Education Background:

1991-1995Henan Normal University, B.Sc.

1995-2001Shanghai Institute of Plant Physiology & Ecology, Chinese Academy of Sciences, Ph.D.

2001-2003Johns Hopkins University, USA, Postdoc.

2003-2010Wuhan University of Technology, Associate Professor.

2010-Soochow University, Professor.

Research Interests:

Synthesis and biological activities of functional nanomaterials;

Molecular recognition of cell – polymer surface in the biointerface;

Bio-function induction by polymer surfaces.

Recent Publications：

1.Feng Liu, Yuecheng Cui, Lei Wang, Hongwei Wang*, Yuqi Yuan, Jingjing Pan, Hong Chen,Lin Yuan*. Temperature-responsive poly(N-isopropylacrylamide) modified gold nanoparticle-protein conjugates for bioactivity modulation.ACS Applied Materials & Interfaces,2015, DOI: 10.1021/acsami.5b02502.

2.Lei Wang, Xin Li,Lin Yuan,* Hongwei Wang, Hong Chen*, John L. Brash. Improving the protein activity and stability under acidic conditions via site-specific conjugation of a pH-responsive polyelectrolyte.Journal of Materials ChemistryB,2015, 3, 498-504.

3. Feng Liu, Lei Wang, Hongwei Wang,Lin Yuan*, Jingwen Li, John Law Brash, Hong Chen*. Modulating the activity of protein conjugated to gold nanoparticles by site-directed orientation and surface density of bound protein.ACS Applied Materials & Interfaces,2015, 7, 3717-3724.

4. Wenwen Jiang, Xiaoli Liu, Di Wu, Hongwei Wang*, Yanwei Wang, Hong Chen,Lin Yuan*. A simple, rapid one-step ELISA using antibody–antibody complex.Biotechnology and Applied Biochemistry, 2015, 62, 126-131.

5. Zhonglin Lyu, Hongwei Wang, Yanyun Wang, Kaiguo Ding, Huan Liu,Lin Yuan*, Xiujuan Shi, Mengmeng Wang, Yanwei Wang, Hong Chen*. Maintaining the pluripotency of mouse embryonic stem cells on gold nanoparticle layers with nanoscale but not microscale surface roughness.Nanoscale,2014,6,6959-6969.

6. Min Tan, Hongwei Wang,* Yanyun Wang, Gaojian Chen,Lin Yuan*, Hong Chen. Recyclable antibacterial material: silicon grafted with 3,6-O-sulfated chitosan and specifically bound by lysozyme.Journal of Materials ChemistryB,2014, 2, 569-576.

7. Xuejiao Du, Yanyun Wang,Lin Yuan,*Yuyan Weng, Gaojian Chen,*Zhijun Hu*. Guiding the behaviors of human umbilical vein endothelial cellswith patterned silk fibroin films.Colloids and Surfaces B: Biointerfaces,2014, 122, 79-84.

8. Jingjing Pan, Zhonglin Lyu, Wenwen Jiang, Hongwei Wang*, Qi Liu, Min Tan,Lin Yuan*, Hong Chen. Stimulation of gene transfection by silicon nanowire arrays modified with polyethylenimine.ACS Applied Materials & Interfaces,2014, 6, 14391-14398.

9. Kaiguo Ding, Yanyun Wang, Hongwei Wang,Lin Yuan*, Min Tan, Xiujuan Shi, Zhonglin Lyu, Yan Liu, Hong Chen*. 6-O-sulfated chitosan promoting the neural differentiation of mouse embryonic stem cells.ACS Applied Materials & Interfaces,2014, DOI: 10.1021/am505628g.

10. Hongwei Wang, Yanwei Wang,Lin Yuan*, Lei Wang, Weikang Yang, Zhaoqiang Wu, Dan Li, Hong Chen*. Thermally responsive silicon nanowire arrays for native/denatured protein separation.Nanotechnology, 2013, 24, 105101.

11. Hongwei Wang, Wenwen Jiang,Lin Yuan*, Lei Wang, Hong Chen*. Reductase-like activity of silicon nanowire arrays.ACS Applied Materials & Interfaces,2013,5, 1800-1805.

12. Yajun Xu, Lei Wang, Wenwen Jiang, Hongwei Wang*, Jianlin Yao, Qinghua Guo,Lin Yuan*,Hong Chen. Silicon nanowire arrays - A new catalyst for the reduction of nitrobenzene derivatives.ChemCatChem,2013, 5, 3788 - 3793.

13. Hongwei Wang, Lei Wang,Lin Yuan*, Weikang Yang, John L Brash, Hong Chen*. Inhibitory effect of silicon nanowires on the polymerase chain reaction.Nanotechnology, 2012, 23, 365101.

14. Xiujuan Shi, Yanyun Wang, Dan Li,Lin Yuan*, Feng Zhou, Yanwei Wang, Bo Song, Zhaoqiang Wu, Hong Chen*, John L. Brash. Cell adhesion on a POEGMA-modified topographical surface.Langmuir,2012,28, 17011-17018.

15. Feng Zhou, Dan Li, Zhaoqiang Wu, Bo Song,Lin Yuan*, Hong Chen*. Enhancing specific binding of L929 fibroblasts: Effects of multi-scale topography of GRGDY peptide modified surfaces.Macromolecular Bioscience,2012, 12, 1391-1400.

16. Feng Zhou,Lin Yuan*, Dan Li, He Huang, Taolei Sun, Hong Chen*. Cell adhesion on chiral surface: The role of protein adsorption.Colloids and Surfaces. B, Biointerfaces,2012, 90, 97-101.

17. Feng Zhou, Mengmeng Wang,Lin Yuan*, Zhenping Cheng, Zhaoqiang Wu, Hong Chen*. Sensitive sandwich ELISA based on gold nanoparticle layer for cancer detection.Analyst, 2012, 137, 1779-1784.

18. Hongwei Wang,Lin Yuan*, Tieliang Zhao, He Huang, Hong Chen*. Altered enzymatic activity of lysozymes bound to variously sulfated chitosans.Chinese Journal of Polymer Science, 2012, 30, 893-899.

19.Lin Yuan, Hongwei Wang, Qian Yu, Zhaoqiang Wu, John L. Brash, Hong Chen*. “Nano-catalyst” for DNA transformation.Journal of Materials Chemistry ,2011, 21, 6148-6151.

20. Lei Wang, Hongwei Wang,Lin Yuan*, Weikang Yang, Zhaoqiang Wu and Hong Chen*. Step-wise control of protein adsorption and bacterial attachment on a nanowire array surface: tuning surface wettability by salt concentration.Journal of Materials Chemistry,2011, 21, 13920-13925.

21. Feng Zhou,Lin Yuan*, Hongwei Wang, Dan Li, Hong Chen*. Gold nanoparticle layer: a promising platform for ultra-sensitive cancer detection.Langmuir, 2011, 27, 2155-2158.

22.Lin Yuan,Qian Yu, Dan Li, Hong Chen*. Surface modification to control protein/surface interactions.Macromolecular Bioscience,2011, 8, 1031-1040.

23. Feng Zhou,Lin Yuan*, Mei Yan, Hong Chen. Effects of contact guidance and gravity on L929 cell orientation.Chinese Science Bulletin, 2011, 56, 977-981.

24. Qian Yu, Xin Li, Yanxia Zhang,Lin Yuan*, Tieliang Zhao, Hong Chen*. The synergistic effects of stimuli-responsive polymers with nano- structured surfaces: wettability and protein adsorption.RSC Advances,2011, 1, 262-269.