报告题目：Pd-Catalyzed Chemical Amplification (PdCCA) for Ultrasensitive BioMarker Detection

报告人：Prof. John Texter

Eastern Michigan University, USA

报告时间：2024年5月28日(星期二), 上午9:00-10:00

报告地点：www.优德88.cpm 独墅湖校区912-509

报告摘要:

A novel chemical amplification system is proposed to update the ELISA biomarker test chemistry, which has stagnated for over 50 years but remains the main detection system worldwide for biomarkers. In the initial step of this amplification process, the protein-bound Pd(2+) is reduced to Pd(0) by an amine borane to give an active Pd(0) catalyst. High-gain (107-1010) catalytic redox amplification chemistry (a tetrazolium salt and amine borane) generates an assay dye signal. We review the primary current versions of ELISA, and then discuss expected limitations and opportunities for implementing generations 1, 2, and 3 of PdCCA, including using polymerized ionic liquid (PIL) nanobeads and PIL nanozymes with detection antibodies for amplification.

报告人简介：

John Texter is Professor Emeritus of Polymer and Coating Technology at Eastern Michigan University and Managing Consultant for Strider Research Corporation. He has been Editor-in-Chief of theJournal of Dispersion Science and Technology, Associate Editor of theJournal of Nanoparticle Research, and Section Editor for Applications ofCurrent Opinion in Colloid and Interface Science. He has worked for Eastman Kodak Company in various areas of dispersion and emulsion technology and consults through Strider Research Corporation. He received his undergraduate engineering education and his PhD in Chemistry from Lehigh University, where he studied at the Zettlemoyer Center for Surface and Coatings Research. He is an experienced lecturer, inventor, editor, organizer, and technical project manager with over 250 publications including five books, 47 issued U.S. patents, and many research and review articles. He has received numerous awards and honors and is a Fellow of the American Physical Society, the American Chemical Society, the Royal Society of Chemistry, and of the Society for Imaging Science and Technology. He has served as Chairman of the ACS Division of Colloid and Surface Chemistry, Chairman of the Chemistry at Interfaces Gordon Research Conference, Chair of the Chemistry of Supramolecules and Assemblies Gordon Research Conference, and organizer of many international symposia. He is a visiting guest Chair Professor at the School of Chemistry, Chemical Engineering, and Materials Science of Soochow University and has been a visiting professor at the Colloid and Interfaces Max Planck Institute in Potsdam (Golm), at the Graduate School of Science and Technology, Kumamoto University, and at the Fachhochschule Esslingen. His research focuses on stimuli-responsive polymers, particles, and materials and the general area of dispersion science and practice.

江苏省新型高分子功能材料工程研究中心

苏州市软物质材料与新能源重点实验室

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