Mechanochemical reduction of alkyl and aryl halides using mesoporous zinc oxide

Zhengheng Li,Longfei Zhang,Ran Ding,Jian Wang,Du Chen,Ziye Ren,Chengqiang Ding,Kai Chen,Jialin Wang,Zhao Wang（王召）*

State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, Jiangsu Key Laboratory of Advanced Functional Polymer Design andApplication, Suzhou Key Laboratory of Macromolecular Design and PrecisionSynthesis, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

Chem. Commun.,2024,60, 6146-6149

Abstract:In this study, we propose a mechanochemical approach that combines mesoporous ZnO (m-ZnO) as a mechanoredox catalyst and silane-mediated atom transfer chemistry to achieve efficient hydrodehalogenation of organic halides. The reaction can be conducted under mild conditions without the use of a large amount of organic solvent. Substrates ranging from activated alkyl halides to unactivated aryl halides were converted to the corresponding debrominated hydrogenation products in moderate to excellent isolated yields (50–95%). In addition, m-ZnO can be recycled and reused without appreciable loss of catalytic activity.

链接：https://pubs.rsc.org/en/content/articlelanding/2024/cc/d4cc01178c