Ru-Catalyzed selective C–H oxidative olefination with N-heteroarenes directed by pivaloyl amide

Li Zhang,^aChangpeng Chen,^aJian Han,^aZhi-Bin Huang*^a（黄志斌）and Yingsheng Zhao*^a（赵应声）

^aKey Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China

Org. Chem. Front.,2016,3, 1271-1275

A highly efficient and practical Ru-catalyzed direct C–H functionalization of indolines andN-alkylaniline with a simple pivaloyl as a directing group is developed. Broad substrate scopes with respect to N-heteroarenes and olefins are observed. The selective C7-position alkynylation for indoline also proceeds well by using inexpensive ruthenium as a catalyst, and pivaloyl as a directing group.

链接：http://pubs.rsc.org/en/Content/ArticleLanding/2016/QO/C6QO00327C#!divAbstract