YIN, Lichen

Lichen Yin, Ph.D., Professor

Email:lcyin@suda.edu.cn; Tel: 0512-65882039

Academic History:

B.S., Fudan University, School of Life Sciences, 2005.7

Ph.D., Fudan University, School of Life Sciences, 2010.7

Postdoctoral research fellow, University of Illinois at Urbana-Champaign, Dept. of Materials Science and Engineering, 2010.11-2014.1

Professor, Soochow University, since 2014.1

Research Interests:

1. Polypeptide biomaterials. Investigate the synthesis and functionalization of polypeptides used as drug carriers, gene vectors, or immune-modulators; explore the biological effect and modulation of secondary structure of polypeptides.

2. Intelligent drug delivery systems. Explore the fabrication, assembly, therapeutic efficacy, and biological mechanisms of delivery systems for proteins/peptides, nucleic acids, small-molecule drugs, and gas molecules.

3. Anti-cancer and anti-inflammation therapies. Design novel nanomedicine to manipulate the immune microenvironment of inflammation and cancer; develop advanced therapeutic strategies for the treatment of tumor, inflammation (hepatitis, pancreatitis, myocardial infarction, pneumonia, ischemic stroke, osteoarthritis), and auto-immune diseases (ulcerative colitis, rheumatoid arthritis, lupus).

Research Accomplishments:

Yin’s research interests are mainly focused on the development of polymeric biomaterials and drug/gene delivery systems for the treatment of tumor, inflammation, and auto-immune diseases. He has published over 150 peer-reviewed papers with a total non-self citation of over 9000 and an H-index of 50. He holds 19 Chinese patents and 2 US patents. He is the author for the chapter of “Nanoparticles” in “Biomaterials Science, 4^thEdition” (Elsevier) and “Polymers for protein delivery” in “Encyclopedia of Nanomaterials” (Elsevierr). He co-chaired the symposium of “Design, Synthesis and Engineering of Polypeptides for Biological and Biomedical Applications” in the 258^thACS Meeting (San Diego), and served as the guest editor for the thematic issue of “Synthetic Polypeptides for Drug and Gene Delivery, and Tissue Engineering” forAdv Drug Deliver Rev. He is also the Associate Editor of Biomaterials Science (Royal Chemistry Society) and Assistant Editor of Journal of Controlled Release (Elsevier). He is awarded by the National Science Foundation for Distinguished Young Scholars and the National Science Foundation for Excellent Young Scholars, China, and is appointed as the ‘‘Distinguished Professor’’ of Jiangsu Province.

Openings:

Graduate student: We actively recruit graduate students with background in organic/polymer/materials chemistry, biomaterials, biology, and pharmaceutical science. If you are interested, please contact Prof. Lichen Yin (lcyin@suda.edu.cn) with your CV attached.

Postdoctoral research associate: We have immediate openings for 2-3 postdoctoral scientists with PhD training in polymer chemistry, biomaterials, and drug/gene delivery. Ideal candidates are expected to perform research independently and can help supervise the graduate students. Experience of basic techniques in organic/polymer synthesis, nanofabrication, cell culture, and animal experiments is preferred. To apply for the postdoctoral position, please forward your CV and contact information of three referees directly to Professor Lichen Yin at lcyin@suda.edu.cn.

Assistant/Associated Professor: We have 2 positions for assistant/associate professors in Prof. Yin’s group. Ideal candidates are expected to have background in polymer chemistry, biomaterials, nanomedicine, and drug/gene delivery. If interested, please send your CV, a brief summary of research experience along with the name and contact information of three references to Prof. Lichen Yin at lcyin@suda.edu.cn.

Selected Publications (^#co-first author, *corresponding author):

1. Xun Liu^#, Ziyin Zhao^#, Wei Li, Ningyu Liu, Qiang Yang,Lichen Yin*. Engineering nucleotidoproteins for base pairing-assisted cytosolic delivery and genome editing.Angew Chem Int Ed, 2023, in press.

2. Chenglong Ge, Junliang Zhu, Huan Ye, Yuansong Wei, Yuheng Lei, Renxiang Zhou, Ziyuan Song,Lichen Yin*. Rational Construction of Protein-mimetic Nano-switch System Based on Secondary Structure Transition of Synthetic Polypeptide.J Am Chem Soc, 2023, 145, 11206-11214.

3. Yang Zhou^#, Qiujun Liang^#, Xuejie Wu, Shanzhou Duan, Chenglong Ge, Huan Ye, Jianhui Lu, Rongying Zhu, Yongbing Chen, Fenghua Meng,Lichen Yin*. siRNA delivery against myocardial ischemia reperfusion injury mediated by reversibly camouflaged biomimetic nanocomplexes.Adv Mater, 2023, 35, 2210691.

4. Yuansong Wei, Xudong Li, Juanhui Lin, Yang Zhou, Jiandong Yang, Mengying Hou, Fan Wu, Jing Yan, Chenglong Ge, Duanmin Hu,Lichen Yin*. Oral delivery of siRNA using fluorinated, small-sized nanocapsules toward anti-inflammation treatment.Adv Mater, 2023, 35, 2206821.

5. Ziyin Zhao^#, Xun Liu^#, Mengying Hou, Renxiang Zhou, Fan Wu, Jing Yan, Wei Li, Yujia Zheng, Qinmeng Zhong,Lichen Yin*. Endocytosis-independent and Cancer-selective Cytosolic Protein DeliveryviaReversible Tagging with LAT1 substrate.Adv Mater, 2022, 34, 2110560.

6. Xun Liu^#, Ziyin Zhao^#, Fan Wu, Yongbing Chen,Lichen Yin*. Tailoring Hyperbranched Poly(β-amino ester) as a Robust and Universal Platform for Cytosolic Protein Delivery.Adv Mater, 2022, 34, 2108116.

7. Mengying Hou, Yuansong Wei, Ziyin Zhao, Wenqing Han, Renxiang Zhou, Yang Zhou, Yiran Zheng,Lichen Yin*. Immuno-Engineered Nanodecoys for the Multi-Target Anti-Inflammatory Treatment of Autoimmune Diseases.Adv Mater, 2022, 34, 2108817.

8. Jing Yan^#, Xun Liu^#, Chenglong Ge, Fan Wu, Huan Ye, Xingye Chen, Yuansong Wei, Renxiang Zhou, Shanzhou Duan, Rongying Zhu, Yiran Zheng,Lichen Yin*. Platelet pharmacytes for the hierarchical amplification of anti-tumor immunity in response to self-generated immune signals.Adv Mater, 2022, 34, 2109517.

9. Yang Zhou^#, Yekun Deng^#, Zhongmin Liu, Mengyuan Yin, Mengyin Hou, Ziyin Zhao, Xiaozhong Zhou,Lichen Yin*. Cytokine-scavenging nanodecoys reconstruct osteoclast/osteoblast balance toward the treatment of postmenopausal osteoporosis.Sci Adv, 2021, 7, eabl6432.

10. Yekun Deng^#, Yang Zhou^#, Qiujun Liang, Chenglong Ge, Jiandong Yang, Bingchen Shan, Yong Liu, Xiaozhong Zhou*,Lichen Yin*. Inflammation-Instructed Hierarchical Delivery of IL-4/miR-21 Orchestrates Osteoimmune Microenvironment Toward the Treatment of Rheumatoid Arthritis.Adv Funct Mater, 2021, 31, 2101033.

11. Jiandong Yang^#, Shanzhou Duan^#, Huan Ye, Chenglong Ge, Chunxian Piao, Yongbing Chen, Minhyung Lee,Lichen Yin*. Pro-peptide-reinforced, mucus-penetrating pulmonary siRNA delivery mitigates cytokine storm in pneumonia.Adv Funct Mater, 2021, 31, 2008960.

12. Yong Liu,Lichen Yin*.α-Amino acidN-carboxyanhydride (NCA)-derived synthetic polypeptides for nucleic acids delivery.Adv Drug Deliver Rev, 2021, 171, 139-163.

13. Xudong Li^#, Yuansong Wei^#, Yuchen Wu,Lichen Yin*. Hypoxia-instructed pro-protein therapy assisted with self-catalyzed nanozymogen.Angew Chem Int Ed, 2020, 59, 22544-22553.

14. Shixian Lv, Hojun Kim, Ziyuan Song, Feng Lin, Yingfeng Yang, Ryan Baumgartner, Kuan-Ying Tseng, Shen J. Dillon, Cecilia Leal,Lichen Yin*, Jianjun Cheng*. Unimolecular polypeptide micelles via ultra-fast polymerization ofN-carboxyanhydrides.J Am Chem Soc, 2020, 142, 8570-8574.

15. Chenglong Ge^#, Jiandong Yang^#, Shanzhou Duan, Yong Liu, Fenghua Meng,Lichen Yin*. Fluorinated α-helical polypeptides synchronize mucus permeation and cell penetration toward highly efficient pulmonary siRNA delivery against acute lung injury.Nano Lett, 2020, 20, 1738−1746.

16. Jing Yan, Qinghua Wu, Ziyin Zhao, Jianhua Wu, Huan Ye, Qiujun Liang, Zhuchao Zhou*, Mengying Hou, Xudong Li, Yong Liu*,Lichen Yin*. Light-assisted hierarchical intratumoral penetration and programmed antitumor therapy based on tumor microenvironment (TME)-amendatory and self-adaptive polymeric nanoclusters.Biomaterials, 2020, 255, 120166.

17. Yongjuan Li, Juanjuan Dang, Qiujun Liang,Lichen Yin*. Thermal-responsive carbon monoxide (CO) delivery expedites metabolic exhaustion of cancer cells toward reversal of chemotherapy resistance.ACS Cent Sci, 2019, 5, 1044−1058.

18. Yongjuan Li^#, Juanjuan Dang^#, Qiujun Liang,Lichen Yin*. Carbon monoxide (CO)-strengthened cooperative bioreductive anti-tumor therapy via mitochondrial exhaustion and hypoxia induction.Biomaterials, 2019, 209, 138-151.

19. Juanjuan Dang, Huan Ye, Yongjuan Li, Qiujun Liang, Xudong Li,Lichen Yin*. Multivalency-assisted membrane-penetrating siRNA delivery sensitizes photothermal ablation via inhibition of tumor glycolysis metabolism.Biomaterials, 2019, 223, 119463.

20. Jinhui Wang^#, Hua He^#, Xin Xu, Xiao Wang, Yongbing Chen,Lichen Yin*. Far-Red Light-Mediated Programmable Anti-Cancer Gene Delivery in Cooperation with Photodynamic Therapy.Biomaterials, 2018, 171, 72-82.

21. Shixian Lv, Yuchen Wu, Kaimin Cai, Hua He, Yongjuan Li,Min Lan, Xuesi Chen, Jianjun Cheng,Lichen Yin*. High Drug Loading and Sub-Quantitative Loading Efficiency of Polymeric Micelles Driven by Donor−Receptor Coordination Interactions.J Am Chem Soc, 2018, 140, 1235−1238.

22. Hong-Xia Wang, Ziyuan Song, Yeh-Hsing Lao, Xin Xu, Jing Gong, Du Cheng, Syandan Chakraborty, Mingqiang Li, Dangtong Huang,Lichen Yin*, Jianjun Cheng*, Kam W. Leong*. Nonviral Gene Editing via CRISPR/Cas9 Delivery by Membrane-Disruptive and Endosomolytic Helical Polypeptide.Proc Natl Acad Sci USA, 2018, 115, 4903-4908.

23. Hua He^#, Yongbing Chen^#, Yongjuan Li^#, Ziyuan Song, Yinan Zhong, Rongying Zhu, Jianjun Cheng*,Lichen Yin*. Effective and Selective Anti-Cancer Protein Delivery via All-Function-in-One Nanocarriers Coupled with Visible Light-Responsive, Reversible Protein Engineering.Adv Funct Mater,2018, 28, 1706710.

24. Hua Wang^#, Ruibo Wang^#, Kaimin Cai^#, Hua He, Yang Liu, Jonathan Yen, Zhiyu Wang, Ming Xu, Yiwen Sun, Xin Zhou, Qian Yin, Li Tang, Iwona T Dobrucki, Lawrence W Dobrucki, Eric J Chaney, Stephen A Boppart, Timothy M Fan, Stéphane Lezmi, Xuesi Chen*,Lichen Yin*, Jianjun Cheng*. Selective in vivo metabolic cell-labeling-mediated cancer targeting.Nat Chem Biol, 2017, 13, 415-424.

25. Ziyuan Song, Rachael A. Mansbach, Hua He, Kuo-Chih Shih, Ryan Baumgartner, Nan Zheng, Xiaochu Ba, Yinzhao Huang, Deepak Mani, Yun Liu, Yao Lin, Mu-Ping Nieh, Andrew L. Ferguson*,Lichen Yin*, Jianjun Cheng*. Modulation of polypeptide conformation through donor–acceptor transformation of side-chain hydrogen bonding ligands.Nat Commun, 2017, 8:92.

26. Menghua Xiong^#, Yan Bao^#, Xin Xu^#, Hua Wang, Zhiyuan Han, Zhiyu Wang, Yeqing Liu, Songyin Huang, Ziyuan Song, Jinjing Chen, Richard M. Peek,Lichen Yin*, Lin-Feng Chen*, Jianjun Cheng*. Selective killing of Helicobacter pylori with pH-responsive helix–coil conformation transitionable antimicrobial polypeptides.Proc Natl Acad Sci USA, 2017, 114, 12675-12680.

27. Menghua Xiong, Zhiyuan Han, Ziyuan Song, Jin Yu, Hanze Ying,Lichen Yin*, Jianjun Cheng*. Bacteria-Assisted Activation of Antimicrobial Polypeptides by a Random-Coil to Helix Transition.Angew Chem Int Ed,2017, 56, 10826-10829.

Full publication list:

https://scholar.google.com/citations?user=66CEhX8AAAAJ&hl=en

Edited by Juan Yang