Fengyang Xu†Jie Liu†Jian Tian‡Linfeng Gao†Xiaju Cheng‡Yue Pan†Ziling Sun*‡（孙自玲）Xinming Li*†⊥
†State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science,Soochow University, Suzhou 215123,China
‡School of Biology and Basic Medical Science,Soochow University, Suzhou 215123,China
⊥State Key Laboratory of Molecular Engineering of Polymers,Fudan University, Shanghai 200433,China
ACS Appl. Mater. Interfaces,2016,8(44), pp 29906–29914
In this work, we reported the generation of a novel supramolecular hydrogelator from a peptide derivative which consisted of a structural motif (e.g., Fc-FF) for supramolecular self-assembly and a functional moiety (e.g., RGD) for integrin binding. Following self-assembly in water at neutral pH, this molecule first tended to form metastable spherical aggregates, which subsequently underwent a morphological transformation to form high-aspect-ratio nanostructures over 2 h when aged at room temperature. More importantly, because of the presence of nanoscale RGD clusters on the surface of nanostructures, the self-assembled nanomaterials (e.g., nanoparticles and nanofibers) can be potentially used as a biomimetic matrix for cell culture and as a vector for cell-targeting drug delivery via multivalent RGD–integrin interactions.
链接：http://pubs.acs.org/doi/abs/10.1021/acsami.6b08624
