报告题目：
Smart polymer nanostructures for therapy and diagnosis
报告人
:
Min-Hui LI
Curie Physical Chemistry Laboratory, Institut Curie,
26 rue d’Ulm, 75248 Paris 05, France
地点
:
独墅湖校区
907
号楼
1445
报告厅
时间
: 2012年4月10日下午14:00-15:00
欢迎感兴趣的师生踊跃参加！
报告摘要：
Synthetic amphiphilic polymers have been largely developed since last decades for the purpose of forming self-assembled polymer vesicles (polymersomes) which mimick lipid vesicles (liposomes). Polymersomes are much more stable, more robust and less permeable than liposomes due to the high molecular weight of polymers. Another interesting feature of polymersomes is that their properties can be tuned extensively by chemical design of the amphiphilic building blocks. These nanostructures are currently studied as a means of drug delivery and biomedical imaging for their ability to entrap hydrophobic molecules in the membrane and encapsulate hydrophilic ones in the inner aqueous compartment. The tailor design of smart polymersomes, i.e., stimuli-responsive polymersomes bearing a protective coat, site-specific targeting ligands and a cell-penetrating function, is state-of-the-art research in this field. The research of our group has focused, since several years, on the development of stealth and stimuli-responsive polymersomes made from amphiphilic block copolymers. We develop robust and responsive nanostructures by combining the properties of two kinds of soft materials, polymers and liquid crystals (LC). Unique polymer nanoaggregates self-assembled by amphiphilic block copolymers, which are composed of a hydrophilic PEG block and a hydrophobic liquid crystal polymer block, will be described in this talk. The responsiveness of the nano-aggregates (disassembling or morphological control) is triggered by physical stimuli via either polymer conformational change or liquid crystal phase change.
My talk consists of two parts. In the first part I will describe photo-responsive and thermal responsive polymer vesicles (polymersomes). Three systems of photo-responsive polymersomes have been developed using different molecular design. Their bursting and wrinkling can be induced by UV light illumination. For example, using a linear-linear block copolymer, a nano-actuator design, i.e. a 10 nm-thick bimorph with only one UV responsive layer made of nematic side-chain LC polymers, is used to constitute the bilayer membrane of a spherical polymersomes. The photo-actuation of the membrane creates a spontaneous curvature in the membrane and results in instantaneous polymersome bursting. The versatility of this actuator mechanism should broaden the range of applications of polymersomes in fields such as drug delivery, cosmetics and material chemistry. We have also investigated in detail the thermal-responsive properties of LC polymersomes. The structural changes of polymersomes studied by small angle neutron scattering and cryo-electron microscopy will be discussed.
In the second part, I will describe the unique self assembly structures of amphiphilic LC block copolymers. Thermotropic LC phases exhibit in the lyotropic nano-structures. The additional internal LC order in the bilayer membrane can lead to significantly deformed vesicles as a result of the delicate interplay between two- dimensional ordering and vesicle shape. The inevitable topological defects in structured vesicles of spherical topology also play an essential role in controlling the final vesicle morphology. Nano-size cylindrical micelles (nano-fibers), faceted tetrahedral vesicles, and ellipsoidal vesicles, as well as cylindrical vesicles, were observed. The tetrahedral vesicle is a particularly fascinating example of a faceted liquid-crystalline membrane, which may lead to the design of supra-molecular structures with tetrahedral symmetry and new classes of nano-carriers.
报告人简历：
李敏慧，女，博士，法国国家www.优德88.cpm 中心
主任研究员
，博士生导师。
教育简历：
1981～1986年
北京清华大学化工系高分子材料专业 学士
1986～1989年
北京清华大学化工系高分子材料专业 硕士
1989～1993年
获法国原子能署全额奖学金留学法国巴黎，
在法国原子能署Saclay中心的Léon Brillouin实验室学习研究，
居里大学（巴黎第六大学）化学及物理化学博士
1993～1994年
法国石油研究院 博士后
工作简历：
1994～1997年
法国国家科研中心研究员，任职于化学部波尔多地区Paul Pascal 研究中心， 从事液晶化学研究
1997～2011年
法国国家科研中心研究员，任职于巴黎居里研究所，从事高分子智能材料及仿生材料的研究。
2005年
博士生导师
2008～2010年
复旦大学高级访问学者（短期）, 合作者：江明院士
2011年
法国国家科研中心主任研究员
目前研究方向：
-用于可控、靶向药物释放的纳米技术
-响应性的高分子纳米囊泡
-高分子自组装
-光响应性的高分子材料
-可控高分子聚合反应
科学期刊发表文章数目
: 53
；
H-factor = 21
，
引用次数：
1050
Proc. Natl.
Acad. Sci. U. S. A.:
1;
J. Am.
Chem. Soc.:
2
Phys.
Rev. Lett.:
2;
Adv. Mater.:2
Chem. Commun.:
2;
Soft Matter:7
Macromolecules:
8;
Phy. Rev. E:
3
高分子科学与工程系
材料与化学化工学部
