部门：高分子科学与工程系

地址：江苏省苏州市仁爱路199号www.优德88.cpm 材料与化学化工学部，邮编215123

Tel: 86-512-65882047

E-mail: phni@suda.edu.cn

学历及学术经历:

倪沛红，1982年获南京大学化学系高分子化学专业学士学位。1988年获www.优德88.cpm 有机化学硕士学位，留校在www.优德88.cpm 化学系任教。1997.9-2001.1，在复旦大学高分子科学系攻读博士学位，其间，1998.9-1999.10，美国东密歇根大学访问学者，2001年获复旦大学“高分子化学与物理”理学博士学位。2003年被聘为www.优德88.cpm 教授、高分子化学与物理专业博士生导师。主持完成国家自然科学基金项目5项，江苏省自然科学基金项目2项。发表研究论文160多篇，参编英文书籍4章，获授权的中国发明专利35项。

研究领域:

(1) 设计合成环境响应性生物医用高分子材料(药物载体、基因载体、聚合物前药、水凝胶敷料等)；

(2) 氟碳－碳氢杂化的两亲性聚合物及其应用；

(3) 乳液及细乳液聚合；

(4) 天然高分子的改性。

代表性论文：

1. Liang Yu, Mingzu Zhang, Jinlin He, Xingwei Sun*,Peihong Ni*, “A nanomedicine composed of polymer-ss-DOX and polymer-Ce6 prodrugs with monoclonal antibody targeting effect for anti-tumor chemo-photodynamic synergetic therapy”,Acta Biomaterialia,2024,179,272–283.

2. Haijiao Li, Mingzu Zhang, Jinlin He, Jian Liu, Xingwei Sun*,Peihong Ni*, “CD326 monoclonal antibody modified core cross-linked curcumin-polyphosphoester prodrug for targeted delivery and cancer treatment”Journal of Materials ChemistryB,2023,11, 9467–9477.

3. Wenrui Zhang, Zun Yang, Mingzu Zhang, Jinlin He, Shenzhi Li, Xingwei Sun*,Peihong Ni*, “A hybrid hydrogel constructed using drug loaded mesoporous silica and multiple response copolymer as an intelligent dressing for wound healing of diabetic foot ulcers”,Journal of Materials ChemistryB,2023,11, 4922–4933.

4. Zun Yang，Haijiao Li, Wenrui Zhang, Mingzu Zhang, Jinlin He, Zepeng Yu, Xingwei Sun*,Peihong Ni*,“CD163 monoclonal antibody modified polymer prodrug nanoparticles for targeting tumor-associated macrophages (TAMs) to enhance anti-tumor effect”,Pharmaceutics,2023, 15(4), 1241.

5. Hongrui Tian^‡, Liang Yu^‡, Mingzu Zhang, Jinlin He, Xingwei Sun*,Peihong Ni*, “Dextran-doxorubicin prodrug nanoparticles conjugated with CD147 antibody for targeted drug delivery in hepatoma therapy”,Colloids and Surfaces B: Biointerfaces,2023, 228, 113400. (^‡Equal contribution).

6. Ru Zhou, Mingzu Zhang, Jinlin He, Jian Liu, Xingwei Sun*,Peihong Ni*, “Functional cRGD-conjugated polymer prodrug for targeted drug delivery to liver cancer”,ACSOmega,2022, 7(24),21325-21336.

7. Ya-Kui Huang, Hong-Rui Tian, Ming-Zu Zhang, Jin-Lin He, Jian Liu,Pei-Hong Ni*,“Monoclonal antibody-conjugated polyphosphoester-hyd-DOX prodrug nanoparticles for targeted chemotherapy of liver cancer cells”,Chinese Journal of Polymer Science,2021, 39(11), 1392–1402.

8. Hongrui Tian, Yakui Huang, Jinlin He, Mingzu Zhang,Peihong Ni*,“CD147 monoclonal antibody targeted reduction-responsive campotothecin polyphosphoester nanomedicine for drug delivery in hepatocellular carcinoma cells”,ACS Applied Bio Materials,2021, 4(5), 4422–4431.https://doi.org/10.1021/acsabm.1c00177.

9. Lei Li, Hongrui Tian, Jinlin He, Mingzu Zhang, Zuguang Li,Peihong Ni*,“Fabrication of aminated poly(glycidyl methacrylate)-based polymers for co-delivery of anticancer drugs and the p53 gene”,Journal of Materials Chemistry B,2020, 8(41), 9555–9565.

10. Hongping Li^†, Ru Zhou^†, Jinlin He, Mingzu Zhang, Jian Liu, Xingwei Sun*,Peihong Ni*,“Glucose-sensitive core-cross-linked nanoparticles constructed with polyphosphoester diblock copolymer for controlling insulin delivery”,Bioconjugate Chemistry,2021, 32(9), 2095–2107.(^†Equal contribution).

11. Hongping Li,Jinlin He, Mingzu Zhang, Jian Liu,Peihong Ni*, “Glucose-sensitive polyphosphoester diblock copolymer for insulin delivery system”,ACS Biomaterials Science & Engineering,2020,6(3), 1553–1564.

12. Kun-Ming Che, Ming-Zu Zhang, Jin-Lin He,Pei-Hong Ni*,“Polyphosphoester-modified cellulose nanocrystals for stabilizing Pickering emulsion polymerization of styrene”,Chinese Journal of Polymer Science,2020, 38(9), 921–931.

13. Shuxiang Dong, Yue Sun, Jie Liu, Lei Li, Jinlin He, Mingzu Zhang,Peihong Ni*, “Multifunctional polymeric prodrug with simultaneous conjugating camptothecin and doxorubicin for pH/reduction dual-responsive drug delivery”,ACS Applied Materials & Interfaces,2019, 11(9), 8740–8748.

14. Shuxiang Dong, Jinlin He, Yue Sun, Dian Li, Lei Li, Mingzu Zhang,Peihong Ni*,“Efficient click synthesis of a protonized and reduction-sensitive amphiphilic small-molecule prodrug containing camptothecin and gemcitabine for a drug self-delivery system”,Molecular Pharmaceutics,2019, 16(9), 3770–3779.

15. Dian Li, Yue Song, Jinlin He, Mingzu Zhang,Peihong Ni*, “Polymer-doxorubicin prodrug with biocompatibility, pH response and main chain breakability prepared by catalyst-free click reaction”,ACS Biomaterials Science & Engineering,2019, 5(5), 2307–2315.

16. Yue Song, Dian Li, Jinlin He, Mingzu Zhang,Peihong Ni*, “Facile preparation of pH-responsive PEGylated prodrugs for activated intracellular drug delivery”,Chinese Chemical Letters,2019, 30(12), 2027–2031.

17. Lei Li, Yue Song, Jinlin He, Mingzu Zhang, Jian Liu,Peihong Ni*, “Zwitterionic shielded polymeric prodrug with folate-targeting and pH responsiveness for drug delivery”,Journal of Materials Chemistry B,2019, 7(5), 786–795.

18. Youwen Cao, Jinlin He, Jie Liu, Mingzu Zhang,Peihong Ni*,“Folate-conjugated polyphosphoester with reversible cross-linkage and reduction sensitivity for drug delivery”,ACS Applied Materials & Interfaces,2018,10(9),7811–7820.

19. Jie Liu, Jinlin He, Mingzu Zhang, Guoqiang Xu,Peihong Ni*, “A synergistic polyphosphoester-based co-delivery system of the anticancer drug doxorubicin and the tumor suppressor gene p53 for lung cancer therapy”,Journal of Materials Chemistry B,2018,6(20), 3262–3273.

20. Lei Li Dian Li, Mingzu Zhang, Jinlin He, Jian Liu,Peihong Ni*, “One-pot synthesis of pH/redox responsive polymeric prodrug and fabrication of shell cross-linked prodrug micelles for antitumor drug transportation”,Bioconjugate Chemistry,2018,29(8), 2806–2817.

21. Guoqing Ma, Jie Liu, Jinlin He, Mingzu Zhang,Peihong Ni*, “Dual-responsive polyphosphoester-doxorubicin prodrug containing a diselenide bond: Synthesis, characterization and drug delivery”,ACS Biomaterials Science & Engineering,2018,4(7), 2443–2452.

22. Xueqiong Du, Yue Sun, Mingzu Zhang, Jinlin He,Peihong Ni*, “Polyphosphoester-camptothecin prodrug with reduction-response preparedviamichael addition polymerization and click reaction”,ACS Applied Materials & Interfaces,2017, 9(16), 13939–13949.

23. Yue Sun, Xueqiong Du, Jinlin He, Jian Hu, Mingzu Zhang andPeihong Ni*, “Dual-responsive core-crosslinked polyphosphoester-based nanoparticles for pH/redox-triggered anticancer drug delivery”,Journal of Materials ChemistryB,2017,5(20), 3771–3782.

24. Zi-xu Gu, Jun Cheng, Ming-zu Zhang, Jin-lin He,Pei-hong Ni*, “Effect of Sequence structure on wetting behaviors of fluorinated methacrylate polymers based on perfluorohexylethyl methacrylate and stearyl acrylate”,Chinese Journal of Polymer Science,2017, 35(9), 1061–1072.

25. Zixu Gu, Jun Cheng, Mingzu Zhang, Jinlin He,Peihong Ni*, “Effect of groups atalpha-position and side-chain structure of comonomers on surface energy and surface reorganization of fluorinated methacrylate copolymer”,Polymer,2017, 114, 79–87.

26. Dongling Cao, Jinlin He, Jiaying Xu, Mingzu Zhang, Lin Zhao, Guangxin Duan, Youwen Cao, Ruhong Zhou*,Peihong Ni*, “Polymeric prodrugs conjugated with reduction-sensitive dextran-camptothecin and pH-responsive dextran-doxorubicin: An effective combinatorial drug delivery platform for cancer therapy”,Polymer Chemistry,2016, 7(25), 4198–4212.

27. Sen Li, Jinlin He*, Mingzu Zhang, Hairong Wang,Peihong Ni*, “Multicompartment morphologies self-assembled from fluorinated ABC triblock terpolymers: Effects of flexible and rigid hydrophobic moieties”,Polymer Chemistry,2016,7(9), 1773–1781.

28. Zixu Gu, Mingzu Zhang, Jinlin He,Peihong Ni*, “Surface energy and surface reorganization of perfluorohexylethyl methacrylate/n-alkyl(meth)acrylate copolymers”,Colloid and Surface A: Physicochemical and Engineering Aspects,2016, 502, 159–167.

29. Jian Hu, Mingzu Zhang, Jinlin He andPeihong Ni*, “Injectable hydrogels by inclusion complexation between three-armed star copolymer (mPEG-acetal-PCL-acetal-)₃andalpha-cyclodextrin for pH-triggered drug delivery”,RSC Advances,2016, 6(47), 40858–40868.

30. Kai Ren, Mingzu Zhang, Jinlin He, Yixian Wu,Peihong Ni*, “Polymeric prodrug paclitaxel-poly(lactic acid)-b-polyisobutylene and its application in coatings of drug eluting stent”,ACS Applied Materials & Interfaces,2015,7(21), 11263–11271.

31. Qingqing Zhang, Jinlin He*, Mingzu Zhang,Peihong Ni*, “Polyphosphoester-conjugated camptothecin prodrug with disulfide linkage for potent reduction-triggered drug delivery”,Journal of Materials Chemistry B,2015,3(24), 4922–4932.

32. Jian Hu, Jinlin He*, Mingzu Zhang,Peihong Ni*, “Precise modular synthesis and a structure–property study of acid-cleavable star-block copolymers for pH-triggered drug delivery”,Polymer Chemistry,2015,6, 1553–1566.

33. Jian Hu, Jinlin He, Dongling Cao, Mingzu Zhang,Peihong Ni*, “Core cross-linked polyphosphoester micelles with folate-targeted and acid-cleavable features for pH-triggered drug delivery”,Polymer Chemistry,2015,6, 3205–3216. (Front cover article)

34. Hairong Wang, Jinlin He, Dongling Cao, Mingzu Zhang, Fei Li, Kam Chiu Tam,Peihong Ni*, “Synthesis of an acid-labile polymeric prodrug DOX-acetal-PEG-acetal-DOX with high drug loading content for pH-triggered intracellular drug release”,Polymer Chemistry,2015, 6(26), 4809–4818.

35. Hairong Wang, Jinlin He, Mingzu Zhang, Kam Chiu Tam*,Peihong Ni*, “A new pathway towards polymer modified cellulose nanocrystalsviaa “grafting onto” process for drug delivery”,Polymer Chemistry,2015,6(23), 4206–4209.

36. Fei Li, Jinlin He*, Mingzu Zhang,Peihong Ni*, “A pH-sensitive and biodegradable supramolecular hydrogel constructed from PEGylated polyphosphoester-doxorubicin prodrug and alpha-cyclodextrin”,Polymer Chemistry,2015, 6(28), 5009–5014.

37. 胡健，何金林，张明祖，倪沛红*. “聚磷酸酯的合成及在生物医用材料中的应用”,《高分子通报》,2015,10, 51–65.

38. Jiao Bian, Ying Hao, Jinlin He*, Wenling Zhang, Mingzu Zhang,Peihong Ni*, “Synthesis and characterization of a biodegradable ABC triblock terpolymer as co-delivery carrier of doxorubicin and DNA”,Journal of Polymer Science,Part A:Polymer Chemistry,2014,52(61), 3005–3016.

39. Yang Zhang, Jinlin He*, Dongling Cao, Mingzu Zhang,Peihong Ni*, “Galactosylated reduction and pH dual-responsive triblock terpolymer Gal-PEEP-a-PCL-ss-PDMAEMA a Multifunctional carrier for the targeted and simultaneous delivery of doxorubicin and DNA”,Polymer Chemistry,2014,5(17), 5124–5138.

40. Ying Hao, Jinlin He, Sen Li, Jian Liu, Mingzu Zhang,Peihong Ni*, “Synthesis of an acid-cleavable and fluorescent amphiphilic block copolymer as a combined delivery vector of DNA and doxorubicin”,Journal of Materials Chemistry B,2014,2(27), 4237–4249.

41. Yunfeng Tao, Jinlin He, Mingzu Zhang, Jian Liu,Peihong Ni*, “Galactosylated biodegradablepoly(epsilon-caprolactone-co-phosphoester) random copolymer nanoparticles for potent hepatoma-targeting delivery of doxorubicin”,Polymer Chemistry,2014,5(10), 3443–3452.

42. 肖燕，何金林，陶云锋，张明祖，胡健，倪沛红*.“基于功能化聚磷酸酯嵌段共聚物的微凝胶和水凝胶的制备与表征”,《高分子学报》,2014, 1, 122–130.

43. Hairong Wang, Jinlin He, Mingzu Zhang, Yunfeng Tao, Fei Li, Kam C. Tam,Peihong Ni*,“Biocompatible and acid-cleavable poly(epsilon-caprolactone)-acetal-poly(ethylene glycol)-acetal-poly(epsilon-caprolactone) triblock copolymers: Synthesis, characterization and pH-triggered doxorubicin delivery”,Journal of Materials Chemistry B,2013,1(48), 6596–6607.

44. Guoyi Zhang, Mingzu Zhang, Jinlin He,Peihong Ni*, “Synthesis and characterization of a new multifunctional polymeric prodrug paclitaxel-polyphosphoester-folic acid for targeted drug delivery”,Polymer Chemistry,2013,4(16), 4515–4525.

45. Ying Hao, Jinlin He, Mingzu Zhang, Yunfeng Tao, Jian Liu,Peihong Ni*, “Synthesis and characterization of novel brush copolymers with biodegradable polyphosphoester side chains for gene delivery”,Journal of Polymer Science,Part A:Polymer Chemistry,2013,51(10), 2150–2160.

46. Jiao Bian, Mingzu Zhang, Jinlin He,Peihong Ni*, “Preparation and self-assembly of double hydrophilic poly(ethylethylene phosphate)-block-poly[2-(succinyloxy)ethyl methacrylate] diblock copolymers for drug delivery”,Reactive & Functional Polymers,2013,73(3), 579–587.

47. Huai-chao Wang, Ming-zu Zhang,Pei-hong Ni*, Jin-lin He, Ying Hao, Yi-xian Wu, “Synthesis of pH-responsive amphiphilic diblock copolymers containing polyisobutylene via oxyanion-initiated polymerization and their multiple self-assembly morphologies”,Chinese Journal of Polymer Science,2013,31(2), 218–231.

48. 胡健^‡,何金林^‡,张明祖,倪沛红*, “点击化学在拓扑结构聚合物合成中的应用”,《高分子学报》,2013,3, 300–319. (^‡共同第一作者)

49. Jinlin He, Mingzu Zhang,Peihong Ni*, “Rapidlyin situforming polyphosphoester-based hydrogels for injectable drug delivery carriers”.Soft Matter,2012,8(22), 6033–6038.

50. Ying Hao, Mingzu Zhang, Jinlin He,Peihong Ni*, “Magnetic DNA vector constructed from PDMAEMA polycation and PEGylated brush-type polyanion with cross-linkable shell”,Langmuir,2012,28(15), 6448–6460.

51. Haiyan Shao, Mingzu Zhang, Jinlin He,Peihong Ni*, “Synthesis and characterization of amphiphilic poly(epsilon-caprolactone)-b-polyphosphoester diblock copolymers bearing multifunctional pendant groups”,Polymer,2012,53(14), 2854–2863.

52. Xu Liu,Peihong Ni*, Jinlin He, Mingzu Zhang, “Synthesis and micellization of pH/temperature-responsive double-hydrophilic diblock copolymers polyphosphoester-block-poly[2-(dimethylamino)ethyl methacrylate] prepared via ROP and ATRP”,Macromolecules,2010,43(10), 4771–4781.

53. Zixu Gu, Yuan Yuan, Jinlin He, Mingzu Zhang,Peihong Ni*, “Facile approach for DNA encapsulation in functional polyion complex for triggered intracellular gene delivery: Design, synthesis, and mechanism”,Langmuir,2009,25(9), 5199–5208.

54. Jiang Mao,Peihong Ni*, Yiyong Mai, Deyue Yan, “Multicompartment micelles from hyperbranched star-block copolymers containing polycations and fluoropolymer segment”,Langmuir,2007, 23, 5127-5134.