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CAI Zhongjian

Name：CAI Zhongjian
Title：Associate Professor

Email:zjcai@suda.edu.cn


Professor (Organic Chemistry)

B.Sc. Nanchang University (2011)

Ph.D.Soochow University(2016)

Postdoc,Shanghai Institute of Organic Chemistry (SIOC),Chinese Academy ofSciences(2016-2018)

Postdoc,Purdue University(2018-2019)

Research Interests:asymmetric C-H functionalizations; free-radical cascade reactions; synthesis of biologically active heterocycles; late-stage modification of nature products and biologically active molecules.

Representative Publications

  1. Z.-J. Cai,C.-X. Liu, Q. Wang, Q. Gu, and S.-L. You*Thioketone-DirectedRhodium(I) Catalyzed Enantioselective C-H Bond Arylationof Ferrocenes.Nature Communications2019,10,4168.

  2. Z.-J. Cai,C.-X. Liu, Q. Gu*, C. Zheng, and S.-L. You*Pd(II)-Catalyzed Regio- and Enantioselective Oxidative C-H/C-H Cross-Coupling Reaction between Ferrocenes and Azoles.Angew. Chem., Int. Ed.2019,58, 2149-2153.

  3. Z.-J. Cai,C.-X. Liu, Q. Gu, and S.-L. You*Thioketone Directed Palladium(II)-Catalyzed C-H Arylation of Ferrocenes.Angew. Chem., Int. Ed.2018,57, 1296-1299.

  4. Z.-J. Cai, F.-H. Li,S.-Y. Wang*, andS.-J. Ji*Palladium-Catalyzed Cascade Arene/Alkyne Annulation: Synthesis of Fluorene-Benzoxazine Derivatives.Organic Letters,2016,18, 4810-4813.

  5. Z.-J. Cai, C. Yang,S.-Y. Wang*, andS.-J. Ji*Palladium-catalyzed highly regioselective 6-exo-digcyclization and alkenylation ofortho-ethynylanilides: the synthesis of polyene-substituted benzo[d][1,3]oxazines.Chemical Communications,2015,51, 14267-14270.

  6. Z.-J. Cai, C. Yang,S.-Y. Wang*, andS.-J. Ji*Palladium-Catalyzed Regioselective C-H Acylation of Biaryl-2-aminesThe Journal of Organic Chemistry,2015,80, 7928 -7936.

  7. Z.-J. Cai, X.-M. Lu, Y. Zi, C. Yang, L.-J. Shen, J. Li,S.-Y. Wang*, andS.-J. Ji*I2/TBPB Mediated Oxidative Reaction of N‑Tosylhydrazones with Anilines: Practical Construction of 1,4-Disubstituted 1,2,3-Triazoles under Metal-Free and Azide-Free ConditionsOrganic Letters,2014,16, 5108-5111.

  8. Z.-J. Cai, X.-M. Lu,S.-Y. Wang*, andS.-J. Ji*Copper-Catalyzed Cyclization of Oxime Acetates with 2-Benzylidenemalononitriles for Synthesis of 2‑AminonicotinonitrilesActa Chimica Sinica,2014,72, 914-919.

  9. Z.-J. Cai,S.-Y. Wang*, andS.-J. Ji*I2/TBHP-Catalyzed ChemoselectiveAmination of IndolesOrganic Letters,2013,15, 5226-52291.

  10. Z.-J. Cai,S.-Y. Wang*, andS.-J. Ji*Copper(I)iodide/ Boron Trifluoride Etherate Cocatalyzed Aerobic Dehydrogenative Reactions Applied in the Synthesis of Substituted Heteroaromatic Imidazo[1,2-a]pyridinesAdvanced Synthesis & Catalysis,2013,355, 2686-2692.

  11. Z.-J. Cai,S.-Y. Wang*, andS.-J. Ji*CuI/BF3•Et2O Co-Catalyzed Aerobic Dehydrogenative Reactions of Ketones with Benzylamines: Facile Synthesis of Substituted ImidazolesOrganic Letters,2012,14, 6068-6071.

  12. Y. Zi,Z.-J. Cai,S.-Y. Wang*, andS.-J. Ji*Synthesis of Isatins by I2/TBHP Mediated Oxidation of Indoles.Organic Letters,2014,16, 3094-3097.(Y.Z. and Z.-J.C. contributed equally).

  13. Q. Wang,Z.-J. Cai,C.-X. Liu, Q. Gu, andS.-L.You*Rhodium-Catalyzed Atroposelective C–H Arylation: Efficient Synthesis of Axially Chiral Heterobiaryls.J. Am. Chem. Soc.2019,141, 9504-9510.