Department of polymer science and engineering

Education

Ph.D.Sep 2001~ Jul 2006 Changchun Institute of Applied Chemistry, CAS

B. Sc.Sep 1995~ Jul 1999 Zhanjiang Normal College, Guangdong

2014.07~presentProfessor

Department of polymer science and engineering，Soochow University,JiangsuProvince,P.R.China

2010.06~2014.06Associate Professor

Department of polymer science and engineering，Soochow University,JiangsuProvince,P.R.China

2006.08~2010.05Post-PhD Research Fellow

Ottawa Health Research Institute, Eye Institute and Heart Institute, University of Ottawa, ON, Canada.

1. Functional polypeptide

2. Polymeric nanomedicine

3. Injectable hydrogels

2010~2012Research Fellowship from the Heart and Stroke Foundation (HSF) of Canada

2009.05Best Poster Presentation and a Travel Award for the Young Investigators Forum by The Canadian Institutes of Health Research (CIHR) of Canada.

2008~-2010.Research Fellowship Awardfrom the Molecular Function and Imaging Research Program at the University of Ottawa Heart Institute, with support from the Heart and Stroke Foundation (HSF) of Ontario.

1. National Natural Science Foundation (51003070), Injectable hydrogels based on collagen and functional polyester for cardiac regeneration 2011.01~2013.12

2. National Natural Science Foundation (51273137), Novel biodegradable hydrogels and microgels prepared via “tetrazole-alkene” reaction for controlled release of protein drugs, 2013.01~2016.12

3. National Natural Science Foundation (51473110), Bio-responsive reversibly crosslinked hyaluronic acid-polypeptide nanoparticles for targeted chemotherapy of breast cancer, 2015.01~2018.12

4. Scientific Research Foundation for the Returned Overseas Chinese Scholars (State Education Ministry), 2013.1-2015.12

1.P.P. Chen, M. Qiu,C. Deng*, F.H. Meng, J. Zhang, R. Cheng, and Z.Y. Zhong*, pH-Responsive Chimaeric Pepsomes Based on Asymmetric Poly(ethylene glycol)-b-Poly(L-leucine)- b-Poly(L-glutamic acid) Triblock copolymer for Efficient Loading and Active Intracellular Delivery of Doxorubicin Hydrochloride,Biomacromolecules2015, 16, 1322-1330.

2.G.H. Xu, X.L. Wang,C. Deng*, X.M. Teng, E.J. Suuronen, Z.Y. Shen*, and Z.Y. Zhong*, Injectable Biodegradable Hybrid Hydrogels based on Thiolated Collagen and Oligo(acryloyl carbonate)-Poly(ethylene glycol)-oligo(acryloyl carbonate) Copolymer for Functional Cardiac Regeneration,Acta Biomater. 2015, 15, 55-64.

3.C. Deng, J.T. Wu, R. Cheng, F.H. Meng, H.A. Klok, and Z.Y. Zhong*, Functional Polypeptide and Hybrid Materials: Precision Synthesis via α-Amino Acid N-Carboxyanhydride Polymerization and Emerging Biomedical Applications,Prog. Polym. Sci.2014, 39, 330-364.

4.Y.J. Jiang, J. Chen,C. Deng*, E.J. Suuronen, and Z.Y. Zhong*, Click Hydrogels, Microgels and Nanogels: Emerging Platforms for Drug Delivery and Tissue Engineering,Biomaterials2014, 35, 4969-4985.

5.Y.N. Zhong, F.H. Meng,C. Deng*, and Z.Y. Zhong*, Ligand-Directed Active Tumor-Targeting Polymeric Nanoparticles for Cancer Chemotherapy,Biomacromolecules2014, 15, 1955-1969.

6.W. Chen, Y. Zou, F.H. Meng, R. Cheng,C. Deng*, J. Feijen, and Z.Y. Zhong*, Glyco-Nanoparticles with Sheddable Saccharide Shells: A Unique and Potent Platform for Hepatoma-Targeting Delivery of Anticancer Drugs,Biomacromolecules2014, 15, 900-907.

7.W.W. Guo, M. Zheng, Y.N. Zhong, F.H. Meng,C. Deng*, and Z.Y. Zhong*, Poly(ethylene oxide)-graft-Methotrexate Macromolecular Drugs Conjugating via Aminopteridine Ring Exhibit Potent Anticancer Activity,Chin. J. Chem.2014, 32, 57-65.

8.L.L. Wu, Y. Zou,C. Deng*, R. Cheng, F.H. Meng, and Z.Y. Zhong*, Intracellular Release of Doxorubicin from Core-Crosslinked Polypeptide Micelles Triggered by Both pH and Reduction Conditions,Biomaterials2013, 34, 5262-5272.

9.J.R. Zhou, P.P. Chen,C. Deng*, F.H. Meng, R. Cheng, and Z.Y. Zhong*, A Simple and Versatile Synthetic Strategy to Functional Polypeptides via Vinyl Sulfone-Substituted L-Cysteine N-Carboxyanhydride,Macromolecules2013, 46, 6723–6730.

10.Y.N. Zhong, W.J. Yang, H.L. Sun, R. Cheng, F.H. Meng,C. Deng*, and Z.Y. Zhong*, Ligand-Directed Reduction-Sensitive Shell-Sheddable Biodegradable Micelles Actively Deliver Doxorubicin into the Nuclei of Target Cancer Cells,Biomacromolecules2013, 14, 3723-3730.

11.Y.P. Fan,C. Deng*, R. Cheng, F.H. Meng, and Z.Y. Zhong*, In Situ Forming Hydrogels via Catalyst-Free and Bioorthogonal “Tetrazole–Alkene” Photo-Click Chemistry,Biomacromolecules2013, 14, 2814-2821.

12.C. Deng, Y.J. Jiang, R. Cheng, F.H. Meng, and Z.Y. Zhong*, Biodegradable Polymeric Micelles for Targeted and Controlled Anticancer Drug Delivery: Promises, Progress and Prospects,Nano Today2012, 7, 467-480.

13.Y.X. Yu,C. Deng, F.H. Meng, Q. Shi, J. Feijen, and Z.Y. Zhong*, Novel Injectable Biodegradable Glycol Chitosan-Based Hydrogels Crosslinked by Michael-Type Addition Reaction with Oligo(acryloyl carbonate)-b-Poly(ethylene glycol)-b- ligo(acryloyl carbonate) Copolymers,J. Biomed. Mater. Res. Part A2011, 99A, 316-326.

14.C. Deng, P. Zhang, B. Vulesevic, D. Kuraitis, F. Li, A.F. Yang, M. Griffith, M. Ruel, and E.J. Suuronen*, A Collagen-Chitosan Hydrogel for Endothelial Differentiation and Angiogenesis,Tissue Eng. Part A2010, 16, 3099-3109.

15.C. Deng, F.F. Li*, J.M. Hackett, S.H. Chaudhry, F.N. Toll, B. Toye, W. Hodge, and M. Griffith*, Collagen and Glycopolymer Based Hydrogel for Potential Corneal Application,Acta Biomater.2010, 6, 187-94.

16.W.G Liu,C. Deng (co-first author), C.R. McLaughlin, P. Fagerholm, N.S. Lagali, B. Heyne, J.C. Scaiano, M.A. Watsky, Y. Kato, R. Munger, N. Shinozaki, F.F. Li, and M. Griffith*, Collagen-Phosphorylcholine Interpenetrating Network Hydrogels as Corneal Substitutes,Biomaterials2009, 30, 1551-1559.