姓名：何学文

职称：教授，博士生导师

地址：苏州市工业园区仁爱路199号www.优德88.cpm 独墅湖校区701号楼1417室

（邮编215123）

联系方式：Email:xheao@suda.edu.cn

学历及学术经历：

2021年加入www.优德88.cpm （Soochow U）材料与化学化工学部，特聘教授

2019-2021香港科技大学（HKUST）化学与生物工程系，博士后；

2016-2019香港科技大学（HKUST）化学，博士，导师：唐本忠院士；

2012-2016www.优德88.cpm （Soochow U）科研助理，导师：马楠教授；

2009-2012华中科技大学（HUST）生物医学工程，硕士，导师：杨祥良教授；

2005-2009华中科技大学（HUST）生物学，本科；

研究工作：

生命分析化学领域，利用聚集诱导发光分子和量子点等开发新型荧光探针工具和生化分析方法，围绕疾病标志物检测分析、病原微生物识别杀伤、分子影像、疾病诊疗等应用研究展开。近年来在J. Am. Chem. Soc., Angew. Chem., ACS Nano, Nano. Lett., Adv. Funct. Mater., Small, Anal. Chem., Annu. Rev. Anal. Chem.等期刊发表60余篇论文；主持国家自然科学基金青年基金、面上项目、优秀青年基金（海外）等，申请中国/美国发明专利14项，获授权7项。

招生方向：

www.优德88.cpm 马楠/何学文课题组热忱欢迎热爱科研的同学们加入。招生方向包括分析化学、有机化学、生物医学工程、材料专业等。欢迎具有化学、生物学、生物医学工程等背景的同学报考和咨询。常年招收博士后和科研助理，同时欢迎本科生科研实习。有疑问请随时联系xheao@suda.edu.cn

发表的第一作者和通讯作者论文(^#co-first author; *corresponding author)

1. J. Zhang,X. He*, B. Z. Tang*. Aggregation-Induced Emission-Armored Living Bacteriophage-DNA Nanobioconjugates for Targeting, Imaging, and Efficient Elimination of Intracellular Bacterial Infection.ACS Nano2024,18,3199–3213.

2. J. Sun, J. Geng, B. Z. Tang*,X. He*. DNA-Programmed (De)Hybridization of Near-Infrared Photosensitized UCNP-QDs-GNPs Nanoprobes for MicroRNA Imaging and Image-Guided Cancer Therapy.Adv. Funct. Mater.2024,2315299.

3. S. Segawa, X. Ou, T. Shen, T. Ryu, Y. Ishii, H. H. Y. Sung, I. D. Williams, R. T. K. Kwok, K. Onda, K. Miyata,X. He*, X. Liu*, B. Z. Tang*. Matthew Effect: General Design Strategy of Ultra-fluorogenic Nanoprobes with Amplified Dark–Bright States in Aggregates.Aggregate2024,e499.

4. S. Segawa, J. Wu, R. T K Kwok, T. T W Wong*,X. He*,B. Z. Tang*. Co-aggregation as A Simple Strategy for Preparing Fluorogenic Tetrazine Probes with On-Demand Fluorogen Selection.Angew. Chem. Int. Ed.2024,e202313930.

5. S. Segawa,X. He*, B. Z. Tang*. Metal-Free Click and Bioorthogonal Reactions of Aggregation-Induced Emission Probes for Lighting Up Living Systems.Luminescence2024,39,e4619.

6. H. Wang, Q. Li……X. He*…… B. Z. Tang*. Aggregation-Induced Emission (AIE), Life and Health.ACS Nano2023,17(15), 14347-14405.

7. K. W K Lam, J. H C Chau, E. Y Yu, F. Sun, J. W Y Lam, D. Ding, R. T K Kwok*, J. Sun,X. He*, B. Z. Tang*. An Alkaline Phosphatase-Responsive Aggregation-Induced Emission Photosensitizer for Selective Imaging and Photodynamic Therapy of Cancer Cells.ACS Nano2023,17(8), 7145-7156.

8. J. Sun,X. He*.AIE-based drug/gene delivery system: Evolution from fluorescence monitoring alone to augmented therapeutics.Aggregate2022,3,e282.

9. X. He, J. W. Y. Lam, R. T. K. Kwok*, B. Z. Tang*.Real-Time Visualization and Monitoring of Physiological Dynamics by AIEgens.Annu. Rev. Anal. Chem.2021,14,413−435.

10. Q. Yue^#,X. He^#, N. Yan^#, S. Tian, C. Liu, W.-X. Wang*, L. Luo*, B. Z. Tang*. Photodynamic Control of Harmful Algal Blooms by An Ultra-Efficient and Degradable AIEgen-Based Photosensitizer.Chem. Eng. J.2021, 417, 127890.

11. L.-H. Xiong*, S. Huang, Y. Huang, F. Yin, F. Yang, Q. Zhang, J. Cheng*, R. Zhang*,X. He*. Ultrasensitive Visualization of Virus via Explosive Catalysis of an Enzyme Muster Triggering Gold-Nanoaggregate Disassembly.ACS Appl. Mater. Interfaces2020,12,12525-12532.

12. X. He^#, Y. Yang^#,*, Y. Guo, S. Lu, Y. Du, J.-J. Li, X. Zhang, N. L. C. Leung, Z. Zhao, G. Niu, S. Yang, Z. Weng, R. T. K. Kwok, J. W. Y. Lam, G. Xie*, B. Z. Tang*. Phage-Guided Targeting, Discriminative Imaging and Synergistic Killing of Bacteria by AIE Bioconjugates.J. Am. Chem. Soc.2020,142,3959-3969.

13. Z. Wang^#,X. He^#, T.-Y. Yong, Y. Miao, C. Zhang*, B. Z. Tang*. Multicolor Tunable Polymeric Nanoparticle from Tetraphenylethylene-Cage for Temperature Sensing in Living Cells.J. Am. Chem. Soc.2020,142,512-519.

14. X. He^#, C. Peng^#, S. Qiang, L.-H. Xiong, Z. Zhao, Z. Wang, R. T. K. Kwok, J. W. Y. Lam, N. Ma, B. Z. Tang*. Less is More: Silver-AIE Core@Shell Nanoparticles for Multimodality Cancer Imaging and Synergistic Therapy.Biomaterials2020,238,119834.

15. X. He^#, L.-H. Xiong^#, Y. Huang, Z. Zhao, Z. Wang, J. W. Y. Lam, R. T. K. Kwok*, B. Z. Tang*. AIE-Based Energy Transfer Systems for Biosensing, Imaging, and Therapeutics.TrAC-Trend.Anal. Chem.2020,122,115743.

16. X. He^#, L.-H. Xiong^#, Z. Zhao, Z. Wang, L. Luo, J. W. Y. Lam, R. T. K. Kwok*, B. Z. Tang*.AIE-Based Theranostic Systems for Detection and Killing of Pathogens.Theranostics2019,9,3223–3248.

17. X. He^#, F. Yin^#, D. Wang, L.-H. Xiong, R. T. K. Kwok, P. F. Gao, Z. Zhao, J. W. Y. Lam, K.-T. Yong, Z. Li*, B. Z. Tang*.AIE Featured Inorganic–Organic Core@Shell Nanoparticles for High-Efficiency siRNA Delivery and Real-Time Monitoring.Nano Lett.2019,19,2272–2279.

18. N. Yan^#,X. He^#, B. Z. Tang*, W.-X. Wang*. Differentiating Silver Nanoparticles and Ions in Medaka Larvae by Coupling Two Aggregation-Induced Emission Fluorophores.Environ. Sci. Technol.2019,53,5895–5905.

19. X. He, Z. Zhao, L.-H. Xiong, P. F. Gao, C. Peng, R. S. Li, Y. Xiong, Z. Li, H. H.-Y. Sung, I. D.Williams, R. T. K. Kwok, J. W. Y. Lam, C. Z. Huang, N. Ma, B. Z. Tang*.Redox-Active AIEgen-Derived Plasmonic and Fluorescent Core@Shell Nanoparticles for Multimodality Bioimaging.J. Am. Chem. Soc.2018,140,6904–6911.

20. L.-H. Xiong^#,X. He^#, Z. Zhao^#, R. T. K. Kwok, Y. Xiong, P. F. Gao, F. Yang, Y. Huang, H. H.-Y. Sung, I. D. Williams, J. W. Y. Lam, J. Cheng*, R. Zhang*, B. Z. Tang*.Ultrasensitive Virion Immunoassay Platform with Dual-Modality Based on a Multifunctional Aggregation-Induced Emission Luminogen.ACS Nano2018,12,9549–9557.

21. L.-H. Xiong^#,X. He^#, J. Xia, H. Ma, F. Yang, Q. Zhang, D. Huang, L. Chen, C. Wu, X. Zhang, Z. Zhao, C. Wan*, R. Zhang*, J. Cheng*.Highly Sensitive Naked-Eye Assay for Enterovirus 71 Detection Based on Catalytic Nanoparticle Aggregation and Immunomagnetic Amplification.ACS Appl. Mater. Interfaces2017,9,14691−14699.

22. X. He,T. Zeng, Z. Li, G. Wang, N. Ma*. Catalytic Molecular Imaging of MicroRNA in Living Cells via DNA-Programmed Nanoparticles Disassembly.Angew. Chem. Int. Ed.2016,55,3073−3076.

23. X. He,Z.Li, M.Chen, N. Ma*. DNA-Programmed Dynamic Assembly of Quantum Dots for Molecular Computation.Angew. Chem. Int. Ed.2014,53,14447−14450.

24. X. He, N. Ma*.A General Strategy for Label-Free Sensitive DNA Detection Based on Quantum Dot Doping.Anal. Chem.2014,86,3676−3681.

25. X. He, N. Ma*.An Overview of Recent Advance of Quantum Dots for BiomedicalApplications.Colloids Surf. B: Biointerfaces2014,124,118−131.

26. X. He, L. Gao, N. Ma*. One-Step Instant Synthesis of Protein-Conjugated Quantum Dots at Room Temperature.Sci. Rep.2013,3,2825.

27. X. He, N. Ma*. Biomimetic Synthesis of Fluorogenic Quantum Dots for Ultrasensitive Label-Free Detection of Protease Activities.Small2013,9,2527−2531.