Iridium-Catalyzed Ortho-Selective C-H Borylation of Aryl Ketones with Transient Imine Ligands
Min Liang1, Chuangchuang Liu1, Wenjie Ju1, Shuxiong Han1, Jingyu Zhang2（张静宇）*, and Yingsheng Zhao1,3（赵应声）*
1Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China
2College of Energy, Soochow Institute forEnergy and Materials Innovations, Soochow University,Suzhou 215006, P. R. China;
3School of Chemistry and Chemical Engineering,Henan Normal University, Xinxiang 453000, P. R. China
Org. Lett.2024, 26, 20, 4224–4228
Abstract:Ortho-selective C–H borylation of aromatic ketones has not been extensively explored. Herein, we report the iridium-catalyzed ortho-selective C–H borylation of aromatic ketones using in situ-formed imine as the ligand. Good compatibility is observed for various substituted acetophenones and other aromatic ketones, and corresponding products are obtained with medium to excellent yields.
链接：https://pubs.acs.org/doi/10.1021/acs.orglett.4c01067
