou G*. Identification of serum microRNA biomarkers for tuberculosis using RNA-seq. PLoS ONE, 9(2): e88909 (2014).

  20. Hu W, Pei H, Ding N, He J, Wang J, Furusawa Y, Hirayama R, Matsumoto Y, Liu C, Kawata T, Zhou G*. Effects of shielding on the induction of 53BP1 foci and micronuclei after Fe ion exposures. Journal of Radiation Research, 55(1): 10-16 (2014).

  21. Wang J, He J, Su F, Ding N, Hu W, Yao B, Wang W, and Zhou G*. Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation inhibition. Cell Death and Disease, 4: e699 (2013)

  22. Ye C, Zhang X, Wan J, Chang L, Bing Z, Zhang S, Li J, He J, Wang J*, Zhou G*. Long-term G2-arrested cells exposed to ionizing radiation undergo cellular senescence via slipping into the G1 phase. Cell Cycle, 12(9): 1424-1432 (2013)

  23. Wang F, Bing Z, Zhang Y, Ao B, Zhang S, Ye C, He J, Ding N, Ye W, Xiong J, Sun J, Furusawa Y, Zhou G*, and Yang L. Quantitative proteomic analysis for radiation-induced cell cycle suspension in 92-1 melanoma cell line. Journal of Radiation Research, 1-14 (2013)

  24. Chang L, Hu W, Ye C, Yao B, Song L, Wu X, Ding N, Wang J, and Zhou G*. miR-3928 activates ATR pathway by targeting dicer. RNA Biology, 9(10): 1247-1254 (2012)

  25. He J, Li J, Ye C, Zhou L, Zhu J, Wang J, Mizota A, Furusawa Y, and Zhou G*. Cell cycle suspension: A novel process lurking in G2 arrest. Cell Cycle, 10(9): 1468-1476 (2011)

  26. Wang J, Su F, Smilenov LB, Zhou L, Hu W, Ding N, and Zhou G*. Mechanisms of increased risk of tumorigenesis in Atm and Brca1 double heterozygosity. Radiation Oncology, 6:96 (2011)

  27. Ding N, Wu X, He J, Chang L, Hu W, Li W, Wang J, Wang T, and Zhou G*. Detection of Novel Human MiRNAs Responding to X-ray Irradiation. Journal of Radiation Research, 52, 425-432 (2011)

  28. Zhou G, Smilenov LB, Lieberman HB, Ludwig T, Hall EJ. Radiosensitivity to high energy iron ions is influenced by heterozygosity for ATM, RAD9 and BRCA1. Advances in Space Research, 46: 681-686 (2010)

  29. Zhou G, Bennett PV, Cutter NC, and Sutherland BM. Proton-HZE-particle sequential dual-beam exposures increase anchorage-independent growth frequencies in primary human fibroblasts. Radiation Research, 166(3): 488-94 (2006)

  30. Zhou G, Kawata T, Furusawa Y, et al. Protective effects of melatonin against low- and high-LET irradiation. Journal of Radiation Research, 47(2): 175-181 (2006)

    专利

    1.hsa-miR-185的新用途，发明专利，201010577853.3，第一发明人；

    2.用于抗辐射的药物及制备方法和应用，发明专利，201110303366.2，第一发明人；

    3.CD73作为肾透明细胞癌干细胞表面标志物的应用，发明专利，210310181801.8，第一发明人；

    4.周光明、王菊芳、徐丹、李贺。空间环境地基模拟多功能装置，发明专利，201210366523.9，第一发明人。

    课程教学及招生信息

    负责《医学放射生物学基础》（本科生）、《让我们远离肿瘤——粒子治癌》（本科生）、《放射生物与遗传学进展》（博士研究生）的授课；

    招收放射医学、分子生物学、细胞生物学、免疫学、病理学及相关专业背景的硕士研究生、博士研究生和博士后。